Retinal projections into the Zona Incerta of the rock cavy (Kerodon rupestris): A CTb study

Morais, Paulo Leonardo Araújo de Góis; Santana, Melquisedec Abiaré Dantas de; Cavalcante, Judney Cley; Costa, Miriam Stela Maris de Oliveira; Nascimento, Expedito Silva do

doi:10.1016/j.neures.2014.08.016

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Adopting the criteria and nomenclature of Ling et al (1997) and Morais et al (2014) for retinothalamic fiber morphology, we identified three groups of labeled axons based on axon branching patterns and size, morphology, and complexity of bouton arrangement. The retinal fibers in the SCN could be classified as (1) simple en passant varicosities and terminal swellings; these sort of terminals are present in poorly branched fibers decorated with varicosities and swellings of various sizes, with a simple terminal bouton at the end of each branch of the terminal arbor ( Figures 2D,G ); (2) string-like configurations that comprised axon collaterals studded with boutons of various sizes; these swellings occur close together, and beaded collaterals form a longitudinal arrangement in which at least two fibers travel together for a distance ( Figures 2E,H ); and (3) type R2-like terminals (see Ling et al, 1997 ) consisting of rosette-like clusters of boutons of medium and small varicosities that emerge from the fine axon ( Figures 2F,I ).…”

Section: Resultsmentioning

confidence: 99%

The Suprachiasmatic Nucleus and the Intergeniculate Leaflet of the Flat-Faced Fruit-Eating Bat (Artibeus planirostris): Retinal Projections and Neurochemical Anatomy

et al. 2018

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In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN, classically known as the master circadian clock, generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity. Strategies on the use of time by animals can provide important clues about how some species are adapted to competitive process in nature. Few studies have provided information about temporal niche in bats with special attention on the neural substrate underlies circadian rhythms. The aim of this study was to investigate these circadian centers with respect to their cytoarchitecture, chemical content and retinal projections in the flat-faced fruit-eating bat (Artibeus planirostris), a chiropteran endemic to South America. Unlike other species of phyllostomid bats, the flat-faced fruit-eating bat’s peak of activity occurs 5 h after sunset. This raises several questions about the structure and function of the SCN and IGL in this species. We carried out a mapping of the retinal projections and cytoarchitectural study of the nuclei using qualitative and quantitative approaches. Based on relative optical density findings, the SCN and IGL of the flat-faced fruit-eating bat receive bilaterally symmetric retinal innervation. The SCN contains vasopressin (VP) and vasoactive intestinal polypeptide (VIP) neurons with neuropeptide Y (NPY), serotonin (5-HT) and glutamic acid decarboxylase (GAD) immunopositive fibers/terminals and is marked by intense glial fibrillary acidic protein (GFAP) immunoreactivity. The IGL contains NPY perikarya as well as GAD and 5-HT immunopositive terminals and is characterized by dense GFAP immunostaining. In addition, stereological tools were combined with Nissl stained sections to estimate the volumes of the circadian centers. Taken together, the present results in the flat-faced fruit-eating bat reveal some differences compared to other bat species which might explain the divergence in the hourly activity among bats in order to reduce the competitive potential and resource partitioning in nature.

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Section: Resultsmentioning

confidence: 99%

The Suprachiasmatic Nucleus and the Intergeniculate Leaflet of the Flat-Faced Fruit-Eating Bat (Artibeus planirostris): Retinal Projections and Neurochemical Anatomy

et al. 2018

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“…The ZI is connected with nearly every neural center of the neuro-axis, from cerebral cortex to spinal cord [1], and even receives projections from the retina [24]. Its principal connections are with the cerebral cortex, diencephalon, and brainstem.…”

Section: Introductionmentioning

confidence: 99%

Whole-Brain Connectome of GABAergic Neurons in the Mouse Zona Incerta

et al. 2022

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The zona incerta (ZI) is involved in various functions and may serve as an integrative node of the circuits for global behavioral modulation. However, the long-range connectivity of different sectors in the mouse ZI has not been comprehensively mapped. Here, we obtained whole-brain images of the input and output connections via fluorescence micro-optical sectioning tomography and viral tracing. The principal regions in the input-output circuits of ZI GABAergic neurons were topologically organized. The 3D distribution of cortical inputs showed rostro-caudal correspondence with different ZI sectors, while the projection fibers from ZI sectors were longitudinally organized in the superior colliculus. Clustering results show that the medial and lateral ZI are two different major functional compartments, and they can be further divided into more subdomains based on projection and input connectivity. This study provides a comprehensive anatomical foundation for understanding how the ZI is involved in integrating different information, conveying motivational states, and modulating global behaviors.

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“…At high magnification, the appearance of retino-dLGN axon arbors in A. planirostris resembles that of other terminal specializations of retinofugal axons in the mediodorsal thalamic nucleus, Zona Incerta of the rock cavy and suprachiasmatic hypothalamic nucleus of the A. planirostris (do Nascimento et al, 2010 ; de Góis Morais et al, 2014 ; Santana et al, 2018 ). R1/R2 types terminals observed in the superficial layer of the dLGN in the A. planirostris have a morphology dramatically distinct, by virtue of their large-sized boutons and rosette-like configuration, from terminals found in the deep layer of the dLGN.…”

Section: Discussionmentioning

confidence: 84%

Retinofugal Projections Into Visual Brain Structures in the Bat Artibeus planirostris: A CTb Study

et al. 2018

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A well-developed visual system can provide significant sensory information to guide motor behavior, especially in fruit-eating bats, which usually use echolocation to navigate at high speed through cluttered environments during foraging. Relatively few studies have been performed to elucidate the organization of the visual system in bats. The present work provides an extensive morphological description of the retinal projections in the subcortical visual nuclei in the flat-faced fruit-eating bat (Artibeus planirostris) using anterograde transport of the eye-injected cholera toxin B subunit (CTb), followed by morphometrical and stereological analyses. Regarding the cytoarchitecture, the dorsal lateral geniculate nucleus (dLGN) was homogeneous, with no evident lamination. However, the retinal projection contained two layers that had significantly different marking intensities and a massive contralateral input. The superior colliculus (SC) was identified as a laminar structure composed of seven layers, and the retinal input was only observed on the contralateral side, targeting two most superficial layers. The medial pretectal nucleus (MPT), olivary pretectal nucleus (OPT), anterior pretectal nucleus (APT), posterior pretectal nucleus (PPT) and nucleus of the optic tract (NOT) were comprised the pretectal nuclear complex (PNT). Only the APT lacked a retinal input, which was predominantly contralateral in all other nuclei. Our results showed the morphometrical and stereological features of a bat species for the first time.

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Retinal projections into the Zona Incerta of the rock cavy (Kerodon rupestris): A CTb study

Cited by 7 publications

References 26 publications

The Suprachiasmatic Nucleus and the Intergeniculate Leaflet of the Flat-Faced Fruit-Eating Bat (Artibeus planirostris): Retinal Projections and Neurochemical Anatomy

The Suprachiasmatic Nucleus and the Intergeniculate Leaflet of the Flat-Faced Fruit-Eating Bat (Artibeus planirostris): Retinal Projections and Neurochemical Anatomy

Whole-Brain Connectome of GABAergic Neurons in the Mouse Zona Incerta

Retinofugal Projections Into Visual Brain Structures in the Bat Artibeus planirostris: A CTb Study

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