Retinal toxicities of systemic anticancer drugs

Arora, Supriya; Surakiatchanukul, Thamolwan; Arora, Tarun; Errera, Marie Hélène; Agrawal, Hitesh; Lupidi, Marco; Chhablani, Jay

doi:10.1016/j.survophthal.2021.05.007

Cited by 18 publications

(15 citation statements)

References 450 publications

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“…Tamoxifen is a selective estrogen receptor modulator (SERM) that is commonly used in the treatment of estrogen receptor positive (ER+) breast cancer. Tamoxifen is associated with retinopathy characterized by refractile superficial crystalline deposits in the inner retina and punctate gray lesions in the retinal pigment epithelium and outer retina [ 89 ]. The parafoveal hyperreflective deposits can be also seen on OCT in an affected patient [ 90 ].…”

Section: Tamoxifenmentioning

confidence: 99%

Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity

et al. 2022

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It is important for clinicians to consider exposure to toxic substances and nutritional deficiencies when diagnosing and managing cases of vision loss. In these cases, physiologic damage can alter the function of key components of the visual pathway before morphologic changes can be detected by traditional imaging methods. Electrophysiologic tests can aid in the early detection of such functional changes to visual pathway components, including the retina or optic nerve. This review provides an overview of various electrophysiologic techniques, including multifocal electroretinogram (mfERG), full-field ERG (ffERG), electrooculogram (EOG), pattern electroretinogram (PERG), and visual evoked potential (VEP) in monitoring the retinal and optic nerve toxicities of alcohol, amiodarone, cefuroxime, cisplatin, deferoxamine, digoxin, ethambutol, hydroxychloroquine, isotretinoin, ocular siderosis, pentosane, PDE5 inhibitors, phenothiazines (chlorpromazine and thioridazine), quinine, tamoxifen, topiramate, vigabatrin, and vitamin A deficiency.

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Section: Tamoxifenmentioning

confidence: 99%

Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity

et al. 2022

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“…Verschiedene Medikamente sind mit kristallinen Ablagerungen in der Netzhaut assoziiert. Aufgrund der seit vielen Jahren reduzierten Dosierung von Tamoxifen und Toramifen (Nachbehandlung hormonsensitiver Mammakarzinome) sind diese extrem selten [16]. Bei gleicher Indikation wurden bei Anastrozol in Einzelfällen kristalline Ablagerungen beschrieben.…”

Section: Kristalline Retinopathieunclassified

“…Taxane (Zytostatika bei verschiedener Malignome) bewirken oft eine Verdickung der zentralen Netzhaut und selten ein bilaterales ZMÖ [16]. In der OCT ist das ZMÖ besser erkennbar als in der FAG.…”

Section: Zystoides Makulaödemunclassified

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Exogen bedingte Retinopathien

Kellner¹,

Kellner²,

Weinitz³

et al. 2022

Augenheilkunde up2date

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ZusammenfassungExogen bedingte Retinopathien werden am häufigsten durch externe Stimulanzien, seltener durch unerwünschte Arzneimittelwirkungen systemisch oder intravitreal eingesetzter Medikamente und noch seltener durch Impfungen oder die Einwirkung von Lichtstrahlung verursacht. Die Kenntnis exogener Ursachen und ihre mögliche Symptomatik ist zur Prophylaxe oder zur Früherkennung schädigender Wirkungen und zur adäquaten Beratung der Patienten wichtig.

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“…[7,8] Moreover, side effects, including limited bioavailability, toxicity, nonspecificity, and fast clearance are also one of the major obstacles to successful cancer therapy. [9,10] To circumvent the above problems, novel anticancer agents are needed urgently.…”

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confidence: 99%

The anticancer activity of carbazole alkaloids

Song

Liú

Huo

et al. 2021

Archiv der Pharmazie

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Chemotherapy is the first choice for the majority of cancers, but severe side effects and drug resistance restrict the actual clinical efficacy. Carbazole alkaloids, mainly from the Rutaceae family, possess favorable donor ability, good planarity, rich photophysical properties, and excellent biocompatibility. Carbazole alkaloids could not only intercalate in DNA but could also inhibit telomerase and topoisomerase and regulate protein phosphorylation. Hence, carbazole alkaloids are useful in providing lead hits/candidates for the development of novel anticancer agents. This review summarizes the research progress made regarding the anticancer properties of carbazole alkaloids, covering articles published from January 2010 to June 2021.

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Retinal toxicities of systemic anticancer drugs

Cited by 18 publications

References 450 publications

Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity

Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity

Exogen bedingte Retinopathien

The anticancer activity of carbazole alkaloids

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