Retinal Changes in Otsuka Long-Evans Tokushima Fatty Rats (Spontaneously Diabetic Rat)—Possibility of a New Experimental Model for Diabetic Retinopathy

Lu, Zhongyang

doi:10.1016/s0021-5155(02)00631-7

Cited by 41 publications

(48 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Retinal capillary changes in OLETF rats were examined after 56 weeks of age [48, 55]. In the retinal capillaries, basement membranes were thicker, and the ratio of pericyte area to the capillary cross-section area was lower than that of lean rats.…”

Section: Occular Lesionsmentioning

confidence: 99%

Diabetic Complications in Obese Type 2 Diabetic Rat Models

et al. 2014

View full text Add to dashboard Cite

We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Torii (SDT) fatty rat. Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of β cells, and degenerative changes, such as islet atrophy and fibrosis of islet with infiltration of inflammatory cells. Renal lesions in tubuli and glomeruli were observed, and nodular lesions in glomeruli were notable changes in OLETF and SDT fatty rats. Among retinal changes, folding and thickening were interesting findings in SDT fatty rats. A decrease of motor nerve conduction velocity with progression of diabetes was presented in obese diabetic rats. Other diabetic complications, osteoporosis and sexual dysfunction, were also observed. Observation of bone metabolic abnormalities, including decrease of osteogenesis and bone mineral density, and sexual dysfunction, including hypotestosteronemia and erectile dysfunction, in obese type 2 diabetic rats have been reported.

show abstract

Section: Occular Lesionsmentioning

confidence: 99%

Diabetic Complications in Obese Type 2 Diabetic Rat Models

et al. 2014

View full text Add to dashboard Cite

show abstract

“…There is thus no evidence for choroidal neovascularisation (CNV) as observed, for example, in macular degeneration 20. However, capillary constrictions and dropout appear similar between the two beds,14 17 21 22 as does tortuousity within the major vessels 21 22…”

Section: Discussionmentioning

confidence: 99%

VEGF-induced choroidal damage in a murine model of retinal neovascularisation

Tee

Penrose

O'Shea

et al. 2008

British Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…OLETF is a model for spontaneous type 2 diabetes and obesity and harbors a mutation in the initiation codon of the G-proteincoupled receptor GPR10 that leads to obesity [131]. Disease onset is characterized by increased blood glucose that is observed by 5-6 months [132]. Six weeks following the onset of hyperglycemia, microvessel-related symptoms are observed, including leukocyte entrapment in retinal microcirculation [26].…”

Section: Rat Genetic Models Of Drmentioning

confidence: 99%

Animal Models of Diabetic Retinopathy

Chen

Stitt

2015

Animal Models of Ophthalmic Diseases

View full text Add to dashboard Cite

Purpose of Review Diabetic retinopathy (DR) is one of the most common complications associated with chronic hyperglycemia seen in patients with diabetes mellitus. While many facets of DR are still not fully understood, animal studies have contributed significantly to understanding the etiology and progression of human DR. This review provides a comprehensive discussion of the induced and genetic DR models in different species and the advantages and disadvantages of each model. Recent FindingsRodents are the most commonly used models, though dogs develop the most similar morphological retinal lesions as those seen in humans, and pigs and zebrafish have similar vasculature and retinal structures to humans. Nonhuman primates can also develop diabetes mellitus spontaneously or have focal lesions induced to simulate retinal neovascular disease observed in individuals with DR. Summary DR results in vascular changes and dysfunction of the neural, glial, and pancreatic β cells. Currently, no model completely recapitulates the full pathophysiology of neuronal and vascular changes that occur at each stage of diabetic retinopathy; however, each model recapitulates many of the disease phenotypes.

show abstract

Retinal Changes in Otsuka Long-Evans Tokushima Fatty Rats (Spontaneously Diabetic Rat)—Possibility of a New Experimental Model for Diabetic Retinopathy

Cited by 41 publications

References 20 publications

Diabetic Complications in Obese Type 2 Diabetic Rat Models

Diabetic Complications in Obese Type 2 Diabetic Rat Models

VEGF-induced choroidal damage in a murine model of retinal neovascularisation

Animal Models of Diabetic Retinopathy

Contact Info

Product

Resources

About