Retinal and Choroidal Thickness in Patients with High Myopia without Maculopathy

Teberik, Kuddusi; Kaya, Murat

doi:10.12669/pjms.336.13726

Cited by 25 publications

(23 citation statements)

References 24 publications

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“…13 We previously found, in guinea pigs, that ChBP and ChT simultaneously decreased in experimental myopia and increased during recovery. 21 Consistent with our findings, others have reported that changes of ChBP 22,23 and ChT 24,25 were strongly correlated with the development of myopia in clinical settings. Additionally, previous studies showed that in humans, a 6-D accommodation stimulus that produced a myopia shift was associated with a reduced ChT.…”

Section: Discussion the Inhibition Of Fdm In Guinea Pigs Could Be Medsupporting

confidence: 92%

“…18,19 In both models, the thinned choroid becomes thicker after removal of the myopia-inducing stimulus. 16,20,21 Similarly, many clinical studies have found that reductions of choroidal blood flow 22,23 and ChT 24,25 are associated with high myopia. The close correlation between choroidal blood perfusion (ChBP) and ChT, and their bidirectional association with the development of myopia and the recovery from it, were clearly demonstrated in our previous studies with the guinea pig model.…”

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confidence: 97%

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Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs

Zhou

Zhang

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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In guinea pigs, choroidal thickness (ChT) and choroidal blood perfusion (ChBP) simultaneously decrease in experimental myopia, and both increase during recovery. However, the causal relationship between ChBP and myopia requires further investigation. In this study, we examined the changes of ChBP with three different antimyopia treatments. We also actively increased ChBP to examine the direct effect on myopia development in guinea pigs. METHODS. Experiment 1: Guinea pigs wore occluders on the right eye for two weeks to induce form-deprivation myopia (FDM). Simultaneously they received daily antimyopia treatments: peribulbar injections of atropine or apomorphine or exposure to intense light. Experiment 2: The vasodilator prazosin was injected daily into the form-deprivation eyes to increase ChBP during the two-week induction of FDM. Other FDM animals received appropriate control treatments. Changes in refraction, axial length, ChBP, ChT, and hypoxia-labeled pimonidazole adducts in the sclera were measured. RESULTS. The antimyopia treatments atropine, apomorphine, and intense light all significantly inhibited myopia development and the decrease in ChBP. The treatments also reduced scleral hypoxia, as indicated by the decrease in hypoxic signals. Furthermore, actively increasing ChBP with prazosin inhibited the progression of myopia, as well as the increase in axial length and scleral hypoxia. CONCLUSIONS. Our data strongly indicate that increased ChBP attenuates scleral hypoxia, and thereby inhibits the development of myopia. Thus ChBP may be a promising target for myopia retardation. As such, it can serve as an immediate predictor of myopia development as well as a long-term marker of it.

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Section: Discussion the Inhibition Of Fdm In Guinea Pigs Could Be Medsupporting

confidence: 92%

mentioning

confidence: 97%

Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs

Zhou

Zhang

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…Although studies have investigated the changes in retinal thickness in other populations, [17][18][19][20][21][22][23][24][25][26][27][28] they have considered only the central retinal region or recruited individuals with high or pathologic myopia, [17,27] and the results have been inconclusive [17][18][19][20][21][22][23][24][25][26][27][28] due to the different methodologies used in the studies. [17][18][19][20][21][22][23][24][25][26][27][28][29] Retinal thickness measurements by OCT vary according to the population being studied; [30] thus, knowledge of such population-based differences in retinal thickness distribution is important in the evaluation, treatment, and follow-up of patients in a particular population and/or with various ocular pathologies. [17,31] However, studies investigating the effects of refraction groups on retinal thickness measurements across different locations have shown different results.…”

Section: Introductionmentioning

confidence: 99%

Myopia and Regional Variations in Retinal Thickness in Healthy Eyes

Zereid

Osuagwu

2020

JOVR

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Purpose: To investigate the effects of refraction on retinal thickness measurements at different locations and layers in healthy eyes of Saudi participants. Methods: Thirty-six randomly selected adults aged 27.0 ± 5.7 years who attended a Riyadh hospital from 2016 to 2017 were categorized into three groups: non-myopic (spherical equivalent refraction [SER], +1.00 to –0.50 diopters [D]), low myopic (SER, – 0.75 to –3.00D), and moderate to high myopic (SER ≤ –3.25D). Full, inner, and outer retinal thicknesses were measured at nine locations by spectral-domain stratus optical coherence tomography (Optovue Inc., Fremont, CA, USA) and were compared according to refractive group and sex. Results: The mean SERs for the non-myopia, low myopia, and moderate to high myopia groups were 0.2 ± 0.6, –1.5 ± 0.5, and –7.5 ± 1.9 D, respectively. Refractive error, but not sex, had significant effects on the retinal layer thickness measurements at different locations (P < 0.05). The parafoveal and outer retinal layers were significantly thicker than the perifoveal and inner retina layers in all groups (P < 0.05). The full foveal thickness was higher and the full parafoveal and perifoveal regions were thinner in moderate to high myopic eyes than in the non-myopic eyes (P < 0.05), but were similar to those in the low myopic eyes (P > 0.05). The foveal thicknesses measured in the inner and outer layers of the retina were higher but the thicknesses measured at the inner and outer layers of the parafoveal and perifoveal regions were lower in moderate to high myopic eyes. Conclusion: There were regional differences in the retinal layer thicknesses of healthy Saudi eyes, which was dependent on the central refractions. This is important when interpreting retinal nerve fiber layer thicknesses in myopia and disease management in Saudi participants.

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“…Also, a negative correlation was reported between refraction in all patients and their measures of CT "nasal, subfoveal and temporal", with p-value less than 0.001. This was in accordance with Teberik and Kaya [13] whose prospective study included 65 individuals divided into: high myopic patients [30 patients] and 35 healthy subjects. OCT was used for choroidal imaging in the nasal, temporal and subfoveal region.…”

Section: Discussionmentioning

confidence: 78%

Choroidal thickness in different degrees of myopia measured by enhanced depth imaging mode optical coherence tomography

Abd-Elkhalek

Abdelrahman

Aly

et al. 2022

International Journal of Medical Arts

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Article information Background: Choroidal thickness [CT] is associated with many ocular conditions. Different generations of optical coherence tomography [OCT] are important for clinical application. Objective: This study aimed to evaluate the effect of myopia on CT by the use of enhanced depth imaging [EDI] OCT and correlate the measured data with both the axial length [AL] and the refraction. Patients and Methods: A Cross-sectional study included 80 adult patients of both sexes. The patients were divided into 4 groups: [G1, control]: 20 emmetropic subjects. [G2]: 20 myopic patients with refraction up to -6 D. [G3]: 20 myopic patients with refraction >-6 D up to -10 D and [G4]: 20 myopic patients with refraction > -10 D.Spectralis OCT has been utilized in assessing CT in subfoveal region, 500, 1000 and 1500 um temporal and nasal to fovea. Results: A highly statistically significant variation existed among groups considering AL and refraction with G4 having higher values and G2 and G1 having lower values. Regarding CT, the highest value was found in G1 and 2, followed by G3, but the lowest value was found in G4. There was significant positive correlation between refraction in all patients and their AL [p< 0.001], and significant negative correlation appeared between refraction and AL in all patients regarding their all measures of CT [nasal, temporal and subfoveal] [p < 0.001]. Conclusion: Myopia with different degrees caused a decrease in CT compared to its thickness of healthy eyes, with marked thinning in advanced myopia.

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Retinal and Choroidal Thickness in Patients with High Myopia without Maculopathy

Cited by 25 publications

References 24 publications

Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs

Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs

Myopia and Regional Variations in Retinal Thickness in Healthy Eyes

Choroidal thickness in different degrees of myopia measured by enhanced depth imaging mode optical coherence tomography

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