Retinal Vascular Findings in Sickle Cell Retinopathy
Abstract:Sickle cell disease (SCD) is a common inherited blood disease that develops due to hemoglobin (Hb) dot mutation that reduces the oxygen-carrying ability of erythrocytes. In hypoxia, this mutated abnormal Hb causes "sickling" of erythrocytes, and subsequent episodes of hypoxia, acidosis, inflammation, vaso-occlusive crises, and hemolysis cause progressive damage to many organs, including the brain, kidneys, lungs, bones, heart, and eyes. Systemic and ocular findings vary in SCD. Sickle Cell C Disease and Sickle… Show more
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