Ophthalmology is a core medical field that is of interest to many. Retinal examination is a commonly performed diagnostic procedure that can be used to inspect the interior of the eye and screen for any pathological symptoms. Although various types of eye examinations exist, there are many cases where it is difficult to identify the retinal condition of the patient accurately because the test image resolution is very low because of the utilization of simple methods. In this paper, we propose an image synthetic approach that reconstructs the vessel image based on past retinal image data using the multilayer perceptron concept with artificial neural networks. The approach proposed in this study can convert vessel images to vessel-centered images with clearer identification, even for low-resolution retinal images. To verify the proposed approach, we determined whether high-resolution vessel images could be extracted from low-resolution images through a statistical analysis using high- and low-resolution images extracted from the same patient.