Retinal nerve fiber layer analysis using GDx® in 49 patients with chronic phase DUSN

Garcia, Carlos Alexandre de Amorim; Oliveira, Álisson Giovani Freitas de; Lima, Carlos Eduardo Nunes de; Rocha, Fabiano N.; Filho, Carlos Alexandre de Amorim Garcia

doi:10.1590/s0004-27492006000500002

Cited by 14 publications

(8 citation statements)

References 17 publications

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“…In our case, OCT showed that both retinal nerve fiber layer (RNFL) and macular thickness measurements were severely reduced, suggesting that changes in later stages of disease were secondary to diffuse inflammatory or toxic process involving both the inner and outer retinal layers as well the optic nerve. The reduction of RNFL thickness measurements in patients with DUSN was previously demonstrated in others studies (4)(5) . Many authors have tried to establish the exact location of the nematode in the ocular fundus using non invasive methods but have been unsuccessful (6)(7) .…”

Section: Discussionsupporting

confidence: 71%

Intraretinal worm documented by optical coherence tomography in a patient with diffuse unilateral subacute neuroretinitis: case report

Cunha

Costa-Cunha

Souza³

et al. 2010

Arq. Bras. Oftalmol.

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Section: Discussionsupporting

confidence: 71%

Intraretinal worm documented by optical coherence tomography in a patient with diffuse unilateral subacute neuroretinitis: case report

Cunha

Costa-Cunha

Souza³

et al. 2010

Arq. Bras. Oftalmol.

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“…In patients with late-stage DUSN there is reduced nerve fiber layer thickness 9. ERG can be used to assess the functional status of the retina.…”

Section: Discussionmentioning

confidence: 99%

Diffuse unilateral subacute neuroretinitis in a young boy: a case report

Guan-Fook¹,

Hayati²,

Raja-Azmi³

et al. 2012

OPTH

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We report a case of diffuse unilateral subacute neuroretinitis in a young boy with no clinical visualization of nematode. The diagnosis was made based on clinical findings and detection of Toxocara immunoglobulin G by Western blot test. An 11-year-old Malay boy presented with progressive blurring of vision in the left eye for a duration of 1 year. It was associated with intermittent floaters. Visual acuity in the left eye was 6/45 and improved to 6/24 with pinhole. There was positive relative afferent pupillary defect, impaired color vision, and presence of red desaturation in the left eye. There were occasional cells in the anterior chamber with no conjunctiva injection. Posterior segment examination revealed mild-to-moderate vitritis and generalized pigmentary changes of the retina with attenuated vessels. The optic disk was slightly hyperemic with mild edema. There was presence of multiple, focal, gray-white subretinal lesions at the inferior part of the retina. Full blood picture results showed eosinophilia with detection of Toxocara immunoglobulin G by Western blot test. Investigations for other infective causes and connective tissue diseases were negative. The diagnosis of diffuse unilateral subacute neuroretinitis secondary to Toxocara was made based on clinical findings and laboratory results. He was treated with oral albendazole 400 mg daily for 5 days and oral prednisolone 1 mg/kg with tapering doses over 6 weeks. At 1 month follow-up, the inflammation had reduced, and multiple, focal, gray-white subretinal lesions were resolved; however there was no improvement of vision.

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“…Previous studies reported a reduction in RNFL thickness in patients with late-stage DUSN using the GDx nerve fiber analyzer [6] and Stratus OCT [7, 8]. In a study with 38 patients diagnosed with late-stage DUSN, Gomes et al reported a significant decrease in RNFL thickness and a correlation with the low visual acuity presented by these patients [7].…”

Section: Discussionmentioning

confidence: 99%

Spectral Domain Optical Coherence Tomography in Diffuse Unilateral Subacute Neuroretinitis

Filho

Soares

Penha

et al. 2011

Journal of Ophthalmology

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Purpose. To describe the SD-OCT findings in patients with diffuse unilateral subacute neuroretinitis (DUSN) and evaluate CRT and RNFL thickness. Methods. Patients with clinical diagnosis of DUSN who were submitted to SD-OCT were included in the study. Complete ophthalmologic examination and SD-OCT were performed. Cirrus scan strategy protocols used were 200 × 200 macular cube, optic nerve head cube, and HD-5 line raster. Results. Eight patients with DUSN were included. Mean RNFL thickness was 80.25 μm and 104.75 μm for affected and normal eyes, respectively. Late stage had mean RNFL thickness of 74.83 μm compared to 96.5 μm in early stage. Mean CMT was 205.5 μm for affected eyes and 255.13 μm for normal fellow eyes. Conclusion. RNFL and CMT were thinner in DUSN eyes compared to normal eyes. Late-stage disease had more pronounced thinning compared to early-stage patients. This thinning in RNFL and CMT may reflect the low visual acuity in patients with DUSN.

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Retinal nerve fiber layer analysis using GDx® in 49 patients with chronic phase DUSN

Cited by 14 publications

References 17 publications

Intraretinal worm documented by optical coherence tomography in a patient with diffuse unilateral subacute neuroretinitis: case report

Intraretinal worm documented by optical coherence tomography in a patient with diffuse unilateral subacute neuroretinitis: case report

Diffuse unilateral subacute neuroretinitis in a young boy: a case report

Spectral Domain Optical Coherence Tomography in Diffuse Unilateral Subacute Neuroretinitis

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