Retinal Functional Changes Measured by Microperimetry in Neovascular Age-Related Macular Degeneration Patients Treated With Ranibizumab

Parravano, Mariacristina; Oddone, Francesco; Tedeschi, Massimiliano; Schiano-Lomoriello, Domenico; Chiaravalloti, Adele; Ripandelli, Guido; Varano, Monica

doi:10.1097/iae.0b013e31819093e6

Cited by 32 publications

(22 citation statements)

References 28 publications

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“…The ELM as a sign of photoreceptor cell survival or rearrangement, as compared to the ellipsoid zone, may thus be more important in determining the improvement in visual acuity [20]. Our study did not reveal a clear association between visual recovery and central macular thickness, in agreement with previous investigations by El-Emam et al [10] and Hayashi et al [21], and in contrast to other studies [22,23,24]. Other morphological parameters such as subfoveal choroidal thickness and the diameter and thickness of the choroidal neovascular membrane were not significantly correlated with final visual acuity or visual improvement, neither in our study nor in previous ones [10,17].…”

Section: Discussioncontrasting

confidence: 57%

Optical Coherence Tomographic Features and Visual Prognosis after Treatment for Idiopathic Choroidal Neovascularization

Cao

Peng²,

You³

et al. 2015

Ophthalmologica

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Background: The aim of this study was to determine whether pretreatment spectral-domain optical coherence tomographic (SD-OCT) features are associated with visual prognosis after treatment for idiopathic subfoveal choroidal neovascularization (ISCNV) with intravitreal ranibizumab. Methods: We retrospectively evaluated SD-OCT images of eyes with ISCNV undergoing treatment with intravitreal ranibizumab with a mean follow-up of 7 months. Results: This study included 22 patients (22 eyes) with a mean age of 32.7 ± 8.1 years. In univariate analysis, better final visual acuity expressed in logMAR units was significantly associated with a lower amount of pretreatment ellipsoid zone defects (p = 0.03; standardized correlation coefficient β = 0.46) and a lower amount of pretreatment external limiting membrane (ELM) damage (p = 0.007; β = 0.56). All other SD-OCT parameters were not significantly associated with final visual acuity. A higher improvement in visual acuity was marginally significantly associated with larger pretreatment ellipsoid zone defects (p = 0.049; β = -0.43). Conclusions: The integrity of the outer retinal layers at baseline, in particular of the ELM, is of importance in predicting the final visual outcome in patients undergoing intravitreal medical therapy for ISCNV.

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Section: Discussioncontrasting

confidence: 57%

Optical Coherence Tomographic Features and Visual Prognosis after Treatment for Idiopathic Choroidal Neovascularization

Cao

Peng²,

You³

et al. 2015

Ophthalmologica

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“…Although numerous reports have shown the correlation of CMT with visual function in various diseases, [33][34][35] we found that foveal thickness did not always reflect the final BCVA of eyes after treatment for wet AMD. This is in agreement with studies by Hayashi et al 25 and Salinas-Alamán et al 36 However, Shin et al 7 reported the association between the baseline increased CMT and the poor final photoreceptor integrity.…”

Section: Discussionmentioning

confidence: 71%

Correlation of Spectral Domain Optical Coherence Tomography Characteristics With Visual Acuity in Eyes With Subfoveal Scarring After Treatment for Wet Age-Related Macular Degeneration

El-Emam

Chhablani²,

Barteselli³

et al. 2013

Retina

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“…14 On the contrary, Parravano et al 15 noted that although maximum gain in visual acuity is at 4 weeks, retinal sensitivity continued to improve until the end of the study at 6 months. All patients in this study had at least 12 months of follow-up.…”

Section: Discussionmentioning

confidence: 97%

Quality of fixation in eyes with neovascular age-related macular degeneration treated with ranibizumab

Sivaprasad

Pearce

Chong

2011

Eye

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Aims To define factors that determine the location and stability of fixation in patients with neovascular age-related macular degeneration (NV-AMD) treated with intravitreal ranibizumab injections. Methods The location and stability of fixation using microperimetry were determined in 77 eyes treated with ranibizumab for NV-AMD for at least 12 months. All patients were treated with three injections of ranibizumab 0.5 mg, 1 month apart and retreated according to predefined criteria. The fixation parameters were correlated to the visual acuity, and quantitative measures on OCT. Results The location of fixation was predominantly central in 52.6%, poor central fixation in 9.2%, and predominantly eccentric fixation in 38.2%. The fixation was stable in 65%, relatively unstable in 25%, and unstable in 10%. Visual acuity was the only factor that determined the stability and location of fixation. The characteristics of fixation were not related to the macular thickness or volume as measured by OCT. Conclusions Better visual outcome ensures central and stable fixation. Quantitative measures of OCT parameters do not determine fixation. Further studies on morphological features of the macula may provide some insight into the determinants of fixation.

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Retinal Functional Changes Measured by Microperimetry in Neovascular Age-Related Macular Degeneration Patients Treated With Ranibizumab

Cited by 32 publications

References 28 publications

Optical Coherence Tomographic Features and Visual Prognosis after Treatment for Idiopathic Choroidal Neovascularization

Optical Coherence Tomographic Features and Visual Prognosis after Treatment for Idiopathic Choroidal Neovascularization

Correlation of Spectral Domain Optical Coherence Tomography Characteristics With Visual Acuity in Eyes With Subfoveal Scarring After Treatment for Wet Age-Related Macular Degeneration

Quality of fixation in eyes with neovascular age-related macular degeneration treated with ranibizumab

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