Retinal vascular patterns in domestic animals

Schaepdrijver, Luc De; Simoens, Paul; Lauwers, Henri; Geest, J. P. De

doi:10.1016/s0034-5288(18)31228-1

Cited by 96 publications

(92 citation statements)

References 10 publications

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“…Retinal images of 4 cloned sheep from the same parent line were evaluated to confirm the uniqueness of the retinal vessel patterns in genetically identical animals. This would be confirming the uniqueness of animal retinal vascular pattern suggested earlier in the 1980s also by De Schaepdrijver et al (1989). In general, retinal vessel tree his is a unique pattern in each individual and it is almost impossible to forge that pattern in a false individual.…”

Section: Related Worksupporting

confidence: 85%

Retinal vessel tree as biometric pattern

Ortega¹,

Penedo²

2011

Biometrics

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Section: Related Worksupporting

confidence: 85%

Retinal vessel tree as biometric pattern

Ortega¹,

Penedo²

2011

Biometrics

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“…The rabbit retina is merangiotic; that is, retinal blood vessels are confined to the myelinated streak, and the major part of the retina has been reported to be dependent on choroidal blood supply. 21 The current experiment, as well as our previously published studies on full-thickness neuroretinal transplants, suggests that rabbit photoreceptors are more vulnerable to retinal detachment than inner retinal cells. 17,20 The reduction of the ONL seen already after 7 days in combination with massive TUNEL labeling and almost complete ablation of this layer after 28 days suggests that the PGS membrane effectively blocks the diffusion of nutrients from the choroid leading to apoptotic cell death of photoreceptors.…”

Section: Discussionsupporting

confidence: 68%

Selective Removal of Photoreceptor CellsIn VivoUsing the Biodegradable Elastomer Poly(Glycerol Sebacate)

Ghosh

Neeley

Arnér

et al. 2011

Tissue Engineering Part A

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Retinal transplantation experiments have advanced considerably during recent years, but remaining diseased photoreceptor cells in the host retina physically obstruct the development of graft-host neuronal contacts that are required for vision. We here report selective removal of photoreceptors using the biodegradable elastomer poly(glycerol sebacate) (PGS). A 1Â3 mm PGS membrane was implanted in the subretinal space of normal rabbit eyes, and morphologic specimens were examined with hematoxylin and eosin staining and a panel of immunohistochemical markers. Seven days postoperatively, a patent separation of the neuroretina and retinal pigment epithelium was found as well as loss of several rows of photoreceptors in combination with massive terminal transferase-mediated dUTP nick-end labeling (TUNEL) staining for apoptosis in the outer nuclear layer. After 28 days, the neuroretina was reattached, the PGS membrane had degraded, and photoreceptors were absent in the implantation area. Activated Mü ller cells were found in the entire retina in 7-day specimens, and in the implantation area after 28 days. AII amacrine and rod bipolar cell morphology was not affected, except for disrupted dendritic branching, which was present in rod bipolar cells in 28-day specimens. We conclude that retinal detachment induced by the biodegradable PGS membrane creates a permissive environment in which graft-host neuronal connections may be facilitated in future retinal transplantation experiments.

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“…In the present study, inner retinal layers of the grafts appeared to be more preserved compared with long-term fetal rabbit grafts. This difference may be explained by the completely vascularized nature of the porcine retina in contrast to the merangiotic nature of the rabbit retina [7]. Whether it is possible to induce sprouting in a completely vascularized retina without sacrificing the intricate organization of retinal neurons is indeed a great future challenge for retinal transplantation research.…”

Section: Graft-host Integrationmentioning

confidence: 99%

Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa

Ghosh

Engelsberg

English

et al. 2006

Graefe's Arch Clin Exp Ophthalmol

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Purpose: To explore neuroretinal transplantation in a large-animal model of severe retinitis pigmentosa, and to establish graft development, long-term survival, graft-host integration and effects on the host retina.Methods: Rhodopsin transgenic pigs, aged 6 months, in 1 eye received a fetal full-thickness neuroretinal sheet in the subretinal space by means of vitrectomy and retinotomy. Six months postoperatively, eyes were studied in the light microscope, and with immunohistochemical markers. Full-field ERG was performed at 4 and 6 months.Results: Laminated grafts with well organized photoreceptors, rod bipolar cells and Müller cells were found in 5 out of 6 eyes. Neuronal connections between graft and host retina were not seen. In the 5 eyes containing a graft, the number of surviving rods in the host retina was significantly higher compared with unoperated eyes. The ERG did not reveal any significant difference in b-wave amplitude between operated and control eyes, but the cone derived response in operated eyes increased significantly from 4 to 6 months while the rod response in control eyes decreased significantly. Conclusions:Fetal full-thickness neuroretina can be transplanted safely to an eye with a severe retinal degeneration. In their major part, the transplants develop a normal laminated morphology and survive for at least 6 months. Graft and host retinal neurons do not form connections. Retinal function in the host is reduced initially by the surgical trauma but the presence of a well laminated graft counteracts this effect and rescues rods from degeneration.

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Retinal vascular patterns in domestic animals

Cited by 96 publications

References 10 publications

Retinal vessel tree as biometric pattern

Retinal vessel tree as biometric pattern

Selective Removal of Photoreceptor CellsIn VivoUsing the Biodegradable Elastomer Poly(Glycerol Sebacate)

Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa

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