Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling

Behrens, Christian; Yadav, Shubhash Chandra; Korympidou, Maria M.; Zhang, Yue; Haverkamp, Silke; Irsen, Stephan; Schaedler, Anna; Lu, Xiaoyu; Lause, Jan; St-Pierre, François; Franke, Katrin; Vlasits, Anna; Dedek, Karin; Smith, Robert G.; Euler, Thomas; Berens, Philipp; Schubert, Timm

doi:10.1016/j.cub.2021.11.055

Cited by 17 publications

(25 citation statements)

References 77 publications

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“…Implications for the adoption of GEVIs for in vivo voltage recordings In this study, we report on JEDI-2P, a new voltage indicator that addresses a critical need in neuroscience: the noninvasive recording of rapid voltage transients for extended durations and in deep cortical layers. We evaluated JEDI-2P for reporting voltage dynamics in different cell types, subcellular locations, and animal models (also see Behrens et al, 2022). We also demonstrated that JEDI-2P could record voltage responses using distinct 2PM microscopy methods.…”

Section: Discussionmentioning

confidence: 95%

Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

Liu¹,

Lu²,

Villette³

et al. 2022

Cell

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Section: Discussionmentioning

confidence: 95%

Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

Liu¹,

Lu²,

Villette³

et al. 2022

Cell

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“…UV-On) could simultaneously receive sign-preserving inputs from H1 and/or H2 HCs, which themselves carry a sign-preserving long-wavelength biased signal 7 . In zebrafish, the presence of direct inputs from HCs to BCs has not been observed; however, the concept is tentatively supported by the anatomical presence HC-BC contacts in mice 52 . Third, zebrafish might have ACs that use fast neurotransmitters other than GABA and/or glycine, which presumably continue to function throughout our pharmacological interventions.…”

Section: Discussionmentioning

confidence: 99%

Amacrine cells differentially balance zebrafish colour circuits in the central and peripheral retina

Wang

Roberts

Yoshimatsu

et al. 2022

Preprint

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In vertebrate vision, the feature extracting circuits of the inner retina are driven by heavily pre-processed photoreceptor signals. For example, in larval zebrafish, outer retinal circuits serve to split "colour" from "greyscale" information across their four ancestral cone–photoreceptor types. How then can the inner retina simultaneously preserve such incoming spectral information despite the need to combine cone-signals to shape new greyscale functions? To address this question, we imaged light-driven signals from the axon terminals of retinal bipolar cells in the presence and pharmacological absence of inhibition from amacrine cells. Surprisingly, this manipulation had no net effect on the inner retinal representation of colour-opponency, despite profound impacts on all tested greyscale functions such as the gain and kinetics of bipolar cell light responses. This "dynamic balance" was achieved by amacrine cells driving opponency in some bipolar cells, while at the same time suppressing pre-existing opponency in others, such that the net change across the network was essentially zero. To do so, amacrine cells near-exclusively leveraged the On-channel, and correspondingly, a direct in vivo survey of amacrine cell functions revealed that all their colour-opponent responses were located in the On-layer. In contrast, Off-stratifying amacrine cells were largely achromatic. We conclude that complex interactions within the inner retina that underlie greyscale visual processing tasks are intricately balanced via the On-channel to not notably alter the pre-existing population representation of colour information.

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“…BCs that express ionotropic glutamate receptors (BCs: 1(ab), 2, 3(a,b), 4) are responsible for forming the OFF signaling routes [ 11 , 12 ], whereas those that utilize metabotropic glutamate receptors (5(a–d), 6, 7, 8/9) are responsible for conveying ON signals [ 11 ]. The first synaptic layer of the retina is also equipped with HCs that express inhibitory GABA as a transmitter and signal laterally, thereby providing feedback and feedforward inhibition to PRs and BCs, respectively [ 13 ]. This inhibition serves mainly as a spatial filter and thus forms the basis for an inhibitory surround receptive field of downstream retinal neurons and thus contrast detection for vision [ 14 ].…”

Section: The Wiring Of the Mammalian Retinamentioning

confidence: 99%

“…HCs are GABA-expressing inhibitory cells in the outer retina. They receive glutamatergic excitation from photoreceptors and provide feedback inhibition to photoreceptors and feedforward inhibition to BCs ( Figure 4 ) [ 13 ]. It has been shown that the inhibitory feedback is established through ephaptic mechanisms whose morphological substrate is provided by pore-forming hemichannels [ 59 , 60 , 61 ].…”

Section: Circuit Elements That Contribute To Response Transiencementioning

confidence: 99%

Transience of the Retinal Output Is Determined by a Great Variety of Circuit Elements

Ganczer

Szarka

Balogh

et al. 2022

Cells

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Retinal ganglion cells (RGCs) encrypt stimulus features of the visual scene in action potentials and convey them toward higher visual centers in the brain. Although there are many visual features to encode, our recent understanding is that the ~46 different functional subtypes of RGCs in the retina share this task. In this scheme, each RGC subtype establishes a separate, parallel signaling route for a specific visual feature (e.g., contrast, the direction of motion, luminosity), through which information is conveyed. The efficiency of encoding depends on several factors, including signal strength, adaptational levels, and the actual efficacy of the underlying retinal microcircuits. Upon collecting inputs across their respective receptive field, RGCs perform further analysis (e.g., summation, subtraction, weighting) before they generate the final output spike train, which itself is characterized by multiple different features, such as the number of spikes, the inter-spike intervals, response delay, and the rundown time (transience) of the response. These specific kinetic features are essential for target postsynaptic neurons in the brain in order to effectively decode and interpret signals, thereby forming visual perception. We review recent knowledge regarding circuit elements of the mammalian retina that participate in shaping RGC response transience for optimal visual signaling.

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Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling

Cited by 17 publications

References 77 publications

Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

Amacrine cells differentially balance zebrafish colour circuits in the central and peripheral retina

Transience of the Retinal Output Is Determined by a Great Variety of Circuit Elements

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