Retinal microvascular changes in patients with familial mediterranean fever: a study based on optical coherence tomography angiography

Erdem, Seyfettin; Karahan, Mine; Ava, Sedat; Dursun, Mehmet; Çevik, Figen Ceylan; Özkul, Emin; Keklíkçí, Uğur; Çevik, Remzi

doi:10.5935/0004-2749.20220038

Cited by 2 publications

(1 citation statement)

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“…OCT angiography findings have been also evaluated in FMF patients with conflicting results. Regarding retinal vascular plexus densities, a decreased vascular density in the deeper capillary plexus in 3x3 mm scans have been detected in FMF patients, with no differences in the remaining parameters analyzed ( 26 ). On the contrary, other authors reported no differences in the macular vessel density (either superficial or in deep capillary plexus) in FMF ( 27 ).…”

Section: Ocular Manifestations In Monogenic Autoinflammatory Diseasesmentioning

confidence: 95%

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Fonollosa,

Carreño,

Vitale

et al. 2024

Front. Ophthalmol.

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Autoinflammatory diseases include disorders with a genetic cause and also complex syndromes associated to polygenic or multifactorial factors. Eye involvement is present in many of them, with different extent and severity. The present review covers ophthalmological lesions in the most prevalent monogenic autoinflammatory diseases, including FMF (familial Mediterranean fever), TRAPS (TNF receptor-associated periodic syndrome), CAPS (cryopyrin-associated periodic syndromes), Blau syndrome, DADA2 (deficiency of adenosine deaminase 2), DITRA (deficiency of the interleukin-36 receptor antagonist), other monogenic disorders, including several ubiquitinopathies, interferonopathies, and the recently described ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome, and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Among polygenic autoinflammatory diseases, ocular manifestations have been reviewed in Behçet’s disease, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome, Still’s disease and autoinflammatory bone diseases, which encompass CRMO (chronic recurrent multifocal osteomyelitis) and SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome.

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Section: Ocular Manifestations In Monogenic Autoinflammatory Diseasesmentioning

confidence: 95%

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Fonollosa,

Carreño,

Vitale

et al. 2024

Front. Ophthalmol.

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Ocular Changes in Children With Familial Mediterranean Fever: The Effect of Subclinical Inflammation?

Sav

Teberik

2022

Preprint

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Purpose: Elevation of acute phase reactants during attack is an important indicator of acute inflammation in Familial Mediterranean Fever (FMF). However, the disease course also involves inflammation in remission period. Subclinical inflammation is a major etiological factor for organ involvement of the disease. The eye is one of the target organs in the course of FMF.Methods: The study included 51 patients with FMF in remission period for at least 3 months and 51 age-matched healthy individuals. Intraocular pressure, axial length, peripapillary retinal nerve fiber layer (RNFL) thickness, central macular thickness, and subfoveal choroidal thickness were assessed for patient and control groups using spectral domain optical coherence tomography (SD-OCT). Patients were grouped according to disease severity scores, and laboratory and ocular findings were compared.Results: Serum amyloid A, C-reactive protein and fibrinogen were higher and temporal inferior RNFL was thinner in the patient group than in the control group (p<0.05). Central macular, submacular choroidal, nasal and temporal thicknesses were lesser in the patient group than in the control group, but there was no statistically significant difference between the groups (p>0.05). On the other hand, a positive correlation was found between proteinuria and axial length in the patient group. Conclusion: Subclinical inflammation is one of the factors responsible for important changes in the eye in FMF. Some changes that occur in the early period can become more prominent with a longer duration of the disease. Follow-up from childhood to adulthood would enable revealing the effects of subclinical inflammation in these patients.

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Retinal microvascular changes in patients with familial mediterranean fever: a study based on optical coherence tomography angiography

Cited by 2 publications

References 4 publications

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Ocular Changes in Children With Familial Mediterranean Fever: The Effect of Subclinical Inflammation?

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