Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

Lommatzsch, Claudia; Rothaus, Kai; Koch, Jörg; Heinz, Carsten; Grisanti, Salvatore

doi:10.1007/s10792-019-01107-7

Cited by 23 publications

(43 citation statements)

References 28 publications

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“…14 Nevertheless, at 6 and 12 months postoperatively there was no significant thinning in the mean RNFLT either per sectors or on average as compared to baseline. 13,14,19,21 RNFLT-increase in the early postoperative period might be attributed to the major IOPreduction encountered during this period, although we could find no correlation between these two parameters.…”

Section: Discussioncontrasting

confidence: 60%

“…In these studies, it is suggested that the thickness of prelaminar tissue is influenced by IOP. 13,15,[19][20][21] According to research articles about NPDS, postoperative IOP-reduction is not associated with significant RNFLT-change at 6 months postoperatively. 13,14 Studies reporting on the condition of lamina cribrosa and peripapillary RNFLT after trabeculectomy or NPDS draw the same conclusion: changes in the morphology of the optic nerve head attributable to postoperative IOP-changes (anterior displacement of the lamina cribrosa, reduced cup volume and increased rim area) are not necessarily accompanied by an increase in the RNFLT.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 Studies reporting on the condition of lamina cribrosa and peripapillary RNFLT after trabeculectomy or NPDS draw the same conclusion: changes in the morphology of the optic nerve head attributable to postoperative IOP-changes (anterior displacement of the lamina cribrosa, reduced cup volume and increased rim area) are not necessarily accompanied by an increase in the RNFLT. 4,17,[21][22][23][24] Reduction of cup volume can be detected if significant IOP lowering (according to some authors at least 30% or according to others even less) is realized. 13,22,25 Changes in RNFLT in correlation with IOP changes were likewise measured.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Retinal Nerve Fibre Layer Thickness Change After CO2 Laser-Assisted Deep Sclerectomy Surgery</p>

Sohajda¹,

Széll²,

Revák³

et al. 2020

OPTH

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The goal of our study was to investigate changes in intraocular pressure (IOP), best-corrected visual acuity (BCVA), and retinal nerve fibre layer thickness (RNFLT) after CO2 laser-assisted deep sclerectomy (CLASS). Methods: We carried out uncomplicated CLASS surgeries and a 12-month follow-up on 22 open-angle glaucomatous (OAG) eyes of 22 patients. IOP, BCVA, and RNFLT with spectraldomain optical coherence tomography (SD OCT) were recorded before and 1, 3, 6, 12 months after surgery. Results: Mean age of patients was 68.1 years. IOP decreased from preoperative 28.45±5.99 SD mmHg (mean±standard deviation) to 15.09±2.40 mmHg (p=0.00039) at 12 months after surgery. BCVA-change from preoperative 0.34±0.38 SD (LogMAR) to 0.37±0.41 SD (LogMAR) was not significant (p=0.2456). RNFLT-change from preoperative 60.50 ±18.15µm to 59.63±17.52 µm at 12 months postoperatively was not significant (p=0.056). Qualified success rate of CLASS surgery was 72.7%, whereas complete success rate was 64% at 1 year postoperatively. Conclusion: Successful CLASS surgery efficiently reduced IOP. At postoperative 12 months, RNFLT and BCVA were not reduced significantly. There was no significant glaucomatous progression after surgery encountered in respect of investigated parameters.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Retinal Nerve Fibre Layer Thickness Change After CO2 Laser-Assisted Deep Sclerectomy Surgery</p>

Sohajda¹,

Széll²,

Revák³

et al. 2020

OPTH

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“…Other anatomical changes that occur in glaucoma are: retinal ganglion cells axons injury; thinning of the retinal nerve fiber layer (RNFL) thickness; intrapapillary fibers loss (“cupping”); posterior displacement of the lamina cribrosa. These complex modifications probably lead to circulatory changes, resulting in an ischemic insult [26,27].…”

Section: Introductionmentioning

confidence: 99%

Papillary Vessel Density Changes After Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study

Nicolai

Franceschi

Turris

et al. 2019

JCM

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Purpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eyes of 18 hypertensive patients affected by CRVO before and after the loading-phase of intravitreal Ranibizumab (IVR) injections. Data were quantitatively measured by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) before as well as 1 month and 4 months after injections. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA was assessed. Results: 18 eyes of 18 consecutive patients with a known history of arterial hypertension and affected by an acute CRVO episode were enrolled. Central macular thickness (CMT) was significantly reduced after IVR injections (p < 0.001), while mean BCVA improved from 0.70 ± 0.26 logarithm of the minimal angle of resolution (logMAR) units at baseline to 0.25 ± 0.18 logMAR units after 4 months (p < 0.001). VD inside disc and peripapillary significantly increased (p < 0.001 and p = 0.01, respectively) after treatment. Conclusions: OCTA showed VD increase in the papillary area in patients affected by CRVO after anti-VEGF therapy. This area could represent a new region of interest to study microvasculature changes concomitant with severe macular edema.

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“…Der Sehnervenkopf-Scan wurde durchgeführt im Segmentierungsbereich der oberflächlichen Nervenfaserschicht, vom Hersteller als "radial peripapillary capillaries" (RPC) bezeichnet, die einer Ausdehnung von der ILM bis zur hinteren Begrenzung der Nervenfaserschicht entspricht. Die genauen Einteilungen der Segmentierungen können nachgelesen werden [10]. Die foveale avaskuläre Zone (FAZ) wurde als Kombination dieser beiden Plexus berechnet und wird vom Hersteller als Segmentierungsebene "Retina" bezeichnet (ILM bis OPL + 10 µm).…”

Section: Untersuchungenunclassified

Verändert sich die foveale avaskuläre Zone beim Glaukom?

Lommatzsch

Heinz

Koch

et al. 2020

Klin Monbl Augenheilkd

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Zusammenfassung Hintergrund Vergleichende Beurteilung der fovealen avaskulären Zone (FAZ) mit ihrem Umfang und dem Azirkularitätsindex (AI) sowie der umgebenden Vessel Density bei Glaukomaugen im Vergleich zu gesunden Augen mit zusätzlicher Unterteilung nach Gesichtsfelddefekten an verschiedenen Stellen (zentral oder peripher). Material und Methoden Insgesamt wurden die Daten von 128 Augen ausgewertet. Dabei wurden zunächst Glaukomaugen (n = 74) mit gesunden Augen (n = 54) verglichen und im Weiteren Glaukomaugen mit einem zentralen Gesichtsfeldausfall (ZGD, n = 19) von Augen mit einem peripheren Gesichtsfelddefekt (PGD, n = 34) unterschieden. Die FAZ-Fläche, ihr Umfang und die Rundheit sowie die parafoveale Vessel Density (VD) wurden mittels der optischen Kohärenztomografie-Angiografie im oberflächlichen und tiefen Gefäßplexus berechnet. Ergebnisse Glaukomaugen haben im Vergleich zu gesunden Augen keine signifikante Veränderung der FAZ, ihres Umfangs oder der Zirkularität der avaskulären Zone. Unterteilt man jedoch die Glaukomaugen anhand der Gesichtsfeldausfälle, zeigt sich zum einen, dass die Augen mit einem zentralen Ausfall eine signifikant größere FAZ haben als die mit peripheren Ausfällen und dass der Umfang ebenfalls signifikant größer ist. Zum anderen zeigt der AI keinen signifikanten Unterschied in Abhängigkeit von der Lokalisation der Gesichtsfelddefekte. Die makuläre/foveale Vessel Density wird signifikant geringer bei der ZDG-Gruppe. Schlussfolgerungen Im Rahmen einer Glaukomerkrankung vergrößert sich die foveale avaskuläre Zone, wenn eine Zentralisierung des Gesichtsfelddefektes vorliegt und die Vessel Density nimmt im Bereich der Makula signifikant ab.

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Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

Cited by 23 publications

References 28 publications

<p>Retinal Nerve Fibre Layer Thickness Change After CO2 Laser-Assisted Deep Sclerectomy Surgery</p>

<p>Retinal Nerve Fibre Layer Thickness Change After CO2 Laser-Assisted Deep Sclerectomy Surgery</p>

Papillary Vessel Density Changes After Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study

Verändert sich die foveale avaskuläre Zone beim Glaukom?

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