Retinal Surface en Face Optical Coherence Tomography

Rispoli, Marco; Rouic, Jean-François Le; Lesnoni, Guido; Colecchio, Livio; Catalano, Susanna; Lumbroso, Bruno

doi:10.1097/iae.0b013e3182562076

Cited by 36 publications

(8 citation statements)

References 20 publications

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“…New software updates to SD OCT systems now enable en face imaging of the retinal surface. Rispoli et al 33 examined 20 consecutive patients with idiopathic ERMs using en face OCT imaging, and identified areas of small craters and pits adjacent to the plaque membrane. They hypothesise that membrane contraction causes localised tearing and folding of the ILM, exposing the bare retinal nerve fibre layer underneath.…”

Section: Future Directionsmentioning

confidence: 99%

Optical coherence tomography in the preoperative and postoperative management of macular hole and epiretinal membrane

Goldberg,

Waheed,

Duker

2014

Br J Ophthalmol

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Optical coherence tomography (OCT) imaging plays an essential role in the diagnosis and treatment of macular diseases, including those of the vitreomacular interface. OCT enables accurate diagnosis and differentiation of full thickness macular hole, lamellar macular hole and epiretinal membrane, with or without the presence of vitreomacular adhesion. This information enables earlier diagnosis and treatment when necessary, and can guide the choice of therapy. OCT is useful to facilitate discussions with patients and manage the visual expectations. Postoperatively, OCT can be helpful to optimise patient comfort and visual outcomes. As the technology continues to improve, OCT will become increasingly critical for all aspects of care for patients with macular hole and epiretinal membrane.

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Section: Future Directionsmentioning

confidence: 99%

Optical coherence tomography in the preoperative and postoperative management of macular hole and epiretinal membrane

Goldberg,

Waheed,

Duker

2014

Br J Ophthalmol

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“… 15 , 16 Methods for en face imaging have been developed 17 , 18 and applied for visualizing pathologies due to various retinal conditions. 19 – 30 We previously reported methods for generation of en face reflectance images of individual retinal layers from a high-density raster of images. 31 – 33 In the current study, we report for the first time an en face OCT imaging method for quantitative measurements of both thickness and reflectance alterations in individual retinal layers and macular subfields at different stages of DR.…”

mentioning

confidence: 99%

Alterations in Retinal Layer Thickness and Reflectance at Different Stages of Diabetic Retinopathy by En Face Optical Coherence Tomography

Wanek

Blair

Chau

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeThis article reports a method for en face optical coherence tomography (OCT) imaging and quantitative assessment of alterations in both thickness and reflectance of individual retinal layers at different stages of diabetic retinopathy (DR).MethodsHigh-density OCT raster volume scans were acquired in 29 diabetic subjects divided into no DR (NDR) or non-proliferative DR (NPDR) groups and 22 control subjects (CNTL). A customized image segmentation method identified eight retinal layer interfaces and generated en face thickness maps and reflectance images for nerve fiber layer (NFL), ganglion cell and inner plexiform layers (GCLIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor outer segment layer (OSL), and retinal pigment epithelium (RPE). Mean thickness and intensity values were calculated in nine macular subfields for each retinal layer.ResultsEn face thickness maps and reflectance images of retinal layers in CNTL subjects corresponded to normal retinal anatomy. Total retinal thickness correlated negatively with age in nasal subfields (R ≤−0.31; P ≤ 0.03, N = 51). In NDR subjects, NFL and OPL thickness were decreased (P = 0.05), and ONL thickness was increased (P = 0.04) compared to CNTL. In NPDR subjects, GCLIPL thickness was increased in perifoveal subfields (P < 0.05) and INL intensity was higher in all macular subfields (P = 0.04) compared to CNTL.ConclusionsDepth and spatially resolved retinal thickness and reflectance measurements are potential biomarkers for assessment and monitoring of DR.

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“…4 The presence of retinal changes following ERM surgery has been reported by SD-OCT images. The most recent description of a novel postoperative sign is the presence of delayed cystic changes in the inner nuclear layer.…”

Section: Introductionmentioning

confidence: 99%

“…3 Due to these dye-assisted improvements, ILM peeling is now often performed in addition to ERM removal. 4 However, ILM peeling during ERM surgery is still controversial. 3 Arguments against ILM peeling include possible mechanical trauma to the retinal nerve fiber layer 5 and paracentral scotomas.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Significance of Cystic Changes After Epiretinal Membrane Surgery With Internal Limiting Membrane Removal

Dolz-Marco

Hoang

Gallego-Pinazo

et al. 2016

Retina

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Purpose To assess the prevalence and significance of cystic changes after internal limiting membrane (ILM) peeling during epiretinal membrane (ERM) surgery. Methods A retrospective review was performed on 64 patients who underwent pars plana vitrectomy (PPV) with membranectomy for idiopathic ERM between January 2010 and January 2012 by a single physician. PPV alone (Group 1, n=32) or in combination with phacoemulsification (Group 2, n=32) were performed. Peeling of the ERM was assisted by triamcinolone, and ILM was peeled up to the vascular arcades with the aid of brilliant blue dye. Results In Group 1, BCVA in logMAR (Snellen) improved from 0.53±0.29 (20/68) at baseline to 0.23±0.22 (20/34) at 6-month follow-up (p<0.001). Two cases (6.3%) developed new cystic changes within the inner nuclear layer (INL); however, there was no significant difference in BCVA at 6-months (p=0.475). In Group 2, BCVA improved from 0.41±0.17 (20/51) at baseline to 0.18±0.15 (20/30) at 6-months (p<0.001). Eight cases (25%) developed new INL cystic changes; however, there was no significant difference in BCVA at 6-months (p=0.894). Conclusions Development of new INL cystic changes following ERM surgery may be a frequent finding, but in contrast to cystoid macular edema, does not appear to affect visual recovery and should be observed. The combination of PPV with cataract extraction may increase the risk of INL cystic changes.

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Retinal Surface en Face Optical Coherence Tomography

Cited by 36 publications

References 20 publications

Optical coherence tomography in the preoperative and postoperative management of macular hole and epiretinal membrane

Optical coherence tomography in the preoperative and postoperative management of macular hole and epiretinal membrane

Alterations in Retinal Layer Thickness and Reflectance at Different Stages of Diabetic Retinopathy by En Face Optical Coherence Tomography

Assessment of the Significance of Cystic Changes After Epiretinal Membrane Surgery With Internal Limiting Membrane Removal

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