Reticulocytosis in nonanemic dogs: increasing prevalence and potential etiologies

Abstract

Prevalence of RAA has increased in recent years in our canine population. More ubiquitous use of anti-inflammatory medications and nutraceuticals, associated with increased diagnosis of osteoarthritis should be considered as contributing factors.

Reticulocytosis in non‐anaemic cats and dogs

“…non‐steroidal anti‐inflammatory drugs (NSAIDs), glucocorticoids] were identified (Pattullo et al . ). NSAIDs can induce gastrointestinal bleeding (Vollmar , Monteiro‐Steagall et al .…”

“…While factors contributing to RWA in dogs were discussed in recent studies (Pattullo et al . ), there is little information available for cats. Thus, the aim of our retrospective multicentre study was to characterise the phenomenon of RWA in cats and dogs.…”

Persistent reticulocytosis in a case of poodle macrocytosis

“…None of these risk factors were identified in this case; however, this syndrome was only recently identified, and the complete list of underlying etiologies has not yet been established. It should be noted that Pattullo et al found macrocytosis to be rare in a population of dogs with reticulocytosis in the absence of anemia …”

“…Recently, reticulocytosis in the absence of anemia was reported to be increasing in dogs and postulated to be due to chronic erythrocytic destruction, or loss . Potential causes included dietary supplementation with polyunsaturated fatty acids and zinc, administration of medications such as nonsteroidal anti‐inflammatories, glucosamine, and corticosteroids, and high‐intensity exercise.…”

“…A paraneoplastic syndrome was also unlikely due to the prolonged time, the nonprogressive nature of the hematologic abnormalities, the absence of detectable neoplasia on thoracic and abdominal imaging, and that no clinical signs were seen until euthanasia (998 days after presentation), at which time severe gastroenteritis of unknown etiology was present. A validated canine assay was not available to assess erythropoietin levels in this poodle.Recently, reticulocytosis in the absence of anemia was reported to be increasing in dogs and postulated to be due to chronic erythrocytic destruction, or loss 12. Potential causes included dietary supplementation with polyunsaturated fatty acids and zinc, administration of medications such as nonsteroidal anti-inflammatories, glucosamine, and corticosteroids, and high-intensity exercise.…”