Retinal nerve fiber layer thickness remains unchanged following laser-assisted in situ keratomileusis11The authors have no financial interest in any device or technique described in this paper.

Gurses-Ozden, R.; Liebmann, Jeffrey M.; Schuffner, Danilo; Buxton, Douglas F.; Soloway, Barrie; Ritch, Robert

doi:10.1016/s0002-9394(01)01094-7

Cited by 50 publications

(10 citation statements)

References 17 publications

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“…A series of previous studies regarding the influence of transient intraoperative IOP elevation during LASIK on RNFL thickness, implementing conventional SLP with fixed compensator, reported a postoperative thinning of RNFL, raising considerations concerning the safety of LASIK in patients with glaucoma or glaucoma suspects. Nevertheless, this finding was attributed to alterations in corneal birefringence following LASIK that affected the accuracy of the instrument's readings [ 5 , 14 – 17 ]. This was further supported by similar reports, which using SLP with variable corneal compensator concluded that RNFL actually remained unaffected following LASIK, when compensating individually for changes in corneal birefringence [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…This was further supported by similar reports, which using SLP with variable corneal compensator concluded that RNFL actually remained unaffected following LASIK, when compensating individually for changes in corneal birefringence [ 17 , 18 ]. In addition, more recent studies utilizing OCT analysis found no LASIK induced peripapillary RNFL alterations [ 4 , 5 , 15 , 16 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that the transient IOP elevation during LASIK may result in short-term retinal and optic nerve ischemia, which therefore may compromise the structural and functional integrity of these ocular structures [ 2 , 3 ]. Recent studies, implementing contemporary imaging modalities such as scanning laser polarimetry (SLP) and/or optical coherence tomography (OCT), reported that transient IOP spikes during LASIK have no impact on peripapillary retinal nerve fiber layer (RNFL) thickness [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes

Zivkovic

Jaksic

Giarmoukakis

et al. 2017

BioMed Research International

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Purpose To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. Methods 89 patients (124 eyes) with established myopia range from −3.0 to −8.0 diopters and no associated ocular diseases were included in this study. RNFL and GC-IPL thickness measurements were performed by spectral domain optical coherence tomography (SD OCT) one day before LASIK and at 1 and 6 months postoperatively. Results Mean RNFL thickness prior to LASIK was 93.86 ± 12.17 μm while the first month and the sixth month postoperatively were 94.01 ± 12.04 μm and 94.46 ± 12.27 μm, respectively. Comparing results, there is no significant difference between baseline, one month, and six months postoperatively for mean RNFL (p > 0.05). Mean GC-IPL thickness was 81.70 ± 7.47 μm preoperatively with no significant difference during the follow-up period (82.03 ± 7.69 μm versus 81.84 ± 7.64 μm; p > 0.05). Conclusion RNFL and GC-IPL complex thickness remained unaffected following LASIK intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes

Zivkovic

Jaksic

Giarmoukakis

et al. 2017

BioMed Research International

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Section: Discussionmentioning

confidence: 99%

“…Yet in 2001, Gürses-Özden et al10 came to the conclusion that LASIK does not affect the RNFL thickness, as measured by OCT, SLP, and scanning laser tomography. The authors found that the changes present in the SLP thickness measurements were due to corneal alterations 10. Centonfanti et al11 as well as Zangwill et al12 confirmed these previous findings, and stated that the post-LASIK thinning of RNFL measured using SLP with a fixed corneal compensator can occur due to altered corneal birefringence, and may not actually be present.…”

Section: Discussionmentioning

confidence: 99%

Changes in retinal nerve fiber layer thickness following mechanical microkeratome-assisted versus femtosecond laser-assisted LASIK

Hosny¹,

Zaki²,

Ahmed³

et al. 2013

OPTH

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PurposeTo study the influence of the transient elevation of intraocular pressure during suction in laser-assisted in situ keratomileusis (LASIK) on the retinal nerve fiber layer (RNFL) thickness both in microkeratome assisted and femotsecond (FS) LASIK.Patients and methodsAn interventional case series that included 40 eyes suffering from myopia who were candidates for LASIK. All underwent Wave Front Guided LASIK by the same surgeon using the VisX CustomVue platform. A corneal flap was created in 20 eyes using a mechanical microkeratome Moria M2 (MMK), while the IFS IntraLase™ was used in the remaining 20 eyes. Mean suction time was recorded from “Suction ON” to “Suction OFF” time. Optic cube and RNFL thickness analysis using Spectral Domain Optical Coherence Tomography (SD-OCT) Cirrus-HD was completed before, and 1 month after LASIK.ResultsThe study included 40 eyes of 20 patients. All were females with mean age 33.5 ± 6.4 years. Mean preoperative spherical equivalent was −3.62 ± 2.31D. Average preoperative RNFL thickness was 94.6 ± 12.1μm in MMK group while the postoperative average thickness was 95.1 ± 11.9 um with no statistically significant difference (P-value: 0.37). Average preoperative RNFL thickness was 108.28 ± 8.4 μm in FS group compared to 108.38 ± 11.2 μm in the postoperative average with no statistically significant difference (P-value: 0.94). Mean “Suction ON” to “Suction OFF” time was 22 seconds in the MMK group compared to 41 seconds in the FS group.ConclusionThe rise of intraocular pressure during application of suction ring in LASIK surgery does not affect the RNFL thickness as measured by SD-OCT, whether the flap is created by MMK or FS.

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Measurement of the Magnitude and Axis of Corneal Polarization With Scanning Laser Polarimetry

Weinreb¹

2002

Arch Ophthalmol

124

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Background: Scanning laser polarimetry uses a polarization compensator to isolate corneal birefringence from the birefringence of the retinal nerve fiber layer. This compensator assumes a fixed corneal polarization magnitude (CPM) of 60 nm and a fixed corneal polarization axis (CPA) of 15°in all subjects.Objectives: To measure the CPM and CPA with a scanning laser polarimeter and to determine if the assumed compensation values are representative of those observed in healthy and glaucomatous eyes. Methods:The CPM and CPA were measured in 51 healthy eyes and 55 glaucomatous eyes using a modified scanning laser polarimeter (GDx Nerve Fiber Analyzer; Laser Diagnostic Technologies Inc, San Diego, Calif) with an experimental variable CPM and CPA compensator. The CPM and CPA distributions in healthy and glaucomatous eyes were compared, and the CPM and CPA relationships with age, corneal thickness, and corneal curvature were also investigated. Nasally upward CPA values (in degrees) were recorded as negative; nasally downward CPA values were recorded as positive.Results: The CPM and CPA measurements were normally distributed with many eyes having values different from those assumed by the GDx corneal compensator. For healthy and glaucomatous eyes combined, CPM measurements ranged from 7 nm to 91 nm (mean±SD, 40.0±15.7 nm). The CPA measurements ranged from −13°t o 73°(mean±SD, 24.5°±17.4°). A significant effect of age on CPA was observed when all eyes were combined (R 2 =0.10; P<.001). There were no differences in CPM or CPA between healthy and glaucomatous eyes after adjusting for age. No effects of corneal thickness on CPM (R 2 = 0.04; P = .05) or CPA (R 2 = 0.01; P = .24) or of corneal curvature on CPM (R 2 = 0.002; P = .67) or CPA (R 2 =0.009; P =.34) were observed. Conclusions:The range of CPM and CPA values observed in glaucomatous and healthy eyes suggests that the narrow-band corneal compensator used by the GDx scanning laser polarimeter is inappropriately compensating for anterior segment birefringence in many eyes.

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Retinal nerve fiber layer thickness remains unchanged following laser-assisted in situ keratomileusis11The authors have no financial interest in any device or technique described in this paper.

Cited by 50 publications

References 17 publications

The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes

The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes

Changes in retinal nerve fiber layer thickness following mechanical microkeratome-assisted versus femtosecond laser-assisted LASIK

Measurement of the Magnitude and Axis of Corneal Polarization With Scanning Laser Polarimetry

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