Retinal vein occlusion in COVID-19: A novel entity

Sheth, Jay; Narayanan, Raja; Goyal, Jay; Goyal, Vinod Kumar

doi:10.4103/ijo.ijo_2380_20

Cited by 132 publications

(114 citation statements)

References 9 publications

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“…Management is with anti-vascular endothelial growth factor (anti-VEGF) in the established phase. [ 35 36 37 38 ] In patients with systemic comorbidities with severe COVID-19 infection, early anticoagulant prophylaxis should be considered. Central retinal artery occlusion (CRAO) Sudden onset of painless vision loss can herald the occlusion of central retinal artery with grave visual prognosis.…”

Section: Posterior Segment Manifestations Of Covid-19mentioning

confidence: 99%

COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19

Sen

Honavar

Sharma

et al. 2021

Indian J Ophthalmol

232

112

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The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had health implications of unprecedented magnitude. The infection can range from asymptomatic, mild to life threatening respiratory distress. It can affect almost every organ of the body. Ophthalmologists world over are reporting various manifestations of the infection in the eye. This review was undertaken to help ophthalmologists recognize the possible manifestations and the stage of the viral disease when they commonly appear. Literature search was performed for the publications on ophthalmic manifestations of coronavirus disease-19 (COVID-19) between January 1, 2020 and January 31, 2021. 46 case reports, 8 case series, 11 cross sectional/cohort observational studies, 5 prospective interventional studies, 3 animal models/autopsy studies and 6 reviews/meta-analysis were included. Conjunctivitis is the most common manifestation and can develop at any stage of the disease. Direct effect due to virus, immune mediated tissue damage, activation of the coagulation cascade and prothrombotic state induced by the viral infection, the associated comorbidities and drugs used in the management are responsible for the findings in the eye. The viral ribonucleic acid (RNA) has been isolated from ocular tissues but the role of eye as a route for infection is yet to be substantiated. Ophthalmic manifestations may be the presenting feature of COVID-19 infection or they may develop several weeks after recovery. Ophthalmologists should be aware of the possible associations of ocular diseases with SARS-CoV-2 in order to ask relevant history, look for specific signs, advise appropriate tests and thereby mitigate the spread of infection as well as diagnose and initiate early treatment for life and vision threatening complications.

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Section: Posterior Segment Manifestations Of Covid-19mentioning

confidence: 99%

COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19

Sen

Honavar

Sharma

et al. 2021

Indian J Ophthalmol

232

112

View full text Add to dashboard Cite

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“…Retinal vein vasculitic occlusion was found in a 52-year-old man 10 days after COVID-19 symptoms appeared, but his visual acuity improved after treatment with corticosteroids and intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection (161). Another 54-year-old woman developed bilateral anterior uveitis 14 days after COVID-19-associated MIS-A but responded to topical corticosteroids (61).…”

Section: Ocular Manifestationsmentioning

confidence: 99%

Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review

2021

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Background: Numerous cases of the coronavirus disease 2019 (COVID-19) with autoimmune and rheumatic manifestations have been reported. Despite the available reviews that summarized its autoimmune/rheumatic manifestations, a systematic approach is still lacking. Therefore, we conducted a comprehensive systematic review in order to give an overview upon these rare but clinically significant manifestations.Methods: We performed a literature search of PubMed and EMBASE as of October 9, 2020. All articles relevant to either systemic or organ-specific autoimmune and rheumatic manifestations potentially associated with COVID-19 were collected. The reviewed literature were limited to adults ≥18 years.Results: Although most of the existing evidence was based on case reports or case series without a long-term follow-up, a variety of autoimmune/rheumatic manifestations were associated with COVID-19. The manifestations that have a consistent association with COVID-19 include autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. Such association is conflicting as regards to antiphospholipid syndrome, hemophagocytic lymphohistiocytosis, and myasthenia gravis.Conclusion: Our systematic review indicated the potential of the COVID-19 virus to trigger a myriad of autoimmune and rheumatic manifestations, which should be considered amid global efforts to combat COVID-19.

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“…Although a similar event was diagnosed in our patient, no proven active SARS-COV-2 infection was established at the moment of the event. Interestingly, other case reports also described the end of COVID-19 symptoms 10-14 days prior to a retinal vein occlusion [16,17]. In addition, a case report of a COVID-19 related renal infarct by Wu, et al suggests a hypercoagulative state that may persist long after the resolution of COVID-19 [18].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Presentation of Pyelonephritis: Is it COVID-19 Related?

Hof

Pellikaan

Soonawala

et al. 2021

Preprint

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IntroductionIn severe cases of COVID-19, late complications such as coagulopathy and organ injury are increasingly described. In milder cases of the disease, the exact time frame and causal path of late onset complications has not yet been determined. Although direct and indirect renal injury by SARS-CoV-2 has been confirmed, hemorrhagic renal infection or coagulative problems in the urinary tract have not yet been described.Case PresentationThis case report describes a 35-year-old female without relevant medical history who, five days after having recovered from an infection with SARS-CoV-2, had an unusual course of acute pyelonephritis of the right kidney and persistent fever under targeted antibiotic treatment. A hemorrhagic ureteral obstruction and severe swollen renal parenchyma preceded the onset of fever and was related to the developing pyelonephritis. Sudden thrombotic vascular occlusion in the right eye appeared during admission. Symmetrical paresthesia in de limbs in combination of severe lower back pain and gastro-intestinal manifestation was documented and not been explained despite of intensive investigation.ConclusionWe present the unusual combination of culture confirmed bacterial hemorrhagic pyelonephritis with a blood clot in the proximal right ureter, complicated by a retinal venous thrombosis, in a patient who had recovered from SARS-CoV-2-infection five days before presentation. The case is suspect of a COVID-19 related etiology.

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Retinal vein occlusion in COVID-19: A novel entity

Cited by 132 publications

References 9 publications

COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19

COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19

Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review

An Unusual Presentation of Pyelonephritis: Is it COVID-19 Related?

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