Retinal changes produced by phototherapy

Sisson, Thomas R. C.; Clauser, Stanley C.; Glauser, Elinor M.; Tasman, William; Kuwabara, Toichiro

doi:10.1016/s0022-3476(70)80327-4

Cited by 69 publications

(27 citation statements)

References 3 publications

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“…retinal changes similar to those seen in infants with ROP (15,16), and were chosen as experimental animals. Ten newborn piglets (2-4 days old) weighing 1.45 f 0.1 1 kg (mean & SEM) were used.…”

Section: Experimental Animals Piglets Have Been Shown To Developmentioning

confidence: 99%

The Effect of Arterial Pco2-Variations on Ocular and Cerebral Blood Flow in the Newborn Piglet

et al. 1989

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Although hyperoxia is considered a major risk factor for the development of ROP (4), experimental data and clinical studies have also pointed at other factors. Thus, hypercarbia (4), hypocarbia (5) and hypoxemia (6, 7) have been associated with the development of ROP.At least some putative major risk factors in the development of ROP affect cerebral and ocular blood flow (8,9). Experimental work with adult cats, as well as with newborn lambs and piglets, has shown that hypercarbia influences ocular and cerebral blood flows, although the blood flow response in the retina may differ from that of the choroid (10-12). However, studies on ocular blood flow in the neonate are few (13), and to our knowledge there are no reports on the influence of hypocarbia on ocular blood flow in the neonatal period.Hypocarbia and hypercarbia have opposite effects on cerebral vasculature, hypercarbia increasing cerebral blood flow, hypo-

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Section: Experimental Animals Piglets Have Been Shown To Developmentioning

confidence: 99%

The Effect of Arterial Pco2-Variations on Ocular and Cerebral Blood Flow in the Newborn Piglet

et al. 1989

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“…Ba l l o w it z et al [2] reported repressed rates of growth and other undesirable sequelae following prolonged phototherapy of infant rats with unfiltered blue lamps [8], Sisson et al [20] noted severe retinal changes in piglets exposed to unfiltered blue light. Cytochrome enzymes can be inactivated by intense blue radiation [13] and other pigments that absorb in this wavelength range may also be affected [24], These considerations indi cate the need for caution at the clinical level and underscore the need for de limiting the wavelength band and establishing minimal time and intensity parameters.…”

Section: Resultsmentioning

confidence: 99%

Photodegradation of Serum Bilirubin in the Gunn Rat

Hewitt¹,

Klein²,

Lucey³

1972

Neonatology

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“…Piglets have been shown to develop retinal changes when exposed to light [18,19]. The newborn piglets (n = 22) (2-4 days old) weighing 1.5 ± 0.2 kg (blue group), 1.4 ± 0.3 kg (white group) and 1.4 ± 0.2 kg (green group) (± SEM) were obtained from a local farmer and removed from the sow on the morn ing the study was performed.…”

Section: Some Of the Risk Factors Associated Withmentioning

confidence: 99%

“…Compared to current recommended levels of office light, 40-50 footcandles (ftc), the average level of light recently reported for NICUs were 50-90 ftc, with peak levels fre quently over 220 ftc [16]. Furthermore, dif ferences concerning various light spectra have been discussed regarding efficiency and complications during phototherapy [17,18].…”

Section: Surgical Proceduresmentioning

confidence: 99%

Effect of Different Phototherapy Lights on Retinal and Choroidal Blood Flow

Stiris

Hall²,

Christensen³

et al. 1991

Dev Pharmacol Ther

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The response of retinal (RBF) and choroidal (ChBF) blood flow to illumination with light with different spectra was investigated in spontaneously breathing newborn piglets. After 1 h in complete darkness, the animals were exposed to blue, white or green light in such a manner that equal energy was delivered to the eye. RBF and ChBF showed different flow responses. After 60 min exposure to blue light, RBF increased from 0.22 ± 0.01 ml/min/g at baseline to 0.32 ± 0.03 ml/min/g (± SEM) (p < 0.03). Apart from this increase, RBF did not change significantly during any of the experimental settings. ChBF, on the other hand, was significantly affected by illumination. Thus, at 120 min of light exposure all three types of light decreased ChBF significantly from baseline (darkness) levels. Blue light decreased ChBF (mean ± SEM) from 13.78 ± 0.84 to 7.61 ± 0.67 ml/min/g (p < 0.01), white light from 17.43 ± 1.86 to 9.86 ± 1.07 ml/min/g (p < 0.01), and green light from 14.13 ± 1.64 to 8.31 ± 1.30 ml/min/g (p < 0.02). The results indicate that light is an important modulator of ChBF and to a certain extent also RBF. Further, the results suggest that ChBF and RBF are regulated differently.

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Retinal changes produced by phototherapy

Cited by 69 publications

References 3 publications

The Effect of Arterial Pco2-Variations on Ocular and Cerebral Blood Flow in the Newborn Piglet

The Effect of Arterial Pco2-Variations on Ocular and Cerebral Blood Flow in the Newborn Piglet

Photodegradation of Serum Bilirubin in the Gunn Rat

Effect of Different Phototherapy Lights on Retinal and Choroidal Blood Flow

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