Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study

Bannai, Deepthi; Lizano, Paulo; Kasetty, Megan; Lutz, Olivia; Zeng, Victor; Sarvode, Suraj; Kim, Leo A.; Hill, S. Kristian; Tamminga, Carol A.; Clementz, Brett A.; Gershon, Elliot S.; Pearlson, Godfrey D.; Miller, John B.; Keshavan, Matcheri S.

doi:10.1016/j.pscychresns.2020.111061

Cited by 30 publications

(25 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings add to the emerging literature suggesting the utility of retinal changes as a proxy measure for brain structural changes. Our finding of the association of retinal venular diameter with global cortical thickness is comparable to the previous study which reported a thinner retina layer to be associated with smaller brain volume (Bannai et al, 2020). In addition to the global brain measures, we also examined the individual regional measures.…”

Section: Discussionsupporting

confidence: 86%

“…We did not exclude people with obesity or measure the body mass index of the patients. However, considering the absence of relation with retinal vascular measures in a recent study and our previous study of which the current study subjects were drawn, it is not likely to be the sole contributor to the findings (Appaji, Abhishek et al, 2019b;Bannai et al, 2020). Nonetheless, future studies need to examine the effect of obesity on the relation between brain measure and retinal vascular caliber in schizophrenia.…”

Section: Discussionmentioning

confidence: 75%

“…Two studies have examined the relationship between the retinal nerve fiber layer and structural brain parameters using magnetic resonance imaging in schizophrenia patients. While one study reported an association between the outer nuclear layer thinning and smaller total brain and white matter volumes (Bannai et al, 2020), the other study reported co-impairments in the retinal nerve fiber layer and primary visual cortex but no relation between the two (Zhuo et al, 2020). To date, no study has examined the relationship between retinal vascular caliber and brain structural alterations in schizophrenia patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between retinal vascular caliber and brain structure in schizophrenia

Korann

Appaji²,

Jacob

et al. 2021

Asian Journal of Psychiatry

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between retinal vascular caliber and brain structure in schizophrenia

Korann

Appaji²,

Jacob

et al. 2021

Asian Journal of Psychiatry

View full text Add to dashboard Cite

“…Few OCT studies have evaluated the outer retina in SSD. Samani et al 8 reported thinning of the outer nuclear layer and inner segments of the photoreceptors, whereas Bannai et al 13 suggested thickening of the outer plexiform layer. We evaluated the photoreceptor complex, which includes retinal thickness spanning from the outer nuclear layer to the retinal pigment epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies in schizophrenia reported significantly lower retinal nerve fiber layer (RNFL) thickness in patients as compared to controls. [4][5][6][7][8][9][10][11][12][13][14][15] Two meta analyses showed significant thinning in all RNFL quadrants except the superior quadrant. 14,15 Notably, however, results of individual studies have been widely variable, and most prior reports do not control for relevant ocular parameters including intraocular pressure, axial length, and anterior chamber depth, which could be associated with retinal thickness measurements.…”

Section: Introductionmentioning

confidence: 99%

Neuroretinal Biomarkers for Schizophrenia Spectrum Disorders

Asanad

O’Neill

Addis

et al. 2021

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose We evaluated the patient-control differences and predictive value of the retina as potential biomarkers for schizophrenia. Methods The institutional study included both eyes of 58 schizophrenia spectrum disorder (SSD) patients (age 37.2 ± 12.3 years) and 35 controls (age 41.1 ± 15.2 years). Retinal nerve fiber layer (RNFL), ganglion cell–inner plexiform layer, outer retinal photoreceptor complex, and total macula thicknesses were measured by optical coherence tomography (OCT). Anterior segment parameters including central corneal thickness, anterior chamber depth, and axial length were measured to rule out confounds on the retinal measures. Results The peripapillary RNFL was overall significantly thinner in SSD relative to controls ( F = 3.97, P = 0.049), most pronounced in the temporal (5.2 µm difference, F = 6.95, P = 0.010) and inferior quadrants (12.1 µm difference, F = 7.32, P = 0.009). There were no significant group differences in thickness for the macular RNFL, ganglion, or photoreceptor cell related measures ( P > 0.05). Peripapillary RNFL, central macula, and outer photoreceptor complex thicknesses were together able to classify SSD patients with 80% sensitivity and 71% specificity; area under the curve = 0.82 (95% confidence interval, 0.75–0.88). Conclusions SSD patients exhibited significant RNFL thinning relative to controls. Notably, retinal thickness measures including both peripapillary and macular data exhibited improved diagnostic accuracy for SSD as compared to these regions alone. Translational Relevance This is the first study to evaluate the predictive value of both the inner and outer retina in SSD. OCT retinal thickness measures including peripapillary data in conjunction with macular data may provide an informative, noninvasive in vivo ocular biomarker for schizophrenia.

show abstract

Optical coherence tomography reveals retinal thinning in schizophrenia spectrum disorders

Boudriot

Schworm

Slapakova

et al. 2022

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Background Schizophrenia spectrum disorders (SSDs) are presumed to be associated with retinal thinning. However, evidence is lacking as to whether these retinal alterations reflect a disease-specific process or are rather a consequence of comorbid diseases or concomitant microvascular impairment. Methods The study included 126 eyes of 65 patients with SSDs and 143 eyes of 72 healthy controls. We examined macula and optic disc measures by optical coherence tomography (OCT) and OCT angiography (OCT-A). Additive mixed models were used to assess the impact of SSDs on retinal thickness and perfusion and to explore the association of retinal and clinical disease-related parameters by controlling for several ocular and systemic covariates (age, sex, spherical equivalent, intraocular pressure, body mass index, diabetes, hypertension, smoking status, and OCT signal strength). Results OCT revealed significantly lower parafoveal macular, macular ganglion cell–inner plexiform layer (GCIPL), and macular retinal nerve fiber layer (RNFL) thickness and thinner mean and superior peripapillary RNFL in SSDs. In contrast, the applied OCT-A investigations, which included macular and peripapillary perfusion density, macular vessel density, and size of the foveal avascular zone, did not reveal any significant between-group differences. Finally, a longer duration of illness and higher chlorpromazine equivalent doses were associated with lower parafoveal macular and macular RNFL thickness. Conclusions This study strengthens the evidence for disease-related retinal thinning in SSDs.

show abstract

Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study

Cited by 30 publications

References 51 publications

Association between retinal vascular caliber and brain structure in schizophrenia

Association between retinal vascular caliber and brain structure in schizophrenia

Neuroretinal Biomarkers for Schizophrenia Spectrum Disorders

Optical coherence tomography reveals retinal thinning in schizophrenia spectrum disorders

Contact Info

Product

Resources

About