Retinal origin of VECP delays as revealed by simultaneously recorded ERG to patterned stimuli

Lorenz, R.; Heider, Wolfgang

doi:10.1007/bf00142593

Cited by 4 publications

(4 citation statements)

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“…In 90% of the patients they found statistically significant VECP delays from the affected eyes while only 30% had statistically significant reductions in amplitude during the active stage. Lorenz & Heider (1990) also reported much greater delay in eyes with macular disease, finding approximately 20 ms of delay compared with that of normal controls. They studied pattern electroretinograms (ERGs) simultaneously.…”

Section: Discussionmentioning

confidence: 85%

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How are macular changes reflected in pattern visually evoked cortical potentials?

Shimada

Murayama

1997

Acta Ophthalmologica Scandinavica

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ABSTRACT. To investigate the macular contribution to the amplitude and latency of pattern visual evoked cortical potentials (PVECPs), we recorded PVECPs in patients with unilateral macular disease (retinal diseases involving the macular region) and optic neuritis. We selected patients with visual acuities better than 0.3, which is thought to be the minimum acuity to provide clearly discernible responses. The visual stimulus was a checkerboard. We vaned the check size in 4 steps as 7, 14, 28, and 56 min of arc, and the contrast was 20% or 80%. The amplitude of the sinusoidal wave of steady-state VECPs (12 Hz) and the PlOO component of a transient VECP (3 Hz) were measured. Significant attenuation and delay of PVECPs in the affected eye were found in the macular disease group. Macular disease may cause an increase of VECP latency. However, VECP seemed to be a more sensitive test of optic nerve disease than of macular disease, when patients had similar visual acuities.

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Section: Discussionmentioning

confidence: 85%

“…The VECP studies on macular diseases, however, are incomplete. So far, several authors (Lennerstrand 1982;Papakostopoulos et al 1984;Folk et al 1984;Han et al 1985;Celesia & Kaufman 1985;Bass et al 1985;Sherman et al 1986;Johnson et al 1987;Lorenz & Heider 1990;Fujimoto & Adachi-Usami 1991) have reported delays of PI00 latency in patients with macular disease.…”

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confidence: 99%

How are macular changes reflected in pattern visually evoked cortical potentials?

Shimada

Murayama

1997

Acta Ophthalmologica Scandinavica

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“…Since his report, several authors have examined VECP in macular disease. The attenuation of amplitude alone (Smith et al 1990; Kato et al 1991; Mehta et al 1992), the delay of P100 component alone (Lennerstrand 1982; Junghardt et al 1995; Celesia et al 1985; Papakostopoulos et al 1984; Folk et al 1984; Bass et al 1985; Han et al 1985; Sherman et al 1986; Lorenz & Heider 1990), and both abnormalities concomitantly (Johnson et al 1987; Bemelmans et al 1997; Shimada et al 1997) have been reported. When those study results were summarized, VECP delays from 10 to 20 ms were found in patients with macular disease.…”

Section: Discussionmentioning

confidence: 97%

Visual evoked potentials in relation to visual acuity in macular disease

Negishi

Takasoh

Fujimoto

et al. 2001

Acta Ophthalmologica Scandinavica

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Results: Patients with macular disease produced significant delay of P100 latency and amplitude attenuation of the steady-state VECP, as compared with healthy subjects. P100 latency delay was less in patients with macular disease than in those with optic neuritis, while the attenuation rate of the steady-state VECP amplitude was similar between groups. Visual acuity was correlated with P100 latency and steady-state VECP amplitude reduction. Conclusions: Although the delay of latency was less in patients with macular disease than in those with optic neuritis, the electrophysiologic alterations that occur in macular disease demonstrate a potential for diagnostic value at the level of the retina.

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“…It is generally accepted that the flash VECP is not a good tool for assessing visual acuity while the pattern VECP is a sensitive test for determination of visual acuity. Differentiation between retinal and post-retinal disorders as underlying reduced visual acuity can be achieved with simultaneous recording of pattern ERG and VECP [5,6]. However, the use of the VECP alone in order to differentiate between different causes of reduced visual acuity is more complex.…”

Section: Introductionmentioning

confidence: 99%

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Perlman

Segev

Mazawi

et al. 2001

Documenta Ophthalmologica

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The visual evoked cortical potential (VECP) is widely used to verify complaints of reduced visual performance and to identify the site of the disorder. In this study, we investigated the correlation between reduced visual acuity and VECP in volunteers with normal corrected visual acuity and in patients suffering from inherited macular degeneration or from age related macular degeneration (ARMD). Flash evoked VECP was not affected by the visual acuity in the cases of refractive error and in ARMD patients but was reduced in amplitude and delayed in implicit time in the patients suffering from inherited macular degeneration. The VECP elicited by pattern reversal checkerboard (PVECP) was not affected by the quality of the visual image in volunteers with uncorrected refractive error when checks of 60' or larger were used but were considerably reduced in size and prolonged in implicit time for checks smaller than 15'. In both groups of patients suffering from macular dysfunction, pattern reversal VECP was very subnormal and was characterized by prolonged implicit time compared to values expected from their visual acuity. These findings indicate that the PVECP does not directly correlate with visual acuity but rather with foveal function. Therefore, we suggest that recordings of PVECP can be used to differentiate between refractive error and macular disorders as causing reduction in visual acuity when other clinical signs are missing or not available.

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Retinal origin of VECP delays as revealed by simultaneously recorded ERG to patterned stimuli

Cited by 4 publications

References 20 publications

How are macular changes reflected in pattern visually evoked cortical potentials?

How are macular changes reflected in pattern visually evoked cortical potentials?

Visual evoked potentials in relation to visual acuity in macular disease

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