Retinal maculopathy possibly associated with amiodarone medication

Thystrup, Jan D.; Fledelius, Hans C.

doi:10.1111/j.1755-3768.1994.tb07194.x

Cited by 15 publications

(3 citation statements)

References 7 publications

(6 reference statements)

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“…12 Maculopathy has also been reported in amiodraone uses. 13 In addition, amiodarone-associated optic neuropathy (AAON) was reported to occur in 1.76% of amiodarone user in 1987, although its causal relationship remains controversial. 1,[14][15][16] Histopathology Ultrastructural changes of amiodarone-induced effect have been studied in an asymptomatic patient receiving amiodarone.…”

Section: Ocular Changementioning

confidence: 99%

Amiodarone-Associated Optic Neuropathy: Clinical Review

Wang

Cheng

2016

Neuro-Ophthalmology

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Amiodarone, an antiarrhythmic agent, has been associated with visual loss secondary to optic neuropathy. The reported mean duration of amiodarone use before visual loss is about 9 months. Patients receiving amiodarone have a 2-fold increased risk of developing optic neuropathy, especially in males and possibly in patients with longer duration of treatment. Amiodarone-associated optic neuropathy is characterised by an insidious onset, slow progression, bilateral simultaneous visual loss, and protracted disc swelling. After discontinuing amiodarone use, visual acuity and visual field deficits tend to improve or stabilise in most patients, with about 20% of the patients getting worse. ARTICLE HISTORY

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Section: Ocular Changementioning

confidence: 99%

Amiodarone-Associated Optic Neuropathy: Clinical Review

Wang

Cheng

2016

Neuro-Ophthalmology

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“…The changes are reversible after stopping Amiodarone treatment. Amiodarone-related optic neuropathy has been reported after 4 month duration of treatment with unilateral or bilateral visual loss that can progress to blindness [62,63]. Microscopic studies showed the accumulation of lamellar inclusions in the axons of the optic nerve because of drug induced lipidosis [57, 63].…”

Section: The Effects Of Amiodarone On Ocular Tissuementioning

confidence: 99%

A Review on Amiodarone as an Antiarrhythmic Drug

Mehraein¹

2015

Abnormal Heart Rhythms

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Antiarrhythmic drugs are used to suppress abnormal heart rhythms by different mechanisms. Amiodarone as an iodinated benzofuran derivative is a potent antiarrhythmic drug that is being used for the treatment of a wide variety of cardiac arrhythmias. Amiodarone has been reported to cause frequent and potentially serious toxicity. It was estimated that the prevalence of side effects was 15 % in the first year and increased to 50% with long-term therapy. Thyroid, lung, liver, ophthalmologic and neurologic systems can be affected by Amiodarone. Most of the adverse effects of the drug are related to its dosage and duration of administration. Therefore the effectiveness of Amiodarone in long-term treatment of patients with heart arrhythmia is limited because of the development of its adverse side effects.

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“…Amiodarone was also found in tears and severe keratopathy has been reported in a patient wearing soft contact lenses, potentially secondary to trapping of tears [26]. This drug may also lead to anterior subcapsular lens opacities, retinopathy (choroidal neovascularization), and optic neuropathy [20,27,28]. …”

Section: Corneal Manifestationsmentioning

confidence: 99%

Ocular toxicity from systemically administered xenobiotics

Gokulgandhi

Vadlapudi

Mitra

2012

Expert Opinion on Drug Metabolism & Toxicology

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Introduction The eye is considered as the most privileged organ because of the blood–ocular barrier that acts as a barrier to systemically administered xenobiotics. However, there has been a significant increase in the number of reports on systemic drug-induced ocular complications. If such complications are left untreated, then it may cause permanent damage to vision. Hence, knowledge of most recent updates on ever-increasing reports of such toxicities has become imperative to develop better therapy while minimizing toxicities. Areas covered The article is mainly divided into anterior and posterior segment manifestations caused by systemically administered drugs. The anterior segment is further elaborated on corneal complications where as the posterior segment is focused on optic nerve, retinal and vitreous complications. Furthermore, this article includes recent updates on acute and chronic ocular predicaments, in addition to discussing various associated symptoms caused by drugs. Expert opinion Direct correlation of ocular toxicities due to systemic drug therapy is evident from current literature. Therefore, it is necessary to have detailed documentation of these complications to improve understanding and predict toxicities. We made an attempt to ensure that the reader is aware of the characteristic ocular complications, the potential for irreversible drug toxicity and indications for cessation.

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Retinal maculopathy possibly associated with amiodarone medication

Cited by 15 publications

References 7 publications

Amiodarone-Associated Optic Neuropathy: Clinical Review

Amiodarone-Associated Optic Neuropathy: Clinical Review

A Review on Amiodarone as an Antiarrhythmic Drug

Ocular toxicity from systemically administered xenobiotics

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