Retinal findings in patients with COVID-19

Abstract

Tokyo, Japan) and XR Avanti SD-OCT (Optovue, Fremont, CA, USA).All patients showed hyper-reflective lesions at the level of ganglion cell and inner plexiform layers more prominently at the papillomacular bundle in both eyes (figure). Results of OCT-angiography and ganglionar cells complex analysis appeared normal. Furthermore, four patients presented subtle cotton wool spots and microhaemorrhages along the retinal arcade, observed on fundus examination, color fundus photography, and red-free imaging. Visual acuity and pupillary reflexes were normal in all eyes, and we detected no symptoms or signs of intraocular inflammation.Although animal models suggest ocular lesions could include retinitis and optic neuritis, 3,4 this is, to the best of our knowledge, the first report of retinal findings possibly associated with COVID-19 infection in humans. Ganglion cell and plexiform layer findings could be associated with CNS manifestations that have been described in animal studies 4 and in COVID-19 neurological events. 5 We declare no competing interests.

Retinal involvement and ocular findings in COVID‐19 pneumonia patients 

“…Hence, it cannot be excluded that their ndings may be ascribed to pre-existing non-COVID-19-related systemic diseases affecting the retina, such as hypertensive or diabetic retinopathy or other infectious diseases. [40][41][42][43] In our cohort, largely composed of subjects with severe COVID-19, we merged retinal ndings with baseline anamnestic ndings. Nevertheless, our negative results should also be attributed to the ongoing immune modulating treatment, including steroids or tocilizumab, that could have concealed ophthalmoscopic ndings.…”

Cardiac Troponin I Associated with Poor Prognosis and Death Risk in 726 Severe and Critical COVID-19 Patients: A Retrospective Cohort Study

“…However, the differences between the severe and critical groups suggest that patients with severe COVID-19 may have sustained varying degrees of cardiac damage as the disease progresses. Recent studies have also indicated that multiple serious sequelae persisted in patients who recovered from severe COVID-19 disease, including massive heart impairment [22,23].…”

Ocular findings and retinal involvement in COVID-19 pneumonia patients: A cross-sectional study in an Italian referral centre

“…Hence, it cannot be excluded that their ndings may be ascribed to pre-existing non COVID-19-related systemic diseases affecting the retina, such as hypertensive or diabetic retinopathy or other infectious diseases. [40][41][42] In our cohort, largely composed of subjects with severe COVID-19, we merged retinal ndings with baseline anamnestic. Nevertheless, our negative results should also be attributed to the ongoing immune modulating treatment, including steroids or Tocilizumab, that could have concealed ophthalmoscopic ndings.…”