Retinal involvement in acute thrombotic thrombocytopenic purpura: a case report

Abstract

Background Thrombotic thrombocytopenic purpura (TTP) is a life-threatening hematological condition associated with deficiency in ADAMTS13. Ocular manifestations associated with TTP are uncommon. Case presentation Here we report a case where a 44 year old female patient with a history of symptomatic anemia and cotton wool appearance in retina during ophthalmological examination and subsequently, she was diagnosed to have TTP. The proper management with Therapeutic Plasma Exchange (TPE) and IV methylprednisolone improved the condition of the patient markedly. Conclusion It concludes that even though the presence of cotton wool appearance in retina is a nonspecific sign it needs to be properly evaluated as there can be underlying serious illnesses as in our patient. Cotton wool spots can be an early sign of underlying retinal compromise and it should be identified early.

First report of a de novo iTTP episode associated with an mRNA‐based anti‐COVID‐19 vaccination

“…On referral, apart from diffuse ecchymosis, physical examination was normal. However, ophthalmological examination showed signs of central serous chorioretinopathy, caused by platelet‐rich microthrombus formation in the choroid vasculature, as an ocular manifestation related to TTP 8 . Initial blood results were also indicative of TTP, with a PLASMIC score of six .…”

Thrombocytopenia and Retina

“…Trombositopenik hastalarda gözlenen arka segment patolojileri retinal kanama, subretinal kanama, vitreus kanaması, koroidal kanama, retina iskemisi, retina damar oklüzyonu, retina neovaskülarizasyonu, proliferatif retinopati, seröz retina dekolmanı, traksiyonel retina dekolmanı, papilödem ve Purtscher benzeri retinopati olarak sıralanabilir. [12][13][14][15][16][17] Bu patolojiler arasında en sık gözleneni ise retina kanamalarıdır. [1] Retina patolojileri sadece trombositopeni etkisiyle değil, ilgili hastalıklara eşlik eden tromboz nedeniyle de ortaya çıkmaktadır.…”

“…[18,19] TTP' de retinal kanama, pamuksu lekeler ve seröz dekolmanın haricinde papilödem, retinada yeni damar oluşumu ve traksiyonel retina dekolmanı (TRD) gelişebilmektedir. [12,17] TTP' de kombine santral retinal arter ve ven oküzyonu gelişen ve kötü prognozlu vakalar da bildirilmiştir. [21] Retina bulgularının hafif seyrettiği olgular, klasik trombositopeni tedavisini takiben sıklıkla düzelirler.…”