Retiform hemangioendothelioma with lymph node metastasis: A rare entity

Bhutoria, Bhawna; Konar, Abantika; Chakrabarti, Sudipta; Das, Shikha

doi:10.4103/0378-6323.45223

Cited by 35 publications

(45 citation statements)

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“…In the human medical literature, these tumours are considered low-grade malignancies with only two reports of regional lymph node metastasis (Calonje et al, 1994;Bhutoria et al, 2009;Zhang et al, 2010), but with frequent local recurrence and invasiveness. The predominant epidemiology of the tumours includes a female predominance with the majority of the reported cases occurring on the lower limbs (Calonje et al, 1994;Duke et al, 1996;Calonje, 2002;Tan et al, 2005;Ioannidou et al, 2006).…”

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confidence: 97%

Two Canine Malignant Vascular Tumours with Features of Human Retiform Haemangioendothelioma

Lombardini

Summers

2013

Journal of Comparative Pathology

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confidence: 97%

Two Canine Malignant Vascular Tumours with Features of Human Retiform Haemangioendothelioma

Lombardini

Summers

2013

Journal of Comparative Pathology

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“…Because of the infiltrative growth pattern of RH it is difficulty to achieve tumor-free margins, which likely contributes to the high recurrence rate although several cases performed wide local excision with negative margin [14]. So far, only three cases of RH have developed metastases to regional lymph nodes which indicate a very aggressive biological behavior [2,12,19]. However, clinical follow-up ranged from 4 months to 22 years, no distant metastasis has been observed.…”

Section: Discussionmentioning

confidence: 99%

Unusual multiple cutaneous retiform hemangioendothelioma on forearm and neck misdiagnosed as angiosarcoma with metastasis

Pan¹,

Wang²,

Huang³

et al. 2017

Clin Diagn Pathol

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Retiform hemangioendothelioma (RH) is extremely rare, and often involves the skin and subcutaneous tissues of distal extremities in young adults or children. Since its first description by Calonje in 1994, only a few primary multiple cases have been described in the literature. We present a case of unusual primary multiple RH on forearm and neck occurring in a 56 years old female patient. The patient presented with a slow-growing cutaneous plaque-like lesion on her left forearm, followed by another lesion at the site of neck for several years. In the skin biopsy examination, a diagnosis of angiosarcoma with cutaneous metastasis was made based on multiple lesions at different anatomic sites and vasoformative growth pattern with anastomosing channels under the microscopy. However, postoperative histological diagnosis of the lesion was primary multiple RH by thoroughly microscopical inspection and the presence of thin-walled interconnecting vascular channels arranged in a retiform pattern and absence of lymph node metastasis. Despite wide surgical excision with tumor-free margin, the tumor recurred at the neck 3 months after surgery. The second local excision was performed. The patient was on regular follow-up for 18 months without additional treatments. There was no sign of recurrence or lymph node metastasis. Due to its rarity, multiple RH might be erroneously interpreted as angiosarcoma with metastasis by those who were not familiar with this condition, or conduce to aggressive postoperative treatment. Therefore, thoroughly microscopical inspection and a long-term follow-up are helpful for surgeons and pathologists to obtain an accurate diagnosis and avoid clinical over-treatment.

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“…However the dermoscopic criteria of RF and other endotheliomas require further investigation and dermoscopic findings should be always be integrated with clinical information, patient age and patient history (5). Skin biopsy, therefore is at present the only diagnostic method available for an appropriate diagnosis of RH (8,9). RH should be considered a low grade angiosarcoma with high incidence of recurrence, consequently in cases where it is possible, a wide surgical excision with histopathologically proven tumor-free margins is the optimal choice (10).…”

Section: Discussionmentioning

confidence: 99%

Retiform hemangioendothelioma of the lower limbs: a case-based review

Zarian¹

2015

cderm

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SummaryRetiform hemangioendothelioma is a rare entity included in the spectrum of vascular tumors. It is considered an uncommon vascular neoplasm of intermediate or borderline malignancy (between entirely benign hemangiomas and highly malignant angiosarcomas). Retiform hemangioendothelioma is clinically characterized by exophytic nodules and plaques in the dermal or subcutaneous compartments, which grows slowly involving more often lower limbs, upper limbs and trunk. Histologically, it shows a typical vascular pattern characterized by microscopic feature of arborizing, elongated, thin-walled cavernous blood vessels dissecting the dermal collagen. In this article, we report a case of retiform hemangioendothelioma in a 86-year-old male and review the literature concerning this rare entity.

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Retiform hemangioendothelioma with lymph node metastasis: A rare entity

Cited by 35 publications

References 0 publications

Two Canine Malignant Vascular Tumours with Features of Human Retiform Haemangioendothelioma

Two Canine Malignant Vascular Tumours with Features of Human Retiform Haemangioendothelioma

Unusual multiple cutaneous retiform hemangioendothelioma on forearm and neck misdiagnosed as angiosarcoma with metastasis

Retiform hemangioendothelioma of the lower limbs: a case-based review

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