Retinal immunopathology in horses with uveitis

Kalsow, Carolyn M.; Dwyer, Ann E.

doi:10.1076/ocii.6.4.239.4026

Cited by 45 publications

(32 citation statements)

References 8 publications

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“…Retinal damage in horses with uveitis is related to the presence of B lymphocytes in the retina (318). Antiplatelet antibodies have been demonstrated in human leptospirosis (144,339).…”

Section: Immune Mechanismsmentioning

confidence: 99%

“…Equine recurrent uveitis appears to be an autoimmune disease (358,443), and Faine (211) suggested that late-onset uveitis in humans may result from an autoimmune reaction to subsequent exposure. Immune involvement in retinal pathology has been demonstrated in horses with spontaneous uveitis (318). Leptospires have been isolated from the human eye (16), and more VOL.…”

Section: Chronic or Latent Infectionmentioning

confidence: 99%

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Leptospirosis

2001

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Leptospirosis is a worldwide zoonotic infection with a much greater incidence in tropical regions and has now been identified as one of the emerging infectious diseases. The epidemiology of leptospirosis has been modified by changes in animal husbandry, climate, and human behavior. Resurgent interest in leptospirosis has resulted from large outbreaks that have received significant publicity. The development of simpler, rapid assays for diagnosis has been based largely on the recognition that early initiation of antibiotic therapy is important in acute disease but also on the need for assays which can be used more widely. In this review, the complex taxonomy of leptospires, previously based on serology and recently modified by a genotypic classification, is discussed, and the clinical and epidemiological value of molecular diagnosis and typing is also evaluated

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“…Retinal damage in horses with uveitis is related to the presence of B lymphocytes in the retina (318). Antiplatelet antibodies have been demonstrated in human leptospirosis (144,339).…”

Section: Immune Mechanismsmentioning

confidence: 99%

Section: Chronic or Latent Infectionmentioning

confidence: 99%

Leptospirosis

2001

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“…The worldwide distribution of this potentially fatal zoonotic infection and its association with autoimmune disease (12,23,35) provide the impetus to develop an effective and safe vaccine. Prevention of leptospirosis in dogs is accomplished to some extent by inoculation with bacterins that contain the most commonly encountered serovars.…”

mentioning

confidence: 99%

Immunoprotection of Recombinant Leptospiral Immunoglobulin-Like Protein A against Leptospira interrogans Serovar Pomona Infection

et al. 2006

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We previously reported the cloning and characterization of leptospiral immunoglobulin-like proteins LigA and LigB of Leptospira interrogans. LigA and LigB are conserved at the amino-terminal region but are variable at the carboxyl-terminal region. Here, we evaluate the potential of recombinant LigA (rLigA) as a vaccine candidate against infection by L. interrogans serovar Pomona in a hamster model. rLigA was truncated into conserved (rLigAcon) and variable (rLigAvar) regions and expressed in Escherichia coli as a fusion protein with glutathione-S-transferase (rLigA). Golden Syrian hamsters were immunized at 3 and 6 weeks of age with rLigA (rLigAcon and rLigAvar) with aluminum hydroxide as an adjuvant. Hamsters given recombinant glutathione-S-transferase (rGST)-adjuvant and phosphate-buffered saline-adjuvant served as nonvaccinated controls. Three weeks after the last vaccination, all animals were challenged intraperitoneally with 10 8 L. interrogans serovar Pomona bacteria (NVSL 1427-35-093002). All hamsters immunized with recombinant LigA survived after challenge and had no significant histopathological changes. In contrast, nonimmunized and rGSTimmunized hamsters were subjected to lethal doses, and the hamsters that survived showed severe tubulointerstitial nephritis. All vaccinated animals showed a rise in antibody titers against rLigA. Results from this study indicate that rLigA is a potential vaccine candidate against L. interrogans serovar Pomona infection.

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“…Symptoms of infection vary from subclinical to potentially fatal with multiorgan involvement (30,38,50). Immune-based uveitis leading to blindness (12,26,40,51) is a devastating sequela in humans and horses. Survival of the organism in water and persistent urinary shedding by wildlife, rodents, and livestock complicate control of the disease (30,50).…”

mentioning

confidence: 99%