Retinal microvasculature in the remission period of Behcet’s uveitis

Aksoy, Funda Ebru; Başarır, Berna; Altan, Çiğdem; Paşaoğlu, Işıl; İnal, Aslı; Tunç, Uğur; Ocak, Osman Bulut; Karabulut, Gamze Öztürk

doi:10.1016/j.pdpdt.2019.101646

Cited by 10 publications

(17 citation statements)

References 14 publications

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“… Methodological item for non-randomized studies (No. 1–8) Goker et al 16 Çömez et al 17 Türkcü et al 18 Karalezli et al 19 Emre et al 20 Accorinti et al 28 Koca et al 29 Aksoy et al 30 Eser-Ozturk et al 31 Smid et al 32 Cheng et al 33 Yilmaz et al 34 Pei et al 35 1. Is the Case Definition Adequate?…”

Section: Resultsmentioning

confidence: 99%

Retinal microvasculature features in patients with Behcet’s disease: a systematic review and meta-analysis

Mei

et al. 2022

Sci Rep

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This meta-analysis aimed to analyze retinal microvasculature features in eyes with Behçet’s disease (BD) using optical coherence tomography angiography (OCTA). Electronic databases, including PubMed, Web of Science, Embase, and Cochrane Library, were comprehensively searched for published studies comparing retinal microvasculature characteristics between eyes with BD and controls. Continuous variables were calculated using the mean difference (MD) with 95% confidence interval (CI). Review Manager software (version 5.30) was used to conduct statistical analysis. A total of 13 eligible studies involving 599 eyes with BD and 622 control eyes were included in the meta-analysis. The pooled results showed that the macular whole enface superficial and deep vessel density (VD) values measured by OCTA were significantly lower in eyes with BD than in control eyes (superficial VD: MD = − 3.05, P < 0.00001; deep VD: MD = − 4.05, P = 0.0004). The foveal superficial and deep VD values were also significantly lower in the BD group than in the control group (superficial VD: MD = − 1.50, P = 0.009; deep VD: MD = − 4.25, − = 0.03). Similarly, the analysis revealed a significant reduction in the parafoveal superficial and deep VD in eyes with BD than in control eyes (superficial VD: MD = − 3.68, P < 0.00001; deep VD: MD = − 4.95, P = 0.0007). In addition, the superficial and deep foveal avascular zones (FAZs) were significantly larger in patients with BD than in controls (superficial FAZ: MD = 0.06, P = 0.02; deep FAZ: MD = 0.12, P = 0.03). The present meta-analysis found that macular whole enface VD, foveal VD, and parafoveal VD were lower in eyes with BD, and the FAZ was larger in patients with BD. The findings suggest that OCTA can assist clinicians in diagnosing and monitoring the status of patients with BD.

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Section: Resultsmentioning

confidence: 99%

Retinal microvasculature features in patients with Behcet’s disease: a systematic review and meta-analysis

Mei

et al. 2022

Sci Rep

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“…It is repeatable and ensures almost histological resolution for analysis of VD [25]. It allows for both qualitative and quantitative assessment of the vessels and facilitates the measurement of FAZ [26,27]. OCTA ensures high-resolution scans of both the SCP and DCP and visualization of microvascular alterations, that are not detected via FA [28].…”

Section: Discussionmentioning

confidence: 99%

“…It cannot show leakage, which may be advantageous in some cases as it provides microvascular morphological detail in all segments [29]. It provides a static image and is more prone to artifacts [15,27]. Even though blood cells are the sole moving element in the retina, some non-vascular factors can also cause a signal [15].…”

Section: Discussionmentioning

confidence: 99%

“…They declared that OCTA allowed better visualization of perifoveal vascular changes than FA in Behcet's uveitis [12]. It was reported that deep foveal and parafoveal VDs in OCTA images were signi cantly lower in Behcet's uveitis [27]. Tian et al detected more frequent changes in choriocapillaris and DCP than in the SCP in intermediate uveitis via OCTA [30].…”

Section: Discussionmentioning

confidence: 99%

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Retinal optical coherence tomography angiography findings of acute anterior uveitis

et al. 2021

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Purpose: To evaluate the changes in retinal microvasculature in eyes with anterior uveitis (AU) using optical coherence tomography angiography.Methods: Foveal avascular zone (FAZ) of super cial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) of SCP, DCP, and choriocapillaris, and central macular thickness (CMT) and central foveal thickness (CFT) were calculated from 34 healthy and 41 uveitic eyes. The parameters were compared between the two groups.Results: The deep FAZ was signi cantly lower in the eyes with AU during the attack than after recovery and the control group (p=0.001 and p=0.003, respectively). The VD in deep capillary plexus (DCP) in eyes with AU during the attack was signi cantly higher than the control group (p=0.048). The VD in the foveal sector of DCP in eyes with AU during the attack and after recovery was signi cantly higher than the control group (p=0.001 and p=0.031, respectively). There was no signi cant difference regarding CMT, CFT, VDs of each segment and each sector, and super cial and deep FAZ between eyes with rst uveitis attack and those with recurrent uveitis during the attack and after recovery (p>0.05). Conclusion:The results of this study show that there is a reduction in the FAZ and an increase in the VD of the DCP of the retina during active AU, and these ndings are reversible. Acute AU may affect the macular microvasculature, which is usually temporary, especially in the DCP.

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“…They declared that OCTA allowed better visualization of perifoveal vascular changes than FA in Behcet's uveitis [12]. It was reported that deep foveal and parafoveal VDs in OCTA images were signi cantly lower in Behcet's uveitis [27] . They applied different processing and segmentation settings to each group and found that there were signi cantly lower VD in SCP and DCP of uveitic eyes than those of healthy eyes [26].…”

Section: Discussionmentioning

confidence: 99%

Retinal Optical Coherence Tomography Angiography Findings of Acute Anterior Uveitis

Yalçınkaya

Altan

Başarır

et al. 2021

Preprint

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Purpose: To evaluate the changes in retinal microvasculature in eyes with anterior uveitis (AU) using optical coherence tomography angiography.Methods: Foveal avascular zone (FAZ) of superficial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) of SCP, DCP, and choriocapillaris, and central macular thickness (CMT) and central foveal thickness (CFT) were calculated from 34 healthy and 41 uveitic eyes. The parameters were compared between the two groups.Results: The deep FAZ was significantly lower in the eyes with AU during the attack than after recovery and the control group (p=0.001 and p=0.003, respectively). The VD in deep capillary plexus (DCP) in eyes with AU during the attack was significantly higher than the control group (p=0.048). The VD in the foveal sector of DCP in eyes with AU during the attack and after recovery was significantly higher than the control group (p=0.001 and p=0.031, respectively). There was no significant difference regarding CMT, CFT, VDs of each segment and each sector, and superficial and deep FAZ between eyes with first uveitis attack and those with recurrent uveitis during the attack and after recovery (p>0.05). Conclusion: The results of this study show that there is a reduction in the FAZ and an increase in the VD of the DCP of the retina during active AU, and these findings are reversible. Acute AU may affect the macular microvasculature, which is usually temporary, especially in the DCP.

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Retinal microvasculature in the remission period of Behcet’s uveitis

Cited by 10 publications

References 14 publications

Retinal microvasculature features in patients with Behcet’s disease: a systematic review and meta-analysis

Retinal microvasculature features in patients with Behcet’s disease: a systematic review and meta-analysis

Retinal optical coherence tomography angiography findings of acute anterior uveitis

Retinal Optical Coherence Tomography Angiography Findings of Acute Anterior Uveitis

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