Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: A comparison

Götzinger, Erich; Pircher, Michael; Baumann, Bernhard; Hirn, Cornelia; Vass, Clemens; Hitzenberger, Christoph K.

doi:10.1002/jbio.200710009

Cited by 62 publications

(68 citation statements)

References 36 publications

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“…As can be seen, not just the retardation and thickness, but also the birefringence varies as a function of position, ranging from ~0.07 to 0.14°/µm on average. For a wavelength of 840 nm, this corresponds to a dimensionless birefringence Δn of 1.6 -3.3·10 −4 which is in the range of RNFL birefringence values reported in other studies [104,108,109]. (Fig.…”

Section: Imaging and Quantification Of The Retinal Nerve Fiber Layermentioning

confidence: 52%

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Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

336

241

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Abstract:Optical coherence tomography (OCT) is now a well-established modality for highresolution cross-sectional and three-dimensional imaging of transparent and translucent samples and tissues. Conventional, intensity based OCT, however, does not provide a tissuespecific contrast, causing an ambiguity with image interpretation in several cases. Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the light's polarization state, adding an additional contrast channel and providing quantitative information. In this paper, we review basic and advanced methods of PS-OCT and demonstrate its use in selected biomedical applications. Drexler, and J. G. Fujimoto, eds. (Springer, Cham, 2015), pp. 1137-1162. 6. J. F. de Boer and T. E. Milner, "Review of polarization sensitive optical coherence tomography and Stokes vector determination," J. Biomed. Opt. 7(3), 359-371 (2002). 7. M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Polarization Sensitive Optical Coherence Tomography in the Human Eye," Prog. Retin. Eye Res. 30(6), 431-451 (2011). 8. D. Stifter, "Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography," Appl. Phys. B 88(3), 337-357 (2007). 9. R. C. Jones, "A new calculus for the treatment of optical systems I. Description and discussion of the calculus," J. Opt. Soc. Am. A 31(7), 488-493 (1941). 10. J. J. Gil and E. Bernabeu, "Obtainment of the polarizing and retardation parameters of a non-depolarizing optical system from the polar decomposition of its Mueller matrix," Optik (Stuttg.) 76, 67-71 (1987). 11. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley Interscience, New York, NY, 1983). 12. W. A. Shurcliff and S. S. Ballard, Polarized Light (Van Nostrand, New York, 1964). 13. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. F. de Boer, "In vivo burn depth determination by highspeed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6(4), 474-479 (2001). 14. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11(7), 782-793 (2003). 15. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, "High-speed fiber based polarizationsensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25(18), 1355-1357 (2000). Rylander, "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE J. Sel. Top. Quantum Electron. 5(4), 1159-1167 (1999 Schmidt-Erfurth, and S. Sacu, "Retinal pigment epithelial features in central serous chorioretinopathy identified by polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 57(4), 1595-1603 (2016). 131. C. Schütze, C. Ahlers, M. Pircher, B. Baumann, E. Götzinger, F. Prager, G. Matt, S. Sacu, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Morphologic characteristics of idiopathic juxtafoveal telangiectasia using spectraldomain and po...

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Section: Imaging and Quantification Of The Retinal Nerve Fiber Layermentioning

confidence: 52%

“…PS-OCT can avoid these problems. Retardation and birefringence measurement and imaging of the RNFL were among the first applications of PS-OCT in the eye [65, [103][104][105][106][107][108][109]. Figure 13 shows an example of PS-OCT retardation imaging in the optic nerve head (ONH) region.…”

Section: Imaging and Quantification Of The Retinal Nerve Fiber Layermentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

336

241

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“…Nine different posterior segment SD OCT systems are currently commercially available. There are also reports from separate groups who have designed customized SD OCT devices and software [21][22][23].…”

Section: Spectral-domain Optical Coherence Tomographymentioning

confidence: 99%

Optical coherence tomography imaging in uveitis

et al. 2013

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“…Kemp et al and Dwelle et al fitted RNFL DPPR data in the Poincaré sphere [11,12]. Using an open air PS-OCT system without single mode fiber and an input state that was circularly polarized, Götzinger et al determined the birefringence induced by the RNFL by fitting DPPR data with a linear regression method [13]. They used a histogram of DPPR data obtained near the photoreceptors to determine the maximum DPPR induced by the RNFL.…”

Section: Introductionmentioning

confidence: 99%

Henle fiber layer phase retardation measured with polarization-sensitive optical coherence tomography

Cense

Wang

Lee

et al. 2013

Biomed. Opt. Express

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Abstract:We developed a method based on polarization-sensitive optical coherence tomography (PS-OCT) to quantify the double pass phase retardation (DPPR) induced by Henle fiber layer in three subjects. Measurements of the retina were performed at a mean wavelength of 840 nm using two polarization states that were perpendicular in a Poincaré sphere representation and phase retardation contributions from tissue layers above and below the Henle fiber layer were excluded using appropriately placed reference and measurement points. These points were semiautomatically segmented from intensity data. Using a new algorithm to determine DPPR, the Henle fiber layer in three healthy subjects aged 50-60 years showed elevated DPPR in a concentric ring about the fovea, with an average maximum DPPR for the three subjects of 22.0° (range: 20.4° to 23.0°) occurring at an average retinal eccentricity of 1.8° (range: 1.5° to 2.25°). Outside the ring, a floor of approximately 6.8° was measured, which we show can mainly be attributed to phase noise that is induced in the polarization states. We also demonstrate the method can determine fast axis orientation of the retardation, which is found consistent with the known radial pattern of Henle fibers.

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Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: A comparison

Cited by 62 publications

References 36 publications

Polarization sensitive optical coherence tomography – a review [Invited]

Polarization sensitive optical coherence tomography – a review [Invited]

Optical coherence tomography imaging in uveitis

Henle fiber layer phase retardation measured with polarization-sensitive optical coherence tomography

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