Retinal ganglion cell dendrites undergo a visual activity‐dependent redistribution after eye opening

Xu, Hong; Tian, Na

doi:10.1002/cne.21379

Cited by 61 publications

(102 citation statements)

References 48 publications

(120 reference statements)

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“…We observed immunolabeling similar to that previously observed in the mouse retina using the same antibody (Quraishi et al, 2007;Xu and Tian, 2007;Puthussery et al, 2010;Hilgen et al, 2011).…”

Section: Anti-calretininsupporting

confidence: 86%

Requirement for the paired‐like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation

Shi¹,

Jervis²,

Nickerson³

et al. 2011

J of Comparative Neurology

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Retinal bipolar cells make up a class of at least 11 distinct interneurons that have been classified through morphological and molecular approaches. Previous work has shown that the paired-like homeodomain transcription factor Vsx1 is essential for the proper development of a subset of these interneurons. In Vsx1-null mice, bipolar cells are properly specified but exhibit terminal differentiation defects characterized by reduced expression of OFF bipolar cell markers and defects in OFF visual signaling. Here, we further examined the role of Vsx1 in OFF bipolar cells using recently identified cell-type-specific markers. In contrast to its previously characterized expression in type 2 OFF bipolar cells, Vsx1 expression was not detected in type 3 OFF bipolar cells, by either immunohistological or transgenic reporter labeling approaches. This observation was unexpected given previous findings that Cabp5 immunolabeling of type 3 bipolar cell axon terminals is reduced in Vsx1-null mice. However, we observed reduced levels of the type 3a bipolar cell marker hyperpolarization-activated and cyclic nucleotide-gated channel 4 (HCN4) in Vsx1-null mice, which is consistent with a requirement for Vsx1 in type 3 bipolar cell differentiation. In contrast, expression of the type 3b bipolar cell marker regulatory subunit RII-beta of protein kinase A was unchanged. Despite the absence of Vsx1 in mature type 3 bipolar cells, colabeling of Vsx1 and HCN4 was observed at postnatal stages. These findings reveal a role for Vsx1 in type 3a bipolar cells and suggest that Vsx1 function is required transiently in this cell type during the postnatal period.

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Section: Anti-calretininsupporting

confidence: 86%

Requirement for the paired‐like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation

Shi¹,

Jervis²,

Nickerson³

et al. 2011

J of Comparative Neurology

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“…A recent study combined the two-photon calcium imaging with the serial-section electron microscopy and suggested about 10% DSGCs in the mouse retina (Briggman et al 2011). One group of ON-OFF DSGCs labeled by 1,1=-dioctadecyl-3,3,3=,3=-tetramethylindocarbocyanine perchlorate (DiI) is counted for 16% of total RGCs (Sun et al 2002), while another study suggested 21% (Xu and Tian 2007). Huberman and colleagues (2009) suggested the total ON-OFF DSGCs is about 20 -36%.…”

Section: Discussionmentioning

confidence: 99%

“…3C and Table 1), which falls into the range in the above study. ON DSGCs are counted for 5% of the total RGCs in the rabbit retina (Oyster 1968) and 3-7% in the mouse retina (Sun et al 2002;Xu and Tian 2007). Here we show ON DSGCs was ϳ10% at P30 ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Subtype-dependent postnatal development of direction- and orientation-selective retinal ganglion cells in mice

Chen

Liu

Tian

2014

Journal of Neurophysiology

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Chen H, Liu X, Tian N. Subtype-dependent postnatal development of direction-and orientation-selective retinal ganglion cells in mice. J Neurophysiol 112: 2092J Neurophysiol 112: -2101J Neurophysiol 112: , 2014. First published August 6, 2014; doi:10.1152/jn.00320.2014.-The direction-selective ganglion cells (DSGCs) and orientation-selective ganglion cells (OSGCs) encode the directional and the orientational information of a moving object, respectively. It is unclear how DSGCs and OSGCs mature in the mouse retina during postnatal development. Here we investigated the development of DSGCs and OSGCs after eye-opening. We show that 1) DSGCs and OSGCs are present at postnatal day 12 (P12), just before eye-opening; 2) the fractions of both DSGCs and OSGCs increase from P12 to P30; 3) the development of DSGCs and OSGCs is subtype dependent; and 4) direction and orientation selectivity are two separate features of retinal ganglion cells (RGCs) in the mouse retina. We classified RGCs into different functional subtypes based on their light response properties. Compared with P12, the direction and orientation selectivity of ON-OFF RGCs but not ON RGCs became stronger at P30. The tuning width of DSGCs for both ON and ON-OFF subtypes decreased with age. For OSGCs, we divided them into non-direction-selective (non-DS) OSGCs and direction-selective OSGCs (DS&OSGCs). For DS&OSGCs, we found that there was no correlation between the direction and orientation selectivity, and that the tuning width of both ON and ON-OFF subtypes remained unchanged with age. For non-DS OSGCs, the tuning width of ON but not ON-OFF subtype decreased with development. These findings provide a foundation to reveal the molecular and synaptic mechanisms underlying the development of the direction and orientation selectivity in the retina.retinal ganglion cell; multielectrode array; direction-selective ganglion cell; orientation-selective ganglion cell

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“…If the rate of RGC dendrite extension is different from interstitial stretch, rewiring is required to maintain the neural circuitries. Many studies in the literature examined the developmental changes of the RGCs including transient features, dendritic remodeling, stratification, and interaction in many species (Perry and Linden, 1982;Leventhal et al, 1988;Ramoa et al, 1988;Yamasaki and Ramoa, 1993;Weber et al, 1998;Wong et al, 2000;Wong and Wong, 2001;Yamagata et al, 2002;Lin et al, 2004;Mumm et al, 2005;Xu and Tian, 2007;Tian, 2008;Yamagata and Sanes, 2008). To our knowledge, the only attempt in the literature to evaluate differential change of the ganglion cell density is in the rabbit retina using Müller cells as a reference (Reichenbach et al, 1993;Deich et al, 1994).…”

Section: Introductionmentioning

confidence: 94%

Changing dendritic field size of mouse retinal ganglion cells in early postnatal development

Ren

Liang

Diao

et al. 2010

Developmental Neurobiology

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During early postnatal development, dendrites of retinal ganglion cells (RGCs) extend and branch in the inner plexiform layer to establish the adult level of stratification, pattern of branching, and coverage. Many studies have described the branching patterns, transient features, and regulatory factors of stratification of the RGCs. The rate of RGC dendritic field (DF) expansion relative to the growing retina has not been systematically investigated. In this study, we used two methods to examine the relative expansion of RGC DFs. First, we measured the size of RGC DFs and the diameters of the eyeballs at several postnatal stages. We compared the measurements with the RGC DF sizes calculated from difference of the eyeball sizes based on a linear expansion assumption. Second, we used the number of cholinergic amacrine cells (SACs) circumscribed by the DFs of RGCs at corresponding time points as an internal ruler to assess the size of DFs. We found most RGCs exhibit a phase of faster expansion relative to the retina between postnatal day 8 (P8) and P13, followed by a phase of retraction between P13 and adulthood. The morphological alpha cells showed the faster growing phase but not the retraction phase, whereas the morphological ON-OFF direction selective ganglion cells expanded in the same pace as the growing retina. These findings indicate different RGCs show different modes of growth, whereas most subtypes exhibit a fast expansion followed by a retraction phase to reach the adult size.

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Retinal ganglion cell dendrites undergo a visual activity‐dependent redistribution after eye opening

Cited by 61 publications

References 48 publications

Requirement for the paired‐like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation

Requirement for the paired‐like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation

Subtype-dependent postnatal development of direction- and orientation-selective retinal ganglion cells in mice

Changing dendritic field size of mouse retinal ganglion cells in early postnatal development

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