Retinal complications of bone marrow and solid organ transplantation

Moon, Suk J.; Mieler, William F.

doi:10.1097/00055735-200312000-00018

Cited by 40 publications

(24 citation statements)

References 51 publications

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“…Organ transplant procedures require treatments with high doses of glucocorticoids and vasopressive catecholamines and stimulate the endogenous production of stress hormones increasing the risk of CSCR. Indeed, there are numerous reports of CSCR following organ transplantation, the more frequently involved interventions being: kidney, bone marrow and heart transplantations (Chaine et al, 2001;Cheng et al, 2002;Chung et al, 2007;Farzan et al, 2014;Fawzi et al, 2006;Fawzi and Cunningham, 2001;Friberg and Eller, 1990;Kamoun et al, 2005;Karashima et al, 2002;Kian-Ersi et al, 2008;Moon and Mieler, 2003;Oliaei et al, 2007;Polak et al, 1995;Sabet-Peyman et al, 2012;Singh et al, 2003). Finally, allergy has been suggested to favor CSCR, yet various allergic manifestations are managed with local or systemic corticosteroids and the distinction between the contribution of allergy or its treatment remains to be determined (Edalati et al, 2009).…”

Section: Corticosteroidsmentioning

confidence: 99%

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Daruich

Matet

Dirani

et al. 2015

Progress in Retinal and Eye Research

793

996

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Central serous chorioretinopathy (CSCR) is a major cause of vision threat among middle-aged male individuals. Multimodal imaging led to the description of a wide range of CSCR manifestations, and highlighted the contribution of the choroid and pigment epithelium in CSCR pathogenesis. However, the exact molecular mechanisms of CSCR have remained uncertain. The aim of this review is to recapitulate the clinical understanding of CSCR, with an emphasis on the most recent findings on epidemiology, risk factors, clinical and imaging diagnosis, and treatments options. It also gives an overview of the novel mineralocorticoid pathway hypothesis, from animal data to clinical evidences of the biological efficacy of oral mineralocorticoid antagonists in acute and chronic CSCR patients. In rodents, activation of the mineralocorticoid pathway in ocular cells either by intravitreous injection of its specific ligand, aldosterone, or by over-expression of the receptor specifically in the vascular endothelium, induced ocular phenotypes carrying many features of acute CSCR. Molecular mechanisms include expression of the calcium-dependent potassium channel (KCa2.3) in the endothelium of choroidal vessels, inducing subsequent vasodilation. Inappropriate or over-activation of the mineralocorticoid receptor in ocular cells and other tissues (such as brain, vessels) could link CSCR with the known co-morbidities observed in CSCR patients, including hypertension, coronary disease and psychological stress.

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Section: Corticosteroidsmentioning

confidence: 99%

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Daruich

Matet

Dirani

et al. 2015

Progress in Retinal and Eye Research

793

996

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show abstract

“…Although the main target of gamma irradiation is the bone marrow, injury to other tissues including the central nervous system (CNS) and the retina have also been reported. [2][3][4][5][6] Closer examination of the cellular response in the CNS, including the retina, following radiation and BMT is crucial for the development of new strategies for mitigating radiation-induced injury to these tissues. BMT is also commonly used as a research tool to create chimeric animal models whose bone marrow derived cells (BMDCs) carry a reporter gene or other constructs that can be traced in the host.…”

Section: Introductionmentioning

confidence: 99%

In vivo tracking of hematopoietic cells in the retina of chimeric mice with a scanning laser ophthalmoscope

et al. 2012

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“…6 Treatment directed at the primary disease process will lead to the resorption of the subretinal fluid in many of these eyes. The development of bilateral serous retinal detachment, by comparison, has been reported to occur generally secondary to systemic conditions such as organ or bone marrow transplantation, 7,8,9,10 breast cancer, 11 anemia, 12 Alport's syndrome 13 and others. 14,15,16 The medical literature has supported the causal relationship between exogenous steroid use and the development of unilateral and bilateral central serous chorioretinopathy (CSR), as well.…”

Section: Discussionmentioning

confidence: 99%

810 nm diode grid laser treatment for massive chronic serous retinal detachment following combined kidney and pancreas organ transplantation

Kaplan

Friberg

2004

Seminars in Ophthalmology

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An insulin-dependent diabetic woman of 42 years received a combined pancreas and kidney transplant five years prior to referral to our clinic for ophthalmic consultation. Her systemic immunosupression included oral steroids and she subsequently developed huge bilateral central serous retinal detachments affecting both posterior poles and the temporal midperiphery of the left eye. Her vision was reduced to count fingers (CF) in both eyes. Fluorescein angiography (FA) revealed diffuse mild retinal pigment epithelium (RPE) staining in both eyes. As an empiric treatment grid laser photocoagulation with an 810 nm diode laser (Iridex Corp., Mountain View, California) was performed with complete resorption of subretinal fluid in both eyes and visual improvement to 20/70 in the right eye and 20/200 in the left eye at 18 months post-treatment. In patients diagnosed with atypical central serous retinal detachment whose fluorescein angiogram displays widespread RPE damage and in whom systemic steroids are medically necessary, diode grid laser photocoagulation may be a reasonable treatment option.

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Retinal complications of bone marrow and solid organ transplantation

Abstract: Understanding of these clinical entities of the posterior segment is important in minimizing the potentially sight-threatening complications from bone marrow and solid organ transplantation.

Cited by 40 publications

References 51 publications

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

In vivo tracking of hematopoietic cells in the retina of chimeric mice with a scanning laser ophthalmoscope

810 nm diode grid laser treatment for massive chronic serous retinal detachment following combined kidney and pancreas organ transplantation

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