Retinal Oximetry in a Healthy Japanese Population

Nakano, Yüki; Shimazaki, Takeru; Kobayashi, Nobuya; Miyoshi, Yukiko; Ono, Aoi; Kobayashi, Mamoru; Shiragami, Chieko; Hirooka, Kazuyuki; Tsujikawa, Akitaka

doi:10.1371/journal.pone.0159650

Cited by 18 publications

(24 citation statements)

References 32 publications

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“…In our patients with DME, arterial oxygen saturation was 100.3 ± 9.4% and venous oxygen saturation was 56.4 ± 8.9% at baseline, which is higher than the data from the normative database of retinal oximetry in healthy Japanese individuals (Nakano et al. ). The oxygen saturation may be increased in major retinal veins in eyes with diabetic retinopathy, although statistical analysis was not performed.…”

Section: Discussioncontrasting

confidence: 76%

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Ranibizumab treatment improves diabetic macular oedema without influencing retinal oximetry parameters

Takasago

Fujita

Nakano

et al. 2019

Acta Ophthalmologica

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Purpose: To evaluate the effect of ranibizumab on retinal oximetry in eyes with diabetic macular oedema (DME). Methods: In this prospective interventional study, 30 eyes (30 patients) with DME were treated with three-monthly intravitreal ranibizumab injections, followed by pro re nata administration for 12 months. Retinal oximetry was performed using an Oxymap T1. Results: The mean number of injections was 6.6 AE 2.5. No adverse event was observed throughout the study period. Ranibizumab treatments for 12 months improved the macular oedema (p = 0.002) and achieved a recovery of visual acuity (VA; p = 0.011). However, oxygen saturation levels in the major retinal blood vessels, either the arteries or the veins, remained unchanged during the observational period. Arterial oxygen saturation was 100.3 AE 9.4% before treatment and 100.9 AE 10.7% (p = 0.698) at 6 months. Venous oxygen saturation was 56.4 AE 8.9% before treatment and 55.6 AE 8.6% (p = 0.529) at 6 months. In addition, there were no significant changes in diameters of the major retinal arteries and veins. Greater improvement of VA at 12 months was correlated with a smaller number of ranibizumab injections (r = 0.459, p = 0.011). The number of ranibizumab injections during these 12 months correlated with an increased baseline central retinal thickness (r = 0.385, p = 0.035). Conclusion: Ranibizumab treatments for DME improved the macular oedema and achieved VA recovery, but no changes were noted in the retinal oxygen saturation.

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Section: Discussioncontrasting

confidence: 76%

“…Nakano et al. () reported a normative database of retinal oximetry in healthy Japanese subjects, in which the mean retinal oxygen saturation was 97.0 ± 6.9% in arteries and 52.8 ± 8.3% in veins.…”

Section: Discussionmentioning

confidence: 99%

Ranibizumab treatment improves diabetic macular oedema without influencing retinal oximetry parameters

Takasago

Fujita

Nakano

et al. 2019

Acta Ophthalmologica

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“…In our patients, the arterial saturation was similar to that reported by Nakano et al However, our patients had slightly higher levels of oxygen saturation in the major retinal veins. Nakano et al11 reported a mean retinal vessel diameter of 124.6±14.4 μm in arteries and 167.3±14.6 μm in veins. In our patients, the mean retinal vessel diameter was 125.2±15.2 μm in arteries and 168.7±14.6 μm in veins.…”

Section: Discussionmentioning

confidence: 99%

The effect of vitreomacular and cataract surgery on oxygen saturation in retinal vessels

Nakano¹,

Manabe²,

Osaka³

et al. 2017

OPTH

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PurposeTo evaluate the effects of vitreomacular and cataract surgery on retinal oximetry in vitreomacular disease.Patients and methodsThirty-eight eyes with epiretinal membrane (ERM) and 15 with idiopathic macular hole (MH) underwent 25 gauge pars plana vitrectomy combined with cataract surgery and intraocular lens implantation. Retinal oximetry was performed using the Oxymap T1 before, 1 month, and 6 months after surgery. Oxymap T1 simultaneously captures monochrome images of the fundus at two different wavelengths of light. Built-in Oxymap Analyzer software measures the oxygen saturation and vessel diameter.ResultsMean arterial oxygen saturation significantly increased from 96.8%±6.2% to 100.2%±5.8% at 1 month and to 99.6%±5.8% at 6 months after surgery (P<0.01). Mean venous oxygen saturation also significantly increased from 54.6%±7.5% to 61.2%±6.4% at 1 month and to 62.6%±5.9% at 6 months after surgery (P<0.01). Mean arteriovenous (A-V) difference decreased from 42.2%±6.6% to 39.0%±7.8% at 1 month and to 37.0%±6.9% at 6 months after surgery (P<0.01). The ERM and MH groups showed similar changes in retinal oxygen saturation. However, there were no significant changes in the caliber of major retinal vessels after surgery (from 125.2±15.2 μm to 124.0±15.4 μm in artery, from 168.7±14.6 μm to 169.8±14.6 μm in vein).ConclusionOxymap T1 was able to measure the increase in oxygen saturation in retinal arteries and veins, which led to a decrease in the A-V difference in oxygen saturation after vitrectomy combined with cataract surgery.

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“…; Nakano et al. ) and others reporting a decrease in oxygen saturation with age in healthy subjects (Geirsdottir et al. ; Jani et al.…”

Section: Discussionmentioning

confidence: 89%

Retinal oxygen saturation as a non‐invasive estimate for mixed venous oxygen saturation and cardiac output

Keer

Breda

et al. 2018

Acta Ophthalmologica

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Purpose: To investigate the correlation between retinal vessel oxygen saturation and mixed venous oxygen saturation (SvO 2-mixed ) and cardiac output (CO). Methods: Retinal arterial (SaO 2-retinal ) and venous (SvO 2-retinal ) oxygen saturation were measured non-invasively with dual-wavelength retinal oximetry in subjects receiving invasive measurements of SvO 2-mixed and CO through right heart catheterization. Correlations were analysed using Spearman's rank correlation coefficients and linear regression models. Results: Fourteen patients (median age 62.7 years, range: 21-77) were included in the analysis. When adjusted for age, SvO 2-retinal showed a positive correlation with SvO 2-mixed (b = 0.80, p = 0.003). Retinal arteriovenous oxygen saturation difference was significantly correlated with the inverse of CO (Spearman's q = 0.59, p = 0.026). Conclusion: This pilot study provides proof of concept for the use of retinal oximetry as a non-invasive tool to assess systemic cardiovascular function.

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Retinal Oximetry in a Healthy Japanese Population

Cited by 18 publications

References 32 publications

Ranibizumab treatment improves diabetic macular oedema without influencing retinal oximetry parameters

Ranibizumab treatment improves diabetic macular oedema without influencing retinal oximetry parameters

The effect of vitreomacular and cataract surgery on oxygen saturation in retinal vessels

Retinal oxygen saturation as a non‐invasive estimate for mixed venous oxygen saturation and cardiac output

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