Retinal Arteriosclerosis Secondary to Vein Obstruction

Wise, George N.

doi:10.1001/archopht.1959.00940090768013

Cited by 11 publications

(9 citation statements)

References 8 publications

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“…Salus (15) believes that "real" silverwire and copperwire arteries are the only indications of a serious vasculopathy. These silverwire arteries have also been observed without hypertension (1,20,22).…”

Section: Singe I F 'mentioning

confidence: 95%

“…For example, a sufficient distinction was not always made between arteriosclerosis, atherosclerosis and arteriolosclerosis. At present it is generally accepted that the ophthalmoscopically visible retinal arteries are mainly arterioles (8,16,17,20,22). Only the Submitted for publication March 9, 1964. central retinal artery and the beginning of the first branches, where they have not left the papilla, are arteries.…”

mentioning

confidence: 99%

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Hypertension and Changes of the Fundus Oculi

Buchem¹,

Heuvel‐Aghina²,

Heuvel

1964

Journal of Internal Medicine

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Section: Singe I F 'mentioning

confidence: 95%

mentioning

confidence: 99%

Hypertension and Changes of the Fundus Oculi

Buchem¹,

Heuvel‐Aghina²,

Heuvel

1964

Journal of Internal Medicine

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“…Microaneurysms have been described as focal regions of endothelial proliferation and perhaps abortive attempts at intraretinal neovascularization [71]. This notion was first put forward by Wise [99], although at the ultrastructural level we have never found this to be the case [87]. However, the most significant evidence against microaneurysms representing sites of failed neovascularization (NV) is that they are predominantly located at the arterial side of the circulation and NV invariably arises from the venous side.…”

Section: Lesions Of Long‐term Diabetic Retinopathymentioning

confidence: 99%

Arteriolar Involvement in the Microvascular Lesions of Diabetic Retinopathy: Implications for Pathogenesis

Gardiner¹,

Archer²,

Curtis³

et al. 2007

Microcirculation

173

144

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Diabetic retinopathy (DR) is the most widespread complication of diabetes mellitus and a major cause of blindness in the working population of developed countries. The clinicopathology of the diabetic retina has been extensively studied, although the relative contribution of the various biochemical and molecular sequelae of hyperglycemia remains ill defined. Many neural and microvascular abnormalities occur in the retina of short-term diabetic animals but it remains uncertain how closely these acute changes relate to chronic human disease. It is important to determine the relationship between alterations observed within the first weeks or months in short-term animal models, and human disease, where clinically manifest retinopathy occurs only after durations of diabetes measured in years. This review is focused on the retinal microvasculature, although it should be appreciated that pathological changes in this system often occur in parallel with abnormalities in the neural parenchyma that may be derivative or even causal. Nevertheless, it is useful to reevaluate the microvascular lesions that are manifest in the retina during diabetes in humans and long-term animal models, since in addition to providing useful clues to the pathogenic basis of DR as a disease entity, it is in the deterrence of such changes that the efficacy of any novel treatment regimes will be measured. In particular, an emphasis will be placed on the relatively unappreciated role of arteriolar dysfunction in the clinical manifestations and pathology of this disease.

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“…In connection with vein occlusions advanced areteriosclerotic changes in the retinal arteries (Wise 1958; Rubinstein &Jones 1976) are common. The crossing of arteries and veins have been suggested to be a predisposing factor in BVO.…”

Section: Factors Involved In the Formation Of Avenous Occlusionmentioning

confidence: 99%

Arguments for a vascular glaucoma etiology

Sonnsjö

Krakau

1993

Acta Ophthalmologica

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A material of Open Angle Glaucoma (G) collected by an eye practitioner (B S) from 1980 to 1991 is analysed with special respect to the occurrence of disc haemorrhages (Hs) and retinal vein occlusions (VOs). There is a close association between Hs and VOs and G, which in all categories increases with increasing follow-up time. Furthermore, the occurrence of mixed cases--H in one eye and VO in the same or the other--support the opinion that Hs, branch vein occlusions and central vein occlusions are manifestations of the same vascular disease, the difference between them being the size of the vessel affected. The well known morphological changes in the retinal veins of glaucomas and in central vein occlusions are endothelial proliferations causing progressive increase of flow resistance. Similar changes most probably also cause branch occlusions and disc haemorrhages. The vascular affection which obstructs the vessels with hindrance of the blood flow and impaired nutrition of neuronal tissue, might be the primary cause of glaucoma.

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Retinal Arteriosclerosis Secondary to Vein Obstruction

Cited by 11 publications

References 8 publications

Hypertension and Changes of the Fundus Oculi

Hypertension and Changes of the Fundus Oculi

Arteriolar Involvement in the Microvascular Lesions of Diabetic Retinopathy: Implications for Pathogenesis

Arguments for a vascular glaucoma etiology

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