Reticuloendothelial Blockade Produced by Antilymphocyte Serum

Sheagren, John N.; Edelin, JosephB.; Barth, RolfF.; Malmgren, Richard A.

doi:10.1016/s0140-6736(69)90057-9

Cited by 31 publications

(7 citation statements)

References 8 publications

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“…Comparable findings have been reported for the mouse by Sheagren et al [1969Sheagren et al [ , 1970Sheagren et al [ , 1971 who followed the clearance of colloidal carbon and microaggregated albumin in mice.…”

Section: Introductionsupporting

confidence: 74%

Effects of Heterologous Antiserum Ig on Function of the Reticuloendothelial System

Artis¹,

Artis²,

Blazkovec³

1973

Int Arch Allergy Immunol

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The effects of heterologous antiserum Ig on clearance and organ localization of SRBC-⁵¹Cr were studied in the guinea pig. Treatment with ALS or ATS did not suppress vascular clearance of SRBC-⁵¹Cr, whereas AMS and APES treatments significantly suppressed RES function. SRBC-⁵¹Cr localization within the liver was likewise shown to be significantly reduced in animals treated with AMS or APES suggesting impairment of the Kupffer cell function; only treatment with APES resulted in significantly lower levels of radioactivity within the lung when compared with other means of treatment.

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Section: Introductionsupporting

confidence: 74%

Effects of Heterologous Antiserum Ig on Function of the Reticuloendothelial System

Artis¹,

Artis²,

Blazkovec³

1973

Int Arch Allergy Immunol

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“…Both the circulating lymphocytes and the RES may be affected by treatment with ALS or cortisol, and numerous workers have demonstrated both stimulating and depressive effects of ALS and cortisol on the RES (CrabbC 1956, Snell 1960, Grogan 1968, Sheagren et al 1970 causes of the increased number of circulating decaying lymphocytes after such treatments. On the other hand, the exponential clearing of decaying cells from blood after the initial increase strongly suggests an optimal working RES in the greater part of the observation period.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Studies on the Decay of Lymphocytes in the Blood of the Mouse

Claësson

Olsson

1971

Scandinavian Journal of Haematology

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The number of decaying lymphocytes in the peripheral blood of the mouse was determined by means of the dye exclusion test. Under normal conditions the lymphocyte decay was very constant (1.1%). Treatment with pertussis vaccine, anti‐lymphocyte serum, and hydrocortisone either alone or in combination greatly influenced the number of decaying blood lymphocytes. Treatment with heparin markedly increased the number of circulating non‐viable lymphocytes, probably due to inhibition of the reticuloendothelial macrophage system. Methods for determination of the average period a decaying lymphocyte stays in blood were elaborated and used under normal and experimental conditions.

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“…1) and since its anti-RBC activity may have promoted phagocytosis of RBC by fixed macrophages of the livers and spleens of ATS-treated mice, functional changes in these littoral phagocytes seemed possible (24). During natural mousepox, infection of the liver and spleen follows uptake of virus from the blood by these macrophages (12).…”

Section: Effects Of a Ts On Organ Weight And Histopathology--organs mentioning

confidence: 99%

Mechanisms of Recovery From a Generalized Viral Infection: Mousepox

Blanden

1970

The Journal of Experimental Medicine

159

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The response of a host animal to primary viral infection is complex, and the factors essential for recovery from the infection are difficult to define. Immune responses, both cell-mediated and hulnoral, interferon production, pyrexia, and local changes in acidity and oxygen tension in infected tissues have all been ascribed possible roles in recovery (1). The importance of any single mechanism probably varies in diseases of different pathogenesis or at particular times during the course of infection, and there will sometimes be interaction and synergism between individual factors.Since neutralizing antibodies and interferon have well documented modes of antiviral activity, they could logically be assigned rather more importance than cell-mediated immunity, which has no clearly demonstrated antiviral mechanism. However, an increasing body of evidence derived from the study of human infants with primary immunological deficiency diseases points to a very important, perhaps even essential role for a thymus-dependent, cellmediated immune response in recovery from vaccinia virus infection (2). Experimental evidence concerning this area of host-virus relations is meager, but recently Hirsch et al. (3) showed that heterologous anti-thymocyte serum (ATS) 1 caused significantly increased mortality and morbidity from intravenous vaccinia infection in mice. They postulated that this was due to suppression of cell-mediated immunity; however no direct evidence was produced to show that the cell-mediated immune response to vaccinia virus was suppressed by ATS. This was assumed on the basis of an immunosuppressive potency test usiag lymphocytic choriomeningitis virus (4).Previously, Allison and Friedman (5, 6) had produced sound evidence that the regression of primary tumours caused by fibroma virus in rabbits was dependent upon cell-mediated immunity. However, this and other work coni Abbreviations use~ in this paper: AMS, rabbit anti-mouse macrophage serum; ATS, rabbit anti-mouse thymocyte serum; MEM, minimal essential medium; NRS, normal rabbit serum; PBS, phosphate-buffered saline; PFU, virus plaque-forming units; RBC, red blood cells WBC, white blood cells.

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Reticuloendothelial Blockade Produced by Antilymphocyte Serum

Cited by 31 publications

References 8 publications

Effects of Heterologous Antiserum Ig on Function of the Reticuloendothelial System

Effects of Heterologous Antiserum Ig on Function of the Reticuloendothelial System

Quantitative Studies on the Decay of Lymphocytes in the Blood of the Mouse

Mechanisms of Recovery From a Generalized Viral Infection: Mousepox

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