Retinal vein occlusion following intravenous immunoglobulin treatment

Nawasiwatte, B M T P; Somaratne, S C; Fernando, Amitha; Gunaratne, Padma

doi:10.4038/cmj.v57i4.5087

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Although considered safe, even in high dose, IVIG can cause thromboembolic events such as stroke, myocardial infarctus, deep vein thrombosis and/or pulmonary thrombosis, peripheral arterial occlusion, spinal arterial occlusion and retinal infarct, superficial vein thrombosis, central retinal vein thrombosis and transvers sinus vein thrombosis (2-6). To date, as far as we know, there are 5 cases in the literature that CRVO is developed with IVIG treatment and none of these cases have dermatological disease (2)(3)(4)(5)(6). Table 1 shows the summary of these cases.…”

Section: Discussionmentioning

confidence: 99%

Central Retinal Vein Occlusion Following Intravenous Immunoglobulin Treatment in a Patient with Pemphigus Vulgaris

Gönül¹,

Atacan²

2017

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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A 68-year-old male has been treated with prednisolone and intravenous immunoglobulin (IVIG) therapies with the diagnosis of pemphigus vulgaris. When he applied to receive the fifth session of IVIG therapy, he complained about visual loss. On the ophthalmologic examination, left central retinal vein occlusion (CRVO) was determined. There was no other detected underlying cause for CRVO and it was thought that central retinal vein thrombosis might be due to IVIG therapy. IVIG treatment is generally accepted reliable for pemphigus vulgaris. However, it can rarely cause serious side effects like thrombosis. In literature, there are a few cases of central retinal vein occlusion due to IVIG therapy and none of these have dermatological disease as their etiology.

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