Retinal pigment epithelial tears

Sastre-Ibáñez, M.; Martínez-Rubio, C.; Molina-Pallete, R.; López-Corell, P. Martínez; Wu, Lijuan; Arévalo, J. Fernando; Gallego-Pinazo, Roberto

doi:10.1016/j.jfo.2018.04.017

Cited by 15 publications

(19 citation statements)

References 72 publications

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“…RPE tears are a well-known complication of nAMD [67]. In the large majority of cases (86.2%-100%), RPE tears occur in patients with preexisting PEDs [68]. RPE tears could occur spontaneously or as a consequence of thermal laser treatment, photodynamic therapy, or anti-VEGF therapy.…”

Section: Retinal Pigment Epithelial Tearsmentioning

confidence: 99%

“…RPE tears could occur spontaneously or as a consequence of thermal laser treatment, photodynamic therapy, or anti-VEGF therapy. e size and recent onset (<4.5 months) of PED are potential risk factors for developing RPE tears [68]. Moreover, different morphologies of PED additionally increase the risk of developing an RPE tear.…”

Section: Retinal Pigment Epithelial Tearsmentioning

confidence: 99%

“…As the grade of the RPE rip increases, OCT shows a wider patch of RPE loss with the redundant RPE taking on a dome-shaped configuration [78]. e retracted RPE is observed with an irregular contour, dense hyperreflectivity from duplication of the RPE, and a shadowing effect beneath it [68,77]. e overlying neurosensory retina remains intact with or without neurosensory detachment.…”

Section: Retinal Pigment Epithelial Tearsmentioning

confidence: 99%

“…However, the evidence points to continuing (or starting) anti-VEGF treatment, which seems to reduce the development of fibrosis and decreases the risk of disciform scar development. In the presence of an active CNV, anti-VEGF injections should be repeated until the underlying disease has been resolved [68,77,83]. Invernizzi et al suggested that long-term visual outcomes in eyes affected by an RPE tear may be mostly related to the patient's response to therapy than to the tear itself [67].…”

Section: Retinal Pigment Epithelial Tearsmentioning

confidence: 99%

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OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review

Metrangolo

Donati

Mazzola

et al. 2021

Journal of Ophthalmology

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Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly people. Neovascular AMD (nAMD) is responsible for the majority of cases of severe visual loss in eyes with AMD. Optical coherence tomography (OCT) is the most widely used technology for the diagnosis and follow-up of nAMD patients, which is widely used to study and guide the clinical approach, as well as to predict and evaluate treatment response. The aim of this review is to describe and analyze various structural OCT-based biomarkers, which have practical value during both initial assessment and treatment follow-up of nAMD patients. While central retinal thickness has been the most common and one of the first OCT identified biomarkers, today, other qualitative and quantitative biomarkers provide novel insight into disease activity and offer superior prognostic value and better guidance for tailored therapeutic management. The key importance of retinal fluid compartmentalization (intraretinal fluid, subretinal fluid, and subretinal pigment epithelium (RPE) fluid) will be discussed firstly. In the second part, the structural alterations of different retinal layers in various stages of the disease (photoreceptors layer integrity, hyperreflective dots, outer retinal tubulations, subretinal hyperreflective material, and retinal pigment epithelial tears) will be analyzed in detail. The last part of the review will focus on how alterations of the vitreoretinal interface (vitreomacular adhesion and traction) and of the choroid (sub-RPE hyperreflective columns, prechoroidal clefts, choroidal caverns, choroidal thickness and choroidal volume, and choroidal vascular index) interact with nAMD progression. OCT technology is evolving very quickly, and new retinal biomarkers are continuously described. This up-to-date review article provides a comprehensive description on how structural OCT-based biomarkers provide a valuable tool to monitor the progression of the disease and the treatment response in nAMD patients. Thus, in this perspective, clinicians will be able to allocate hospital resources in the best possible way and tailor treatment to the individual patient’s needs.

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Section: Retinal Pigment Epithelial Tearsmentioning

confidence: 99%

Section: Retinal Pigment Epithelial Tearsmentioning

confidence: 99%

Section: Retinal Pigment Epithelial Tearsmentioning

confidence: 99%

Section: Retinal Pigment Epithelial Tearsmentioning

confidence: 99%

See 2 more Smart Citations

OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review

Metrangolo

Donati

Mazzola

et al. 2021

Journal of Ophthalmology

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“…While RPE tears may occur in the setting of a serous PED with or without evidence of contiguous MNV, these lesions may occasionally develop in eyes with exudative neovascular AMD without serous PED in the presence of large areas of hemorrhage [47-50]. Overall, the incidence of RPE tears ranges from 0.4 to 27% in cases of neovascular AMD [51, 52]. Notably, RPE tears usually occur in treatment-naive eyes or, eventually, they may complicate eyes soon after starting treatment, assuming that most RPE tears manifest within 3 months after the initiation of anti-VEGF therapy [53].…”

Section: Complications Of Neovascular Amdmentioning

confidence: 99%

Complications Associated with Worse Visual Outcomes in Patients with Exudative Neovascular Age-Related Macular Degeneration

et al. 2021

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Background: Neovascular age-related macular degeneration (AMD) represents a leading cause of vision loss in older subjects. The introduction of anti-vascular endothelial growth factor therapy has enormously improved the visual prognosis in these patients. Summary: However, severe complications may still occur in this disease and their development may significantly affect short- and long-term visual outcomes. Key Messages: In this article, we provided a review of these complications, highlighting their distinctive signs or symptoms and focusing on the current evidence of treatment. To place the complications related to neovascular AMD in a proper context, this review deals with core components essential for proper comprehension of neovascular AMD that includes pathogenesis, clinical signs, and basic principles of treatment.

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