Reticuloendothelial System Activity and Organ Failure in Patients With Multiple Injuries

Pape, Hans-Christian; Remmers, D.; Grotz, M.; Kotzerke, Jörg; Gliński, S; Griensven, Martijn van; Dahlweid, Michael; Sznidar, Susanne; Tscherne, H.

doi:10.1001/archsurg.134.4.421

Cited by 50 publications

(18 citation statements)

References 37 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These effects are potentiated by interleukin-6 (IL-6) concerning recruitment, phagocytosis, and superoxide anion production [48,49]. Similar disturbances are detected in the tissue counterpart of the PMN the reticuloendothelial system [50].…”

Section: Ischemia/reperfusionmentioning

confidence: 87%

Immune Reactions after Trauma

2003

Self Cite

View full text Add to dashboard Cite

Activation of the immune system for wound healing following accidental trauma is a well-studied phenomenon. The reaction comprises both the cellular and humoral systems. The various steps in the reaction are all temporally defined and influence each other. The main cells involved are polymorphonuclear granulocytes (PMN), monocytes, and lymphocytes. They interact and adhere to the endothelium via adhesion molecules such as L-selectin and ICAM-1. The humoral mediators discussed in this review are tumor necrosis factor-␣ (TNF-␣) and its receptors, interleukin-1␤ (IL-1␤), IL-6, IL-10 and interferon-␥ (IFN-␥). The kinetics of the cells appearing and of the cytokines are discussed. The actions of these players are reviewed along with the most recent literature. Furthermore, we attempt to elucidate causal relationships. The immune system can be hyper-or hypoactive. Both exaggerated pro-and antiinflammatory reactions may have the same endpoint: multiple organ dysfunction syndrome (MODS). This knowledge should be used to meticulously monitor the patient's immunologic status. Depending on the state, hyper-or hypoinflammatory, the treatment should comprise anti-inflammatory and immune-restoring properties, respectively. What is decisive to survival is timely, adequate management based on the individual patient's status.

show abstract

Section: Ischemia/reperfusionmentioning

confidence: 87%

Immune Reactions after Trauma

2003

Self Cite

View full text Add to dashboard Cite

show abstract

“…In studies on the intestinal permeability defects in patients with MOF and combined hyperactivation of the immune system, the importance of the gut-liver axis was demonstrated [47,55]. In addition, certain injury profiles were identified that are especially prone to develop such complications (borderline patient) [43].…”

Section: Effects Of Clinical and Experimental Research On In-hospitalmentioning

confidence: 99%

Trauma Care in Germany: An Inclusive System

Sturm

Pape²,

Dienstknecht³

2013

Clinical Orthopaedics &Amp; Related Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Bei den überlebenden MOV-Patienten normalisierte sich die Leberfunktion noch während des stationären Aufenthalts [26,29]. Zum Zeitpunkt der Nachuntersuchung zeigte keiner dieser Patienten Residuen des stattgehabten Leberversagens, dies gilt sowohl für die initial suppremierte RES-Funktion als auch für die exkretorische Funktion (Bilirubin) und die Lebersyntheseleistung (Blutgerinnung).…”

Section: Bewegungseinschränkung >30% Des Gesamtbewegungsumfangs -Insgunclassified