Retinal Nerve Fiber Layer Thickness in Various Retinal Diseases

Lim, Hyung Bin; Sung, Jae-Yun; Ahn, Seung-Il; Jo, Young–Joon; Kim, Jung‐Yeul

doi:10.1097/opx.0000000000001181

Cited by 18 publications

(14 citation statements)

References 33 publications

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“…Current research has found a correlation between mean RPC density and mean RNFL thickness [34]. Decreasing of RNFL thickness was found with OCT in RVO eyes [32,38,39], suggesting retinal nerve fiber atrophy may be the result of RVO as the disease progressed. In our study, PRC was lower in BRVO eyes compared with fellow eyes, especially in the affected sectors.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

Chen

Yuan

Sun

et al. 2020

Preprint

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Purpose: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. Methods: Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured. Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes (P<0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P<0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes (P<0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes (P<0.05). VD of inside disc in fellow eyes was lower than normal eyes (P<0.05). Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions. Key words: optical coherence tomography angiography, retinal vasculature, foveal avascular zone, radial peripapillary capillary, branch retinal vein occlusion

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Section: Discussionmentioning

confidence: 91%

Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

Chen

Yuan

Sun

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Current research has found that mean RPC density was correlated with mean RNFL thickness [34]. Decreasing of RNFL thickness was found with OCT in RVO eyes [32,38,39], suggesting retinal nerve fiber atrophy may be the result of RVO as the disease progressed. In our study, PRC was lower in BRVO eyes in comparison to fellow eyes, especially in the affected sectors.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO)

et al. 2020

View full text Add to dashboard Cite

Background: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. Methods: Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured. Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes (P < 0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P < 0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes (P < 0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes (P < 0.05). VD of inside disc in fellow eyes was lower than normal eyes (P < 0.05). Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions.

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“…[8][9][10][11] Peripapillary RNFL (pRNFL) thickness, which can be measured easily by spectral-domain optical coherence tomography (SD-OCT), is a reliable and important variable that can be affected by various conditions, including retinal disease, neuroophthalmic disease, and glaucoma. [12][13][14][15][16] Using commercially available software, disease progression can be determined by trend analysis of pRNFL thickness; this analysis can provide important information, especially in patients with glaucoma. Previously, several trend analyses of pRNFL [17][18][19] revealed agerelated loss of pRNFL, which was accelerated by abnormal eye conditions.…”

mentioning

confidence: 99%

Longitudinal Changes in the Peripapillary Retinal Nerve Fiber Layer Thickness of Patients With Type 2 Diabetes

et al. 2019

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IMPORTANCE Type 2 diabetes is expected to accelerate age-related peripapillary retinal nerve fiber layer (pRNFL) loss, but limited information on the rate of reduction in pRNFL thicknesses in patients with type 2 diabetes is available. OBJECTIVE To investigate longitudinal changes in pRNFL thickness in patients with type 2 diabetes, with or without diabetic retinopathy (DR). DESIGN, SETTING, AND PARTICIPANTS A total of 164 eyes of 63 healthy individuals and 101 patients with type 2 diabetes (49 patients without DR [non-DR group] and 52 patients with mild to moderate nonproliferative DR [NPDR group]) were enrolled in this prospective,

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Retinal Nerve Fiber Layer Thickness in Various Retinal Diseases

Cited by 18 publications

References 33 publications

Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)

Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO)

Longitudinal Changes in the Peripapillary Retinal Nerve Fiber Layer Thickness of Patients With Type 2 Diabetes

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