Retinal and choroidal thickness measurements using spectral domain optical coherence tomography in anterior and intermediate uveitis

Abstract

BackgroundMacular edema is a common cause of visual loss at uveitic patients. The aim of our study was to investigate retinal and choroidal thickness at the macula in anterior (AU) and intermediate (IMU) uveitis and in healthy individuals using spectral domain optical coherence tomography (SD-OCT).MethodsCase-control study of 21 patients with AU and 23 patients with IMU and 34 age-matched healthy controls was performed with Spectralis SD-OCT (Heidelberg Engineering, Germany). High resolution SD-OCT scans and macular mapping were applied for automated measurement of retinal thickness. Standardized, masked manual measurement of the choroidal thickness was performed in the center of the ETDRS fields on enhanced depth imaging (EDI) scans. Evaluation of central retinal subfield thickness, 3 mm and 6 mm perifoveal rings was performed in the corresponding ETDRS zones in patient groups.ResultsThe mean central retinal subfield thickness was significantly higher in IMU (368.65 ± 115.88 μm, p = 0.0003), but not significantly different in AU (290.42 ± 26.37 μm p = 0.6617) compared to that of in controls (278.55 ± 18.31 μm). In both uveitis groups retina was significantly thicker in the 3 and 6 mm perifoveal rings than that of in controls (359 ± 15.24 μm in AU and 390.55 ± 70.90 μm in IMU vs 345,41 ± 15.28 μm in the control group, p = 0.0388 and p < 0.0001) in the 3 mm and (313.83 ± 16.63 μm in AU and 343.33 ± 57.29 μm in IMU vs 299 ± 13.82 μm in the control group, p = 0.0171 and p < 0.0001) in the 6 mm ring. Central choroidal thickness was 311.94 ± 60.48 μm in the control eyes, showed no significant difference in AU (312.61 ± 90.35 μm) and IMU (303.17 ± 93.66 μm) eyes, and was also similar at the perifoveal rings.ConclusionSignificant topographical changes could be detected in the macula of AU and IMU patients. Retinal thickness in the perifoveal rings was increased both in AU and IMU, but in the center only in IMU. Choroidal thickness seems to be unaffected by uveitis, even in the presence of macular edema, at least in the early stage of the inflammatory disease process.

Choroidal Vascularity Index (CVI) - A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis?

“…OCT has been universally adopted as an essential tool in management and follow up of uveitis. [ 32 , 38 , 39 , 45 , 46 ] Many attempts have been made to examine retinal, vitreoretinal and choroidal features using this non-invasive modality. [ 9 , 14 , 15 , 17 ] EDI OCT has revolutionised the way to look at the characteristic features in choroid in patients with retinal diseases and uveitis.…”

Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis

“…Besides detection of various macular pathologies, measurement of general anatomical indices such as central retinal thickness (CRT) and macular volume (MV) has been correlated in previous studies with visual acuity and response to therapy. 2,3 While previous studies using SD-OCT focused on uveitis patients with manifest secondary changes of the retina, primarily CME, [2][3][4][5][6][7][8][9][10][11][12][13][14] we were interested to analyze the macular morphology in a large series of consecutive patients with different types of uveitis, using SD-OCT. We assessed the CRT, MV, and presence of cystoid macular edema (CME), diffuse macular edema (DME), serous retinal detachment (SRD), ERM with (ERM+) and ERM without (ERM − ) retinal surface wrinkling.…”

The state of the choroid in children with anterior uveitis assessed by optical coherence tomography

“…Попытки оценить роль этого параметра при передних увеитах [7][8][9][10][11][12][13][14] дали противоречивые результаты. В ряде работ обнаружено увеличение толщины сосудистой оболочки в субфовеолярной и парафовеолярной зонах в период активности воспаления [8,10,[12][13][14], а H. Yan и соавт.…”

“…Однако, по данным Z. Géhl и соавт. [7], у пациентов с передними увеитами толщина сосудистой оболочки в субфовеолярной и парафовеолярной зонах достоверно не отличалась от таковой на здоровых глазах. M. Wiacek и соавт.…”