Retinal Layer Segmentation in Patients with Multiple Sclerosis Using Spectral Domain Optical Coherence Tomography

García‐Martín, Elena; Polo, Vicente; Larrosa, José M.; Marques, Marcia L.; Herrero, Raquel; Martín, Javier Montero; Ara, J.R.; Fernández, Javier; Júlvez, Luis Pablo

doi:10.1016/j.ophtha.2013.09.035

Cited by 90 publications

(68 citation statements)

References 22 publications

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“…Equally Feng et al [17] demonstrated in Chinese people with MS the thinning of RNFL with SDOCT and they suggested the use of the tomography as a high-resolution, objective, noninvasive, and easily quantifiable in vivo biomarker of MS. OCT is a rapid high-resolution method to obtain morphological and quantitative information that could be important in the management and follow-up of patients with neurodegenerative diseases such as CMI or SM. At least looking at the studies of Garcia-Martin and her research group in Saragoza [18, 19], we obtain a confirmation of what we have already discussed for MS, because the analysis based on the segmentation technologies of the Spectralis OCT (Heidelberg Engineering, Inc., Heidelberg, Germany) showed retinal layer atrophy in patients with MS, especially of the inner layers. They observed also the reduction of the ganglion cell and inner plexiform layer as predictor of greater axonal damage.…”

Section: Discussionsupporting

confidence: 77%

Optical Coherence Tomography in Patients with Chiari I Malformation

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Posarelli

Nasini

et al. 2015

BioMed Research International

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Background/Aims. To evaluate optic nerve head with spectral domain optical coherence tomography (OCT) in patients with Chiari I malformation (CMI) compared to healthy controls. Methods. Cross-sectional study. OCT of the optic nerve head of 22 patients with CMI and 22 healthy controls was quantitatively analyzed. The healthy controls were matched for age and sex with the study population. Mean retinal nerve fiber layer (RNFL) thickness was calculated for both eyes; the mean thickness value was also registered for each quadrant and for each subfield of the four quadrants. Results. CMI patients showed a reduction of the RNFL thickness in both eyes. This reduction was more statistically significant (P < 0.05) for the inferior quadrant in the right eye and in each quadrant than nasal one in the left eye. Conclusion. A distress of the retinal nerve fibers could explain the observed reduction of the RNFL thickness in patients with CMI; in our series the reduction of the RNFL thickness seems lower when CMI is associated with syringomyelia.

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Section: Discussionsupporting

confidence: 77%

Optical Coherence Tomography in Patients with Chiari I Malformation

Figus

Posarelli

Nasini

et al. 2015

BioMed Research International

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“…115 Macular OCT segmentation shows a significant decrease in GCL thickness 113 and volume in eyes of MS patients when compared with disease-free controls. GCL and inner plexiform layer thickness measurements may predict generalised axonal damage in MS more sensitively than RNFL analysis in MS. 116 Histological studies 117 have corroborated OCT findings, identifying involvement of the inner nuclear layer, with significant atrophy noted in 40% of MS eyes, with no atrophy in control eyes. In addition, the degree of retinal atrophy was inversely associated with brain weight, that is, loss of RGCs appears related to loss of cortical volume, potentially reflecting the overall burden of disease.…”

Section: Ms Without Onmentioning

confidence: 77%

How strong is the relationship between glaucoma, the retinal nerve fibre layer, and neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis?

Jones-Odeh

Hammond

2015

Eye

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Glaucoma is a neurodegenerative disorder with established relationships with ocular structures such as the retinal nerve fibre layer (RNFL) and the ganglion cell layer (GCL). Ocular imaging techniques such as optical coherence tomography (OCT) allow for quantitative measurement of these structures. OCT has been used in the monitoring of glaucoma, as well as investigating other neurodegenerative conditions such as Alzheimer's disease (AD) and multiple sclerosis (MS). In this review, we highlight the association between these disorders and ocular structures (RNFL and GCL), examining their usefulness as biomarkers of neurodegeneration. The average RNFL thickness loss in patients with AD is 11 μm, and 7 μm in MS patients. Most of the studies investigating these changes are cross-sectional. Further longitudinal studies are required to assess sensitivity and specificity of these potential ocular biomarkers to neurodegenerative disease progression. Eye (2015Eye ( ) 29, 1270Eye ( -1284 doi:10.1038/eye.2015; published online 4 September 2015 IntroductionGlaucoma is a neurodegenerative optic neuropathy manifesting with progressive retinal ganglion cell (RGC) and axonal loss, which can result in visual field defects and blindness because of permanent cellular and neuronal damage. Subjective clinical examination of the optic nerve head (ONH) allows for assessment and monitoring of the structural changes associated with glaucoma. However, objective detection of defects in the peripapillary retinal nerve fibre layer (RNFL) by ophthalmoscopy is difficult. The relationship between glaucoma progression and the structural changes observed at the ONH, RGC layer, and RNFL in glaucoma is well established. [1][2][3][4] Early diagnosis and treatment of glaucoma is vital to maintain visual field, as loss of RGCs is irreversible, 5 and even before any detectable visual field defects, there is a substantial loss of RGCs. Morphological abnormalities can develop 3-5 years before any functional loss is detected. 6 Since the introduction of ocular imaging techniques such as optical coherence tomography (OCT), peripapillary RNFL thickness measurements have been used for the detection and monitoring of glaucoma. 7,8 However, the use of OCT has extended beyond RNFL measurements for glaucoma, and has also been used in the investigation of other neurodegenerative disorders such as Alzheimer's disease (AD) 9-11 and multiple sclerosis (MS). [12][13][14] In addition, given the similarities of brain and retinal foetal angiogenesis, 15,16 retinal microvasculature has also been investigated as a biomarker of changes in cerebral vasculature and cognitive decline. [17][18][19] In this review, we examine the relationships between glaucoma, neurodegenerative disease, and cognitive impairment, and the use of RNFL thickness and RGC loss as potential ocular biomarkers for neurodegenerative disorders such as AD and MS. We review the strength of associations between RNFL and RGC and Eye (2015Eye ( ) 29, 1270Eye ( -1284Eye ( © 2015 Macmillan Publis...

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“…Optical coherence tomography (OCT) is a useful tool that can be used to evaluate the differences between NMO- ON and MS-ON [38,39]. OCT showed more severe retinal damage after ON episodes in NMO compared to relapsingremitting MS [40,41].…”

Section: Discussionmentioning

confidence: 99%

Features of anti-aquaporin 4 antibody-seropositive Chinese patients with neuromyelitis optica spectrum optic neuritis

Wang

et al. 2015

J Neurol

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The detection of anti-aquaporin-4 autoantibody (AQP-4 Ab) is crucial to detect patients who will develop neuromyelitis optica (NMO); however, there are few studies on the AQP-4 Ab serostatus of patients with neuromyelitis optica spectrum ON. We analyzed the clinical and paraclinical features of neuromyelitis optica spectrum ON patients in China according to the patients' AQP4-Ab serostatus. 125 patients with recurrent and bilateral ON with simultaneous attacks were divided into AQP-4 Ab-seropositive and -seronegative groups. Demographic, clinical, serum autoantibody data, connective tissue disorders (CTDs), visual performance were compared. A Visual Acuity (VA) of less than 0.1 during acute ON attacks occurred more frequently in the seropositive group (p = 0.023); however, there was not a significant difference between groups on VA recovery after the first attack. The seropositive group experienced the worst outcome during the last attack (p = 0.017). Other co-existing autoimmunity antibodies (p < 0.001) and CTDs (p < 0.001) were more prevalent in seropositive patients. There were no significant differences on VA recovery and RNFLT combined with other autoantibodies or CTDs. The two groups did not differ significantly with regard to time to relapse, annualized relapse rates, time of diagnosis NMO, or RNFL. There were no significant differences on VA recovery and RNFLT combined with other autoantibodies or CTDs. RNFLT was thinner in NMO seropositive patients. Although AQP-4 Ab expression predicted poor visual outcome, positive patients were usually associated with mild symptoms at first onset. Anti-SSA/SSB antibody or Sjögren syndrome may be associated with AQP-4 Ab in neuromyelitis optica spectrum ON.

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Retinal Layer Segmentation in Patients with Multiple Sclerosis Using Spectral Domain Optical Coherence Tomography

Cited by 90 publications

References 22 publications

Optical Coherence Tomography in Patients with Chiari I Malformation

Optical Coherence Tomography in Patients with Chiari I Malformation

How strong is the relationship between glaucoma, the retinal nerve fibre layer, and neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis?

Features of anti-aquaporin 4 antibody-seropositive Chinese patients with neuromyelitis optica spectrum optic neuritis

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