Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI

Choriocapillaris reduction accurately discriminates against early‐onset Alzheimer's disease

“… 28 Given the shared pathophysiology between the retina and the brain, it is proposed that changes in the retinal microvasculature mirror those occurring in the cerebral microvasculature. 32 , 33 , 34 , 35 In line with this, we found a linear correlation between the choriocapillaris and serum Aβ levels, indicating that measuring these retinal changes may have potential as an early screening tool for the preclinical stage of AD. This finding also links the degeneration of fundus microvasculature with Aβ levels during AD progression, a conclusion that aligns with recent studies.…”

“… 32 , 45 Recent research has further suggested that the functionality of retinal microvessels is linked to that of cerebral microcirculation, offering a potential avenue for the early detection of brain microvascular dysfunction. 33 , 34 Choroidal vasculature, which receives its circulation from the ciliary arteries of the ophthalmic artery, compensates for retinal microvascular dropout (especially in the DCP) during hypoxia, conditions of reduced oxygen supply. 46 , 47 Given the close relationship between choriocapillaris and retinal microvasculature, the choriocapillaris could be considered more sensitive to ischemic changes that occur in the retina, such as DCP (Figure S5 in supporting information ).…”

Look into my eyes: What can eye-based measures tell us about the relationship between physical activity and cognitive performance?

“…This assumption is supported by evidence suggesting a relationship between tonic spontaneous eye blink rate and (a) theta power in typically and atypically developing children, 69 (b) N2 amplitudes of the stimulus-locked event-related brain potential under Go- and No-Go-conditions 70 or only a No-Go condition in younger healthy adults, 71 and (c) activity of the angular gyrus in younger healthy adults. 72 Vascular eye-based measures are considered a proxy for the status of the cerebrovascular system, 73 , 74 which is assumed to play, among other factors, a vital role in the positive relationship between physical activity and fitness and measures of cognitive performance. 13 , 34 , 36 , 75 Various approaches can be used to assess the retinal vasculature, such as optical coherence tomography angiography 76 , 77 , 78 or static and dynamic retinal vessel analysis.…”

“…Vascular eye-based measures are considered a proxy for the status of the cerebrovascular system, 73 , 74 which is assumed to play, among other factors, a vital role in the positive relationship between physical activity and fitness and measures of cognitive performance. 13 , 34 , 36 , 75 Various approaches can be used to assess the retinal vasculature, such as optical coherence tomography angiography 76 , 77 , 78 or static and dynamic retinal vessel analysis.…”

Opening a window to the acutely injured brain: Simultaneous retinal and cerebral vascular monitoring in rats

“…Recently, several studies have examined the retina as a proxy for the brain ("window to the brain"), reporting a link between retinal pathologies and neurodegenerative or cerebrovascular diseases (London et al, 2013). Variations in retinal arteriolar microvascular functions and microcirculatory properties of the brain (measured by MRI intravoxel incoherent motion) are linked, potentially enabling early detection of brain microvascular dysfunction (van Dinther et al, 2022). Recently, our group observed the first clinical evidence of retinal vasculature changes after aneurysmal subarachnoid hemorrhage (SAH) (Albanna et al, 2016(Albanna et al, , 2021Conzen et al, 2018).…”