Retinal nerve fiber layer thickness in multiple sclerosis subtypes

Zamzam, Dina; Gaafar, Ayman A; Ismail, A.; Elbassiouny, Ahmed; Tork, Mohamed A.; Hamdy, Haytham

doi:10.4103/1110-1083.162052

Cited by 3 publications

(2 citation statements)

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“…Regarding RNFL thickness measurement, there was decrease in all parameters in RRMS patients compared to control with high statistical significant difference. This is in agreement with other studies Zamzam et al (14) , Khalil et al (15) and Singh et al (16) . Also, Soufi et al (17) evaluated retinal nerve fiber layer thickness measured by optical coherence tomography in patients with multiple sclerosis.…”

Section: Discussionsupporting

confidence: 94%

Evaluation of Retinal Nerve Fiber Layer Thickness in Patients with Multiple Sclerosis

Fahmi¹,

Kamel²,

Salem³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Section: Discussionsupporting

confidence: 94%

Evaluation of Retinal Nerve Fiber Layer Thickness in Patients with Multiple Sclerosis

Fahmi¹,

Kamel²,

Salem³

et al. 2021

The Egyptian Journal of Hospital Medicine

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“…Currently, there is extensive research in evaluating RNFL and macula thickness in MS subtypes. Although this has shown that between subtypes, overall RNFL values and predominantly the temporal quadrant thickness are significantly reduced in SPMS patients compared with RRMS, 24 there is no consistent evidence at present; some have shown good correlation 25 while others have failed to achieve statistical significance. 26 , 27 However, results suggest that retinal axonal damage can occur without clinical ON as a part of MS progression, and OCT can be used as a potential biomarker.…”

Section: Review Of Diseasesmentioning

confidence: 86%

The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

Mukherjee

Al-Fahad²,

Elsherbiny³

2019

Ophthalmol Eye Dis

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Optical coherence tomography is designed to evaluate in vivo qualitative and quantitative changes of the anterior segment, optic nerve and the retina. Initial applications of this technology were confined mainly to ophthalmic diseases. However recently, numerous studies have evaluated its use in systemic conditions and in therapeutics where, optic nerve and retinal architecture can be assessed to monitor progression of systemic conditions and its response to treatment. This is a narrative review aimed at evaluating the debate surrounding the role of spectral domain optical coherence tomography, in systemic conditions where optic nerve affection can be measured and be used in the diagnosis, monitoring and assessment of treatment effect as a non-invasive, quick, novel technique.

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The effect of multiple sclerosis on retinal nerve fiber layer in eyes without history of optic neuritis

Azim

El-Haddad

Osman

2021

The Scientific Journal of Al-Azhar Medical Faculty, Girls

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Background Multiple sclerosis (MS) is a disabling disease that is characterized by an axonal damage in the central nervous system, leading to progressive neurologic deficits. Evidence indicates that axonal damage occurs already in the early stages of the disease. Objective To discover the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) changes using optical coherence tomography in patients with early relapsing-remitting MS [expanded disability status scale (EDSS)<3] and their relation to the degree of disability and duration of the disease. Patients and methods Overall, 48 eyes of 24 patients with relapsing-remitting MS [31 eyes without history of optic neuritis (ON) and 17 with history of ON] were scanned by using optical coherence tomography and compared with 12 eyes of six age-matched and sex-matched healthy participants. Full history taking and neurological and ophthalmological examination was done. In addition, assessment of disability by EDSS was done for patients. Results Both total and sectorial RNFL thickness were significantly decreased in affected eyes (with ON) and nonaffected eyes in comparison with control eyes; however, RNFL thickness (average and sectorial) was not significantly correlated with duration of the disease or disability assessed by EDSS. In contrast, superior and inferior GCC thickness was significantly correlated with EDSS, although they were not significantly decreased in nonaffected eyes in comparison with control eyes. Conclusion RNFL thinning takes place without a historical record of ON and may be considered as a chronic optic neuropathy in patients with MS. GCC thickness is perhaps a reliable marker for indicating progression of disease.

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Retinal nerve fiber layer thickness in multiple sclerosis subtypes

Cited by 3 publications

References 0 publications

Evaluation of Retinal Nerve Fiber Layer Thickness in Patients with Multiple Sclerosis

Evaluation of Retinal Nerve Fiber Layer Thickness in Patients with Multiple Sclerosis

The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

The effect of multiple sclerosis on retinal nerve fiber layer in eyes without history of optic neuritis

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