Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis

Knier, Benjamin; Schmidt, Paul; Aly, Lilian; Buck, Dorothea; Berthele, Achim; Mühlau, Mark; Zimmer, Claus; Hemmer, Bernhard; Korn, Thomas

doi:10.1093/brain/aww219

Cited by 93 publications

(111 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conversely, longitudinal data on INL thickness are available. INL volume changes are thought to reflect inflammatory disease activity . In our study, no association was found between INL thickness and VH changes.…”

Section: Discussioncontrasting

confidence: 80%

Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis

Coric

Ometto

Montesano

et al. 2019

Euro J of Neurology

View full text Add to dashboard Cite

Background and purposeThe occurrence of intermediate uveitis, which is characterized by the presence of vitreous haze (VH), in patients with multiple sclerosis (MS) may be a sign of coexistent inflammatory central nervous system (CNS) disease activity. Using an automated algorithm to quantify VH on optical coherence tomography (OCT) scans, the aim was to investigate whether VH in MS patients is associated with signs of inflammatory CNS disease activity.MethodsVitreous haze was quantified on OCT macular volume scans of 290 MS patients and 85 healthy controls (HCs). The relationship between VH and clinical, retinal OCT and magnetic resonance imaging parameters of inflammatory disease activity was investigated using generalized estimating equations.ResultsMean VH scores did not differ between patients and HCs (P = 0.629). Six patients (2.1%) showed values higher than the highest of the controls by HCs. VH scores did not differ between the different disease types or between eyes with and without a history of optic neuritis (P = 0.132). VH was not associated with inner nuclear layer volume on OCT (P = 0.233), cerebral T2 lesion load on magnetic resonance imaging (P = 0.416) or the development of new relapses (P = 0.205).ConclusionIn this study, OCT‐based automated VH estimation did not detect increased vitreous inflammation in MS patients compared to HCs and did not find an association with CNS inflammatory burden.

show abstract

Section: Discussioncontrasting

confidence: 80%

Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis

Coric

Ometto

Montesano

et al. 2019

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…Data were from 2367 eyes from 18 studies In MSNON eyes, the ONPL was minimally thinner compared to con-17 trol eyes ( Figure 5E, p=0.14). Data were based on 954 eyes from five studies 20,37,53,54,57 .…”

Section: Resultsmentioning

confidence: 99%

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis

Imsvisual

2017

The Lancet Neurology

Self Cite

401

387

View full text Add to dashboard Cite

show abstract

“…This is in contrast to OCT derived parameters, where optic neuritis causes additional damage and thus frequently interferes with the use of OCT parameters as surrogates for disease progression 24 . Recent applications of OCT as disease progression biomarker have therefore focused on eyes without previous optic neuritis 25,26 . The high frequency of optic neuritis in MS patients (confirmed in our random sample) thus limits these novel OCT applications.…”

Section: Discussionmentioning

confidence: 99%

Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density

et al. 2016

View full text Add to dashboard Cite

Background Many studies in multiple sclerosis (MS) have investigated the retina. Little however is known about the effect of MS on the cornea, which is innervated by the trigeminal nerve. It is the site of neural-immune interaction with local dendritic cells reacting in response- to environmental stimuli. Objective This study aims to investigate the effect of MS on- corneal nerve fibres and dendritic cells in the subbasal nerve plexus using in vivo confocal microscopy (IVCM). Methods We measured the corneal nerve fibre and dendritic cell density in 26 MS patients and matched healthy controls using a Heidelberg Retina Tomograph with Cornea Module. Disease severity was assessed with the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale, visual acuity and retinal optical coherence tomography. Results We observed significant reduction in total corneal nerve fibre density in MS patients compared to controls. Dendritic cell density was similar in both groups. Reduced total nerve fibre density was associated with worse clinical severity, but not with previous clinical trigeminal symptoms, retinal neuroaxonal damage, visual acuity, or disease duration. Conclusion Corneal nerve fibre density is a promising new imaging marker for the assessment of disease severity in MS and should be investigated further.

show abstract

Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis

Cited by 93 publications

References 34 publications

Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis

Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis

Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density

Contact Info

Product

Resources

About