Retinal Lesions in Subacute Sclerosing Panencephalitis

Fluoroangiographic Picture of the Acute Stage of the Retinal Lesion in Subacute Sclerosing Panencephalitis

“…In our case we could follow up the progression angiographically, first, 4 days after the onset of the initial visual com plaints and, secondly, a week later. Our angiographic findings, in complete accor dance with the histopathological findings of Nelson et al [1970], have shown that the process is primarily a retinitis. The fluoro angiographic examination showed, in the early stage, a localized retinal vascular in volvement, i.e., postcapillary venous occlu sion and hyperpermeability of the veins.…”

Subacute sclerosing panencephalitis: fundus changes and histopathologic correlations

“…Fluorescein angiography indicates variable defects of the pigment epithelium. Preretinal membranes have been described (Raymond et al, 1976) as well as macular holes (Nelson et al, 1970). In our first case the modifications of the macular reflexes were especially striking, As the fundus lesions may precede the neurological symptoms by several months, they are often misdiagnosed.…”

“…Since the original description a large number of such lesions have been reported in the literature (Bec et al, 1979;Brudet-Wickel et al, 1982;Damaske and Diekmann, 1979;Deutman et al, 1976;Font et al, 1973;Gravina et al, 1978;Green and Wirtschafter, 1973;Hiatt et al, 1971;Johnston et al, 1980;Karel et al, 1971;Kloucek and Otradovec, 1969;Kovacq and Vastag, 1978; Landers and Klintworth, 1971; La Piana et al, 1974;Larmande et al, 1972;Meyer et al, 1978;Nelson et al, 1970;Otradovec, 1963Otradovec, , 1969Perdriel et al, 1969;Pette and Doring, 1939;Pulhorn, 1976;Robb and Watters, 1971;Schulz, 1980;Sebestyen and Strenger, 1964;Vannas et al, 1971;Walsh and Hoyt, 1969). The lesion is characterized by edema, retinal folds and sometimes superficial haemorrhages.…”

“…These histopathologic changes also correlate with the ophthalmoscopic impression of rupture of the internal 20 limiting membrane, seen in our first patient. Inclusion bodies may be found in the retina (Kloucek and Otradovec, 1969;Nelson et al, 1970), but are, however, not always present (La Piana et al, 1974). We did not observe them in our case.…”

Eye pathology associated with measles encephalitis in hamsters

“…Papilledema and optic atrophy may also occur. Raised intracranial pressure due to cerebral edema results in papilledema in few cases; in other cases, the papilledema results from inflammation of the orbital portion of the optic nerve [6,11,15]. In hamsters infected with measles, the virus disseminates from the brain to the retina via the blood and causes retinitis that may progress to retinal dysplasia, retinal atrophy, and gliosis [17].…”