Retinal vein cannulation with prolonged infusion of tissue plasminogen activator (t-PA) for the treatment of experimental retinal vein occlusion in dogs

Tameesh, Mohamed K; Lakhanpal, Rohit R.; Fujii, Gildo Y.; Javaheri, Michael; Shelley, Terry H; D’Anna, Salvatore A.; Barnes, A.; Margalit, Eyal; Farah, Michel Eid; Juan, Eugene de; Humayun, Mark S.

doi:10.1016/j.ajo.2004.06.083

Cited by 32 publications

(36 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…provided histological data revealing only minimal vascular damage caused by vessel cannulation [4]. Injection of tissue plasminogen activator in a retinal vessel for the treatment of central retinal vein occlusion has been studied in dogs [5] as well as in a few clinical studies in humans [7,8].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In vivo redirection of retinal blood flow into borosilicate micro-cannulas in rabbits

Christoforidis

Warden

DeMattia

et al. 2006

Graefe's Arch Clin Exp Ophthalmo

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…In vivo studies thus far have largely focused on vessel cannulation and injection of various vasoactive substances [1,2,4]. This work has been applied clinically to the treatment for central retinal vein occlusion through injection of tissue plasminogen activator [5,7,8].…”

Section: Introductionmentioning

confidence: 99%

In vivo redirection of retinal blood flow into borosilicate micro-cannulas in rabbits

Christoforidis

Warden

DeMattia

et al. 2006

Graefe's Arch Clin Exp Ophthalmo

View full text Add to dashboard Cite

show abstract

“…However, the eye of mice or rats is too small to permit investigative surgical procedures. The structure of the retina in pigs [12,15] , cats [8] or dogs [4] is similar to that in humans except that it does not have a macular region. The retinal blood supply in rhesus monkeys [16,17] is similar to that in human; however, the sources of these animals are limited, and they are difficult to breed and manage.…”

Section: Discussionmentioning

confidence: 99%

“…The pathological features of BRVO can be more accurately reproduced by a photodynamic method to induce thrombosis in retinal vessels [4][5][6][7][8][9][10][11][12][13][14] than by using other methods such as laser coagulation [15][16][17] , electrocoagulation of the retinal vein via the vitreous body [18] , intravenous thrombin instillation [19][20][21] and endothelin-I injection into the posterior vitreous body [22,23] . In the photodynamic method, a photosensitizing agent, namely, rose Bengal, is injected intravenously.…”

Section: Introductionmentioning

confidence: 99%

Induction of Branch Retinal Vein Occlusion by Photodynamic Therapy with Rose Bengal in a Rabbit Model

Zhou¹,

Song²,

Zhao³

et al. 2012

Advances in Ophthalmology

View full text Add to dashboard Cite

“…Recent research of this subject has mostly focused on the re-establishment of retinal venous outflow, including intravascular injection of vasoactive substances, 2 arteriovenous crossing sheathotomy, [3][4][5][6] and chorioretinal anastomosis. [7][8][9] Bypassing the occluded retinal vessel segment with artificial graft, similar to clinical cure for myocardial ischemia using coronary artery bypass grafting, has been demonstrated feasible in an animal eyecup model.…”

Section: Introductionmentioning

confidence: 99%

Feasibility study on retinal vascular bypass surgery in isolated arterially perfused caprine eye model

Chen

Zhang

et al. 2011

Eye

View full text Add to dashboard Cite

Purpose To investigate the feasibility of bypassing occluded segments of retinal venous main vessels in isolated, arterially perfused caprine eyes via the closed-sky vitrectomy approach using keratoprosthesis. Methods Isolated caprine eyes were used in this study. For each eye, the retinal vessel was perfused by Krebs solution via ophthalmic artery, and pars plana vitrectomy was performed using temporary keratoprosthesis. All retinal micro-vascular maneuvers were performed in a closed-sky eyeball. The main retinal vein was blocked by endodiathermy at the site of the vessel's first branching. Two openings, several millimeters apart, were created by vascular punctures in both the main vein and its branch vein wall straddling the induced occluded segment. Catheterization was achieved using a flexible polyimide tube, with each end inserted into the vessel wall opening. A sealed connection between the vessel and the tube was obtained by endodiathermy. Bypass of the occluded retinal vein segment was thus achieved, and the patency of this vascular bypass was confirmed by intravascular staining. Results Puncturing, catheterization, and endodiathermy were viable by closed-sky approach using keratoprosthesis. Bypassing of the occluded retinal main vein segment was accomplished with the combination of these maneuvers. Good results were obtained in 23 of 38 (60%) caprine eyes. Conclusions This study demonstrated that bypassing the occluded segment of retinal main vein can be successfully performed in a closedsky eyeball model of isolated, arterially perfused caprine eye. This early work indicated that the more advanced retinal vascular bypass surgery in in vivo eye may be feasible in the future.

show abstract

Retinal vein cannulation with prolonged infusion of tissue plasminogen activator (t-PA) for the treatment of experimental retinal vein occlusion in dogs

Cited by 32 publications

References 23 publications

In vivo redirection of retinal blood flow into borosilicate micro-cannulas in rabbits

In vivo redirection of retinal blood flow into borosilicate micro-cannulas in rabbits

Induction of Branch Retinal Vein Occlusion by Photodynamic Therapy with Rose Bengal in a Rabbit Model

Feasibility study on retinal vascular bypass surgery in isolated arterially perfused caprine eye model

Contact Info

Product

Resources

About