Retinal artery vasculitis secondary to administration of influenza vaccine

Williams, Gwyn Samuel; Evans, Samuel Lewin; Yeo, Damien; Al‐Bermani, Ayad

doi:10.1136/bcr-2015-211971

Cited by 14 publications

(13 citation statements)

References 7 publications

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“… 2 , 17 More recently Williams described a case of anterior uveitis and retinal arterial vasculitis 8 weeks following routine annual inactivated influenza immunization. 5 The influenza vaccine reported in this instance was similar to the one our patient received. Both cases from Blumberg et al and Williams et al reported no recurrences of uveitis or retinal vasculitis following topical 1% prednisolone treatment.…”

Section: Discussionsupporting

confidence: 65%

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Acute macular neuroretinopathy associated with influenza vaccination with decreased flow at the deep capillary plexus on OCT angiography

Liu

Nesper

Fawzi

et al. 2018

American Journal of Ophthalmology Case Reports

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PurposeWe report a case of acute macular neuroretinopathy (AMN) following routine annual inactivated influenza vaccination. Projection-resolved optical coherence tomography angiography (PR-OCTA) was used to analyze the retinal capillary flow within the AMN lesion.ObservationsOur patient reported visual symptoms of her right eye nine days after routine annual influenza vaccination. Multimodal imaging revealed small vessel peripheral vasculitis and AMN in the affected eye. Infectious, immunologic, and hypercoagulable etiologies were investigated and excluded. PR-OCTA B-scans within the AMN lesion demonstrated reduced flow in the deep capillary plexus (DCP) at baseline with relatively improved flow signal in the DCP on follow up, 3 weeks later.Conclusions and importanceWe report a new association of AMN following routine inactivated influenza immunization. Recent influenza vaccination should be included in the differential diagnosis for patients presenting with AMN. PR-OCTA demonstrated compromised DCP flow in the AMN lesion which has not been previously described.

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Section: Discussionsupporting

confidence: 65%

“… 2 , 8 , 11 , 12 , 17 Ocular involvement is extremely rare and to our knowledge there are only 2 reported cases of isolated ocular complications following influenza vaccination. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Acute macular neuroretinopathy associated with influenza vaccination with decreased flow at the deep capillary plexus on OCT angiography

Liu

Nesper

Fawzi

et al. 2018

American Journal of Ophthalmology Case Reports

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“…It remains unclear if the reported retinal vascular events in our study are specific side effects of COVID-19 vaccinations. Ocular side effects, such as retinal vascular occlusions, AMN, and anterior and posterior uveitis, were also observed after vaccination for other diseases, such as influenza or hepatitis B [15,18,19]. Reports on ocular side effects after COVID-19 vaccinations are rare so far [20].…”

Section: Discussionmentioning

confidence: 99%

Retinal Vascular Events after mRNA and Adenoviral-Vectored COVID-19 Vaccines—A Case Series

et al. 2021

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Background: To describe cases of retinal vascular events shortly after administration of mRNA or adenoviral-vectored COVID-19 vaccines. Design: Retrospective, multicenter case series. Methods: Six cases of retinal vascular events shortly after receiving COVID-19 vaccines. Results: A 38-year-old, otherwise healthy male patient presented with branch retinal arterial occlusion four days after receiving his second dose of SARS-CoV-2 vaccination with Comirnaty® (BioNTech®, Mainz, Germany; Pfizer®, New York City, NY, USA). An 81-year-old female patient developed visual symptoms twelve days after the second dose of SARS-CoV-2 vaccination with Comirnaty® and was diagnosed with a combined arterial and venous occlusion in her right eye. A 40-year-old male patient noticed blurry vision five days after his first dose of SARS-CoV-2 vaccination with Comirnaty® and was diagnosed with venous stasis retinopathy in his left eye. A 67-year-old male was diagnosed with non-arteritic anterior ischemic optic neuropathy in his right eye four days after receiving the first dose of Vaxzevria® (AstraZeneca®, Cambridge, UK). A 32-year-old man presented with a sudden onset of a scotoma two days after receiving the second dose of SARS-CoV-2 vaccination with Spikevax® (Moderna, Cambridge, UK) and was diagnosed with a circumscribed nerve fiber infarction. A 21-year-old female patient developed an acute bilateral acute macular neuroretinopathy three days after receiving the first dose of SARS-CoV2-vaccine Vaxzevria® (AstraZeneca®, Cambridge, UK). Conclusion: This case series describes six cases of retinal vascular events shortly after receiving mRNA or adenoviral-vectored COVID-19 vaccines. The short time span between received vaccination and occurrence of the observed retinal vascular events raises the question of a direct correlation. Our case series adds to further reports of possible side effects with potential serious post-immunization complications of COVID-19 vaccinations.

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“…published the case of a 78-year-old Caucasian woman who presented with a single unilateral arterial vasculitis 8 weeks after influenza vaccination. [ 91 ] Uveitis and optic neuritis were reported in one case by Blumberg et al . [ 92 ] Recrudescence of a previously quiet inflammation was reported in a 77-year old female after influenza immunization, suggesting that such a vaccine might not only trigger de novo inflammatory processes but also exacerbate pre-existing inflammation.…”

Section: Vaccines Induce Uveitismentioning

confidence: 99%

Drug-induced uveitis: A review

Agarwal

Majumder

Babu

et al. 2020

Indian J Ophthalmol

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Uveitis maybe induced by the use of various medications known as drug-induced uveitis (DIU), though rare it is an important cause of uveitis which one needs to be aware of. The drugs may be administered through any route including systemic, topical, and intravitreal. Ocular inflammation can be in the form of anterior, intermediate, posterior or pan uveitis, and rarely may present as episcleritis and scleritis. Identification of drug as the offending agent of uveitis is important as many a times stopping the drug may help recover the uveitis or the concomitant use of corticosteroids. An extensive literature review was done using the Pubmed. An overview of DIU is provided as it is important for us to be aware of this clinical entity.

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Retinal artery vasculitis secondary to administration of influenza vaccine

Cited by 14 publications

References 7 publications

Acute macular neuroretinopathy associated with influenza vaccination with decreased flow at the deep capillary plexus on OCT angiography

Acute macular neuroretinopathy associated with influenza vaccination with decreased flow at the deep capillary plexus on OCT angiography

Retinal Vascular Events after mRNA and Adenoviral-Vectored COVID-19 Vaccines—A Case Series

Drug-induced uveitis: A review

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