Retinal Pigment Epithelial Wound Healing in vivo

Lopez, P.; Yan, Qifeng; Kohen, Leon; Rao, N. Purnachandra; Black, Joseph T.; Oganesian, Arutun

doi:10.1097/00006982-199616020-00025

Cited by 4 publications

(4 citation statements)

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“…Del developed a model to study the effects of RPE debridement on the overlying retina and underlying choriocapillaris in the domestic pig, and reported that previously debrided areas of Bruch's membrane were covered by a layer of hypopigmented RPE in most areas, and that the choriocapillaris, inner retina and the outer nuclear layer were intact in areas containing RPE after 1 month. This re-epithelialization of Bruch's membrane by a monolayer of depigmented RPE cells after RPE debridement was also observed by Lopez et al (1994) in their rabbit experiment. Thus, attempts at removing RPE from the base of the hole may irritate adjacent tissues and promote release of growth factors that induce sliding migration or proliferation of adjacent RPE and chorioretinal adhesion.…”

Section: Discussionsupporting

confidence: 69%

Effect of debridement of the retinal pigment epithelium in full‐thickness macular hole surgery

Nao‐i

Sawada

1998

Acta Ophthalmologica Scandinavica

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ABSTRACT. We assessed the efficacy of debridement of the retinal pigment epithelium (RPE) from the base of the macular hole during vitrectomy to treat 83 eyes of 75 patients with a stage 2 (nΩ29), stage 3 (nΩ35) or stage 4 (nΩ19) macular hole. Patients ranged in age from 51 to 77 years (mean, 67.6 years). Duration of symptoms preoperatively ranged from 1 to 120 months (average, 19.2 months). During vitrectomy for macular hole, the RPE at the base of the hole was gently aspirated with either a silicone-tipped extrusion needle or a blunt-tipped 27-gauge needle. Follow-up averaged 13.0 months (range, 3 to 36 months). The holes resolved in 73 (88%) of the 83 eyes after one surgical procedure. In 73 eyes with a follow-up period of 6 months or more, sixty-five (89%) showed improved VA of at least two lines of Snellen equivalent. Fifty-five (75%) eyes had a visual acuity (VA) of Ø20/40. Our preliminary results suggest that RPE debridement from the base of the hole is a useful adjunct to vitrectomy for treating full-thickness macular holes.

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Section: Discussionsupporting

confidence: 69%

Effect of debridement of the retinal pigment epithelium in full‐thickness macular hole surgery

Nao‐i

Sawada

1998

Acta Ophthalmologica Scandinavica

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“…Debridement results in an immediate loss of RPE cells followed by rapid repopulation of the RPE layer within weeks. This in situ wound-repair involves migration and proliferation of neighboring RPE cells to fill in the defect 43,44 in a process that mirrors in vitro self-repair of the RPE monolayer.…”

Section: Rpe Cell Proliferation In Vivomentioning

confidence: 99%

Retinal pigment epithelial cell proliferation

Stern

Temple

2015

Exp Biol Med (Maywood)

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The human retinal pigment epithelium forms early in development and subsequently remains dormant, undergoing minimal proliferation throughout normal life. Retinal pigment epithelium proliferation, however, can be activated in disease states or by removing retinal pigment epithelial cells into culture. We review the conditions that control retinal pigment epithelial proliferation in culture, in animal models and in human disease and interpret retinal pigment epithelium proliferation in context of the recently discovered retinal pigment epithelium stem cell that is responsible for most in vitro retinal pigment epithelial proliferation. Retinal pigment epithelial proliferation-mediated wound repair that occurs in selected macular diseases is contrasted with retinal pigment epithelial proliferation-mediated fibroblastic scar formation that underlies proliferative vitreoretinopathy. We discuss the role of retinal pigment epithelial proliferation in age-related macular degeneration which is reparative in some cases and destructive in others. Macular retinal pigment epithelium wound repair and regression of choroidal neovascularization are more pronounced in younger than older patients. We discuss the possibility that the limited retinal pigment epithelial proliferation and latent wound repair in older age-related macular degeneration patients can be stimulated to promote disease regression in age-related macular degeneration.

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“…RPE cell flattening is observed as a normal process during ocular development (Ts'o and Friedman, 1968 ;Streeten, 1969), in eyes with glaucoma (Ueno and Naumann, 1989), in AMD (Green, McDonnel and Yeo, 1985 ;Sarks 1976 detachment (Machemer and Laqua, 1975), and in wound healing following thermal injury (Apple, 1977 ;Lincoff and Kreissig, 1979) or localized RPE debridement (Heriot and Machemer 1992 ;Lopez et al, 1995 ;Leonard et al, 1997 ;Valentino et al, 1995 ;Del Priore et al, 1995). This morphology also characterizes human RPE growing on plastic (Israel et al, 1980 ;Del Monte and Maumenee, 1981 ;Campochiaro and Hackett, 1993).…”

Section: Discussionmentioning

confidence: 98%