Retinal vascular density evaluated by optical coherence tomography angiography in macular telangiectasia type 2

Doğan, Berna; Erol, Muhammet Kazım; Akıdan, Melih; Süren, Elçin; Akar, Yusuf

doi:10.1007/s10792-018-01060-x

Cited by 14 publications

(23 citation statements)

References 34 publications

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“…This adds greater detail to prior work demonstrating a decreased overall parafoveal vascular density in MacTel. 4,8,10 Furthermore, we found that the increase in A/V capillary ratio occurs before this decrease in overall parafoveal VD, which was only significantly decreased among our advanced MacTel subjects with OCTA evidence of subretinal neovascularization. As shown in Figure 5, the A/V capillary ratio is elevated very early in disease, in subjects without other OCT metrics of disease progression, such as ellipsoid loss, pigment, or hyperreflective foci.…”

Section: Discussionmentioning

confidence: 51%

“…3 Later vascular anomalies include enlargement of the foveal avascular zone, decrement in parafoveal vascular density (VD), and ultimately neovascularization. [3][4][5] Yannuzzi et al classified MacTel into either nonproliferative or proliferative stages based on evidence of subretinal neovascularization on clinical examination, fluorescein angiography (FA), and optical coherence tomography (OCT). 6 Proliferative MacTel may be further subclassified by the depth of neovascularization whether in the outer retina 5 or subretinal.…”

Section: Introductionmentioning

confidence: 99%

“…Parafoveal VD is a quantitative metric for retinal capillary loss and can be assessed using optical coherence tomography angiography (OCTA). 4,8,9 Patients with MacTel have been shown to have a lower parafoveal VD in the superficial capillary plexus (SCP) and deep capillary plexuses (DCP) when compared with healthy controls. 4,8,10 Topographical changes in parafoveal VD have also been documented in MacTel, with lowest parafoveal VD found in the temporal parafovea.…”

Section: Introductionmentioning

confidence: 99%

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Perivenular Capillary Loss: An Early, Quantifiable Change in Macular Telangiectasia Type 2

Micevych

Soetikno

Fawzi

2020

Trans. Vis. Sci. Tech.

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To evaluate differences in parafoveal vascular density surrounding arterioles and venules in type 2 macular telangiectasia (MacTel). Methods: Thirty-seven eyes (20 subjects) diagnosed with MacTel and 16 healthy eyes (10 subjects) were imaged with optical coherence tomography angiography between March 2016 and June 2019 in this single-center, observational, cross-sectional study. Arterioles and venules were manually identified, and perivascular density was generated using a custom MATLAB code. The primary outcome measure was the ratio of periarteriolar to perivenular vascular density (arteriovenous [A/V] capillary ratio) in the superficial and deep capillary plexuses across MacTel stages. The main secondary outcome measures were overall parafoveal vascular density (VD), periarteriolar VD, and perivenular VD. Results: In the superficial capillary plexus (SCP), the A/V capillary ratio was significantly higher in MacTel subjects than controls (0.914 vs. 0.892; P = 0.0044). The greatest differences occurred between controls and nonproliferative MacTel subjects without optical coherence tomography evidence of disease (P = 0.0055). A/V capillary ratios progressed in a nonlinear fashion with MacTel severity, increasing from nonproliferative disease (0.912) to intraretinal proliferative disease (0.931), then decreasing in subretinal proliferative disease (0.905). Parafoveal VD in the SCP was lower in MacTel subjects than controls only in subretinal proliferative disease (P = 0.0130). Conclusions: The A/V capillary ratio of the SCP is a quantifiable metric of vascular pathology in MacTel that occurs earlier than decline in parafoveal VD. Elevated A/V capillary ratios in MacTel are consistent with an early, disproportionately perivenular disruption in the SCP. Translational Relevance: Findings inform MacTel pathogenesis through revealing early perivenular capillary loss and offer a new quantitative metric for earliest stage MacTel.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Perivenular Capillary Loss: An Early, Quantifiable Change in Macular Telangiectasia Type 2

Micevych

Soetikno

Fawzi

2020

Trans. Vis. Sci. Tech.

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“…OCTA has shown an increase in the intervascular spaces with progressive capillary rarefaction and abnormal capillary anastomosis and a vascular invasion in the normally avascular outer retina [9], [10]. Early changes in the retinal microvasculature begin temporal to the fovea in the DCP and then extend into the SCP [7], [8], [9], [10], [11]. OCTA imaging not only helps to facilitate the early diagnosis of MacTel2 but also provides a better understanding of disease progression and treatment efficacy [12].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of 1-year follow-up results of macular telangiectasia type 2 cases by optical coherence tomography angiography

Demir

Güven

Karataş

et al. 2019

GMS Ophthalmology Cases; 9:Doc29

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“…The widespread availability of this technology has resulted in an enormous growth in the study of retinal vasculature in various systemic and ocular diseases. 1 Of particular interest is the foveal avascular zone (FAZ) and its surrounding microvasculature, which have been shown to be affected by physiologic sex-associated hormonal changes 2 – 4 and diseases, such as diabetic retinopathy, 5 macular degeneration, 6 hypertension, 7 sickle cell disease, 8 macular telangiectasia, 9 retinopathy of prematurity, 10 and albinism. 11 Central to using OCT-A imagery to diagnose and monitor conditions like these is the ability to extract quantitative metrics describing the retinal vasculature.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics

Kraker

Omoba

Cava

et al. 2020

Trans. Vis. Sci. Tech.

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The purpose of this study was to investigate the effect of device and scan size on quantitative optical coherence tomography angiography (OCT-A) metrics. Methods: The 3 × 3 mm scans from Optovue AngioVue and Zeiss AngioPlex systems were included for 18 eyes of 18 subjects without ocular pathology. The foveal avascular zone (FAZ) was segmented manually by two observers, from which estimates of FAZ area (using both the nominal image scale and the axial length corrected image scale) and acircularity were derived. Three scan sizes (3 mm, 6 mm HD, and 8 mm) from the AngioVue system were included for 15 eyes of 15 subjects without ocular pathology. For each subject, larger image sizes were resized to the same resolution as 3 × 3 mm scans, aligned, then cropped to a common area. FAZ area, FAZ acircularity, average and total parafoveal intercapillary area, vessel density, and vessel end points were computed. Results: Between the devices used here, there were no significant differences in FAZ acircularity (P = 0.88) or FAZ area using scaled (P = 0.11) or unscaled images (P = 0.069). Although there was no significant difference in FAZ area across scan sizes (P = 0.30), vessel morphometry metrics were all significantly influenced by scan size. Conclusions: The scan devices and sizes used here do not affect FAZ area measures derived from manual segmentations. In contrast, vessel morphometry metrics are affected by scan size. As individual differences in axial length induce differences in absolute scan size, extreme care should be taken when interpreting metrics of vessel morphometry, both between and within OCT-A devices. Translational Relevance: A better characterization of the confounds surrounding OCT-A retinal vasculature metrics can lead to improved application of these metrics as biomarkers for retinal and systemic diseases.

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Retinal vascular density evaluated by optical coherence tomography angiography in macular telangiectasia type 2

Cited by 14 publications

References 34 publications

Perivenular Capillary Loss: An Early, Quantifiable Change in Macular Telangiectasia Type 2

Perivenular Capillary Loss: An Early, Quantifiable Change in Macular Telangiectasia Type 2

Evaluation of 1-year follow-up results of macular telangiectasia type 2 cases by optical coherence tomography angiography

Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics

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