Retinal nerve fibre layer and ganglion cell layer thickness changes following intravitreal aflibercept for age-related macular degeneration

Determination of Vascular Endothelial Growth Factor-B Concentrations in Aqueous Humor and Plasma of Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy Patients Before and After Anti-VEGF Therapy

“…In spite of the beneficial effects, VEGF-A inhibitions had been reported to be associated with geographic atrophy progress, retinal pigment epithelium degeneration, and subsequent retinal neuronal cell apoptosis [5]. Moreover, a quick decrease of the retinal nerve fiber layer thickness had already been observed in patients with nAMD or diabetic macular edema combined with glaucoma undergoing anti-VEGF treatment, demonstrating that VEGF blockage was detrimental to retinal ganglion cell (RGC) survival, especially in individuals already with compromised RGCs [6][7][8].…”