Retinal stem/progenitor properties of iris pigment epithelial cells

Sun, Guangwei; Asami, Maki; Ohta, Hiroshi; Kosaka, Jun; Kosaka, Mitsuko

doi:10.1016/j.ydbio.2005.10.035

Cited by 72 publications

(57 citation statements)

References 37 publications

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“…Interestingly, all 121 samples had positive JARID1B staining in the ciliary body epithelium. It has been suggested in the literature that progenitor cells do exist in the epithelium of the ciliary body, [49][50][51][52] which this study substantiates as JARID1B is thought to be a marker for stem/progenitor cells. 24 With regard to the recent study by Roesch et al that studied JARID1B expression in cutaneous melanoma, 24 study data did not support the hypothesis that JARID1B is an independent predictive factor for UM survival.…”

Section: Discussionsupporting

confidence: 82%

JARID1B Protein Expression and Prognostic Implications in Uveal Melanoma

Radberger

Bykov

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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This study demonstrates that JARID1B is expressed by UM cells. Despite that JARID1B was highly expressed in UM, a statistically significant association (P < 0.05) between JARID1B expression and OS could not be obtained. However, a P-value of 0.06 could suggest that high JARID1B expression is correlated with lower survival; thus, a follow up study with a greater patient sample is recommended. In addition, samples of tumors characterized by high invasiveness showed a higher JARID1B expression. Furthermore, this study substantiates the presence of progenitor cells in the ciliary body epithelium.

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Section: Discussionsupporting

confidence: 82%

JARID1B Protein Expression and Prognostic Implications in Uveal Melanoma

Radberger

Bykov

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…These muscles develop from the underlying ectoderm of the optic cup. In the adult the iris is formed by the pigment-containing external layer with the unpigmented internal layer of the optic cup, and a layer of richly vascularized connective tissue that contains the pupillary muscles 19,20 .…”

Section: Discussionmentioning

confidence: 99%

A Study of The Histogenesis of Sheep Fetus Iris

Saadatlou¹,

Tavousi²,

Keyhanmanesh³

2013

Kafkas Univ Vet Fak Derg

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SummaryIn this study, for determination of histogenesis of iris in sheep, 32 samples of sheep fetuses at different and certain ages were used. After sample preparation and fixation, their age were determined and histological and anatomical studies were done. In histological studies, the H&E staining and two other specific staining (verhoeff and Masson's Trichrome) were used. Obtained results demonstrated that a two-layered cup formed in first month but iris separation from the anterior and ceca part of retina occurred in second month. The separation of iris from ciliary body was completed in third month. From the beginning of third month, the iris formed changes and its circular shape changed to oval form so that its internal angle was larger than its external angle and this condition was retained until the end of pregnancy. General shape of pupil conformed to general shape of iris. It was histologically revealed that iris was formed from the anterior part of the optic cup just at the connection place of outer and inner layers in second month and thereafter a part of superficial ectoderm and choroid was added to it. The first signs of elastic fibers in iris as well as smooth muscles appearance were significant in second month. The posterior cells are pigmented from the beginning of the iris cell formation. Anterior epithelial tissue of the iris was simple squamous and two layer cuboidal cells formed its posterior epithelium which were stabilized in third month. The number of collagen and elastic fibers and smooth muscles and their size increase with age. Keywords: Iris, Sheep fetus, Histogenesis Koyun Fetus Irisinin Histogenesisi Üzerine Bir Çalışma ÖzetBu çalışmada, koyunlarda iris histogenezinin belirlenmesi için farklı ve belirli yaşlarda 32 adet koyun fetus örneği kullanıldı. Numune hazırlama ve tesbit sonrası, yaş durumları belirlenerek histolojik ve anatomik çalışmalar gerçekleştirildi. Histolojik çalışmalarda, H & E boyama ve diğer iki spesifik boyama (Verhoeff ve Masson's Trichrome) kullanıldı. Elde edilen sonuçlar, iki katmanlı çanak formasyonunun ilk ayda oluşmasına rağmen retinanın anterior ve ceca bölümlerinden iris ayrılmasının ikinci ayda meydana geldiğini gösterdi. İrisin siliyer cisimden ayrılması üçüncü ayda tamamlandı. Üçüncü ayın başından itibaren, iris değişiklikleri oluşmuş ve onun iç açısının dış açısından daha büyük olabilmesi için sirküler şekli oval forma değiştiği ve bu durumun gebeliğin sonuna kadar muhafaza edildiği gözlemlendi. Pupilin genel şekli iris genel şekli ile uyumlu bulundu. Histolojik olarak ortaya çıkan bulguda, iris ikinci ayda dış ve iç katmanların bağlantı yerindeki optik çanağın anterior bölümünü oluşturduğu ve bundan sonra yüzeysel ektodermin bir kısmının ve koroidin buna eklendiği belirlendi. Iris elastik liflerinin yanı sıra düz kasların görünümünün ilk belirtileri ikinci ayda anlamlı bulundu. Posterior hücreler iris hücre formasyonu başlangıcından itibaren pigmentli halde gözlemlendi. Irisin anterior epitel dokusu, üçüncü ayda stabilize olan onun posterior epitelin...

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“…In addition to its important role in IOP establishment and maintenance, the ciliary body also is responsible for synthesizing many proteins of the inner limiting membrane, a structure that is crucial for the survival of retinal ganglion cells (Halfter et al, 2005). Intriguingly, recent studies suggest that the ciliary body and iris harbor cells with stem cell/progenitor characteristics (Ahmad et al, 1999;Tropepe et al, 2000;Sun et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Identification of genes expressed preferentially in the developing peripheral margin of the optic cup

Trimarchi

Cho

Cepko

2009

Developmental Dynamics

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Specification of the peripheral optic cup by Wnt signaling is critical for formation of the ciliary body/iris. Identification of marker genes for this region during development provides a starting point for functional analyses. During transcriptional profiling of single cells from the developing eye, two cells were identified that expressed genes not found in most other single cell profiles. In situ hybridizations demonstrated that many of these genes were expressed in the peripheral optic cup in both early mouse and chicken development, and in the ciliary body/iris at subsequent developmental stages. These analyses indicate that the two cells probably originated from the developing ciliary body/iris. Changes in expression of these genes were assayed in embryonic chicken retinas when canonical Wnt signaling was ectopically activated by CA-␤-catenin. Twelve ciliary body/iris genes were identified as upregulated following induction, suggesting they are excellent candidates for downstream effectors of Wnt signaling in the optic cup. Developmental

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Retinal stem/progenitor properties of iris pigment epithelial cells

Cited by 72 publications

References 37 publications

JARID1B Protein Expression and Prognostic Implications in Uveal Melanoma

JARID1B Protein Expression and Prognostic Implications in Uveal Melanoma

A Study of The Histogenesis of Sheep Fetus Iris

Identification of genes expressed preferentially in the developing peripheral margin of the optic cup

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