Retinal and Choroidal Biometry in Highly Myopic Eyes with Spectral-Domain Optical Coherence Tomography

Ikuno, Yasushi; Tano, Yasuo

doi:10.1167/iovs.08-3325

Cited by 342 publications

(301 citation statements)

References 32 publications

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“…Both of these studies used the Cirrus OCT, [45][46] which utilised the same retinal boundaries as this study but measured the foveal thickness as an average over 500 µm centred on the fovea rather than at the foveola as in this study. The values found in this study are comparable to myopic foveal thickness measurements using a similar methodology to our own, 29 and to minimum foveal thickness in normal eyes found using a stratus OCT. [45][46][47] Our overall approach to the analysis was conservative because we adopted an independent samples rather than a paired approach, despite having matched our groups for age and axial length. Based on the standard deviation of the foveal thickness measurements and the sample size, the smallest difference between groups detectable in this study was 24.8 and 64.7 µm for retinal and choroidal thickness respectively (with a power of 80% and a significance level of 0.05).…”

Section: Discussionsupporting

confidence: 88%

“…Multiple studies have assessed choroidal thickness in healthy individuals using the OCT, [23][24][27][28][29][30] however, only a few have used a 1060nm system. [27][28] A recent study using 1060nm OCT to investigate the correlation between axial length and choroidal thickness in 34 healthy subjects (64 eyes) aged 19-80 years, found a mean central choroidal thickness of 315m (SD 106m), with the choroid thinnest in the nasal parafovea.…”

Section: Discussionmentioning

confidence: 99%

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Retinal and Choroidal Thickness in Early Age-Related Macular Degeneration

Wood

Binns

Margrain

et al. 2011

American Journal of Ophthalmology

129

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Retinal and Choroidal Thickness in Early Age-Related Macular Degeneration

Wood

Binns

Margrain

et al. 2011

American Journal of Ophthalmology

129

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“…It has been reported that CT was negatively correlated with older age, longer AL, higher IOP, and thicker CCT. [20][21][22][23][24] In our study, multiple linear regression analysis showed that the SFCT was significantly associated with only the change in IOP. This may be due to the change in IOP, which was the most marked factor after surgery.…”

Section: Eyesupporting

confidence: 50%

Changes in choroidal thickness, axial length, and ocular perfusion pressure accompanying successful glaucoma filtration surgery

Kara¹,

Baz

Altan

et al. 2013

Eye

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Purpose To investigate the changes in choroidal thickness (CT), axial length (AL), and ocular perfusion pressure (OPP) accompanying intraocular pressure (IOP) reduction after trabeculectomy. Methods Thirty-nine eyes of 39 patients with primary open-angle glaucoma uncontrolled by medical therapy were included in this prospective and interventional study. All patients underwent a fornix-based trabeculectomy. The CT was measured by enhanced depth imaging-optical coherence tomography. IOP, AL, and systolic/ diastolic blood pressure were also measured, and OPP was calculated. All measurements were performed at baseline and 1 month after surgery. Results The mean IOP was 25.0 ± 5.8 mm Hg at baseline and 11.7 ± 2.6 mm Hg after trabeculectomy (Po0.001), and the mean subfoveal CT was 295±84 mm Hg at baseline and 331±82 mm Hg after trabeculectomy (Po0.001). The mean AL was 23.64 ± 0.98 mm at baseline and 23.54 ± 0.96 mm after trabeculectomy (Po0.001), whereas the mean OPP was 38.8 ± 6.2 mm Hg preoperatively, and 51.1 ± 7.3 mm Hg postoperatively (Po0.001). The change in CT negatively correlated with the change in IOP (r ¼ À 0.785, Po0.001) and AL (r ¼ À 0.693, Po0.001), whereas it positively correlated with the change in OPP (r ¼ 0.418, P ¼ 0.008). Conclusion These results suggest that the large IOP decrease following trabeculectomy causes choroidal thickening.In addition, CT changes are associated with IOP and AL reduction as well as OPP increase.

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“…CT in ME was thinner than in EE in the present study, corroborating previous literature (25,26) . The nasal quadrant was thinner than the fovea and the temporal quadrant, which is in agreement with a previous report (25) .…”

Section: Discussionsupporting

confidence: 93%

Choroidal thickness variation in highly myopic eyes during the water drinking test

Germano¹,

Hatanaka²,

Susanna³

2016

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate variations in choroidal thickness (CT) during the water drinking test (WDT) in emmetropic eyes (EE) and highly myopic eyes (ME) using spectral-domain optical coherence tomography (SD-OCT). Methods: Clinical trial performed at a tertiary care hospital comprising 30 randomly selected eyes. The WDT and SD-OCT macular scans were performed 10 and 45 min after water ingestion in 15 myopic and 15 EE of 15 healthy patients in each group. Primary study outcomes were average macular CT measured by SD-OCT and intraocular pressure (IOP) during the WDT. Results: The mean spherical equivalent refraction was 0.15 ± 0.24 D in emmetropic and -7.1 ± 1.75 D in ME (p<0.001). No statistical differences between EE and ME were observed during the WDT response. EE had higher CT compared with ME at the fovea (361.4 ± 55.4 vs 257.9 ± 95.3; p<0.001), 3 mm nasal to the fovea (158.0 ± 71.8 vs 122.5 ± 54.5; p=0.047), and 3 mm temporally to the fovea (310.6 ± 52.4 vs 247.6 ± 90.1; p=0.05). Regarding CT variation, significant differences in foveal CT at 10 min after water ingestion were observed in both EE and ME, with no statistically significant difference observed between groups. A moderate correlation between IOP peak during the WDT and CT was demonstrated in ME (r=0.52; p=0.04). Conclusions:No statistically significant differences in CT variation during the WDT were observed between EE and ME, indicating similar behavior of the choroidal bed during the WDT in both groups. Further, CT was thinner in highly ME, with CT variation unable to explain elevations in IOP observed during the WDT.

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Retinal and Choroidal Biometry in Highly Myopic Eyes with Spectral-Domain Optical Coherence Tomography

Abstract: Posterior staphyloma formation was a key factor in choroidal thinning in highly myopic eyes. Choroidal thickness had a greater effect than retinal thickness in highly myopic eyes.

Cited by 342 publications

References 32 publications

Retinal and Choroidal Thickness in Early Age-Related Macular Degeneration

Retinal and Choroidal Thickness in Early Age-Related Macular Degeneration

Changes in choroidal thickness, axial length, and ocular perfusion pressure accompanying successful glaucoma filtration surgery

Choroidal thickness variation in highly myopic eyes during the water drinking test

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