Reticulocyte hemoglobin content

Ogawa, Chie; Tsuchiya, Ken; Maeda, Kunimi

doi:10.1016/j.cca.2020.01.032

Cited by 34 publications

(39 citation statements)

References 56 publications

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“…In CKD, this process is disrupted because the production of erythropoietin in the kidneys is decreased due to chronic inflammation. 25 Chronic inflammation in CKD causes an increase in serum ferritin as an acute phase protein. The increase in ferritin levels in these conditions reflects an increase in total body iron stores, but these stores are sequestered and cannot meet the paradoxical need for hematopoiesis, where this process will contribute to the process of anemia in inflammatory conditions.…”

Section: Resultsmentioning

confidence: 99%

Correlation between Hemoglobin Reticulocytes and Ferritin in Chronic Kidney Disease Patients Undergoing Hemodialysis at PKU Bantul

Shalahuddin

Rosita

2021

J. Berk. Ked

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As many as 7 – 12% of the world's population has chronic kidney disease (CKD). CKD patients can experience various complications, one of which is anemia. Anemia can cause a variety of cardiovascular complications in CKD patients. Enforcement of the diagnosis of anemia and its type is carried out by laboratory examination, among others by examination of reticulocytes-hemoglobin (ret-he) and iron status such as serum ferritin. Examination of these parameters can help in planning the right treatment for CKD patients who have anemia. The purpose of this study was to determine the relationship of Ret-he with ferritin levels in CKD patients undergoing hemodialysis at PKU Bantul Hospital. This study used cross-sectional method. The data source used was secondary data obtained from medical records and the Indonesian Renal Registry (IRR). Sampling research used consecutive sampling method. The analysis used univariate analysis which was frequency distribution table, and bivariate analysis. Univariate analysis obtained that average levels of ret-he from 50 subjects was 28.87 ± 3.75 pg and median serum ferritin levels were 118,1 (9,76 – 1615) mL. Bivariate analysis with pearson correlation test found a significant correlation between serum ret-he and ferritin levels (r = 0.498, p = 0.000).There was a significant correlation between he-ret levels and serum ferritin levels Keywords: chronic kidney disease, anemia, reticulocytes-hemoglobin, serum ferritin.

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Section: Resultsmentioning

confidence: 99%

Correlation between Hemoglobin Reticulocytes and Ferritin in Chronic Kidney Disease Patients Undergoing Hemodialysis at PKU Bantul

Shalahuddin

Rosita

2021

J. Berk. Ked

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“…Still, a randomized control trial including a large population is needed to observe the true benefits of those nutrients’ combination on COVID-19 patients. Supplementation can be applied for adults if their dietary components cannot meet the Recommended Dietary Allowance ( Table 4 ) [ 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 ].…”

Section: Methodsmentioning

confidence: 99%

Prospects of nutritional interventions in the care of COVID-19 patients

Alam¹,

Bhuiyan²,

Emon³

et al. 2021

Heliyon

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The novel coronavirus disease 2019 (COVID-19) has unfolded an unprecedented worldwide public health emergency with disastrous economic consequences. Around 96 million coronavirus cases have already been identified with over half a million deaths. Despite numerous efforts by the government as well as international organizations, these numbers are still increasing with a surprising rate. Although urgent and absolutely necessary, a reliable therapeutic or vaccine is still elusive and this status quo may remain for an uncertain period of time. Taken that into account, boosting up adaptive immunity through nutritional interventions may help subside this epidemic and save many lives. This review focuses on the nexus between a balanced diet and adaptive immunity, particularly, how a poor diet may lead to compromised immunity resulting in susceptibility to viral infections. Additionally, we discuss how nutrients (vitamins, minerals, trace elements) can be used as a tool to modulate immune response and thus impede viral infections. The study also summarizes nutritional recommendations to combat COVID-19 in different countries and territories as well as dietary sources of those key nutrients. Moreover, different nutritional intervention strategies based on different age groups, physiological and medical conditions were also included, and the challenges of nutritional interventions towards the care of COVID-19 patients are also discussed. Since the availability of a drug or vaccine is still uncertain, a balanced diet or nutrient therapy can be used as a robust strategy to combat COVID-19. Thus, we hope this review may help to make an informed decision with regard to diet choice both at individual level as well as clinical settings.

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“…Therefore, CHr is the ideal parameter to be considered for real-time Hb synthesis. Reticulocyte hemoglobin content is affected only by the amount of iron unless there are hematopoietic disorders (10). Determination of iron status is possible with RET-He measurement.…”

Section: Introductionmentioning

confidence: 99%

“…Again, because it is an acute phase reactant, its normal condition does not exclude IDA; the underlying etiology must be defined and regulated [9] . In contrast to all these conditions, iron overload reduces the efficiency of iron utilization and induces oxidative stress formation [10] . In addition to these, free erythrocyte zinc protoporphyrin (ER-ZPP), soluble transferrin receptor (sTfR), and reticulocyte hemoglobin content (CHr or Ret-He) are among the reliable laboratory test parameters used to describe IDA.…”

Section: Introductionmentioning

confidence: 99%

“…The values obtained reflect the reticulocyte hemoglobin content [20] . Reticulocyte hemoglobin content is more effective in diagnosing iron deficiency, determining early iron deficiency anemia, differentiation of beta-thalassemia feature, and more effective than the other parameters involved in iron metabolism [10] [12] . CHr is a less variable parameter that performs better than ferritin in response to intravenous (IV) iron therapy, providing better diagnostic accuracy for iron [15] [16] .…”

Section: Introductionmentioning

confidence: 99%

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The effect of reticulocyte hemoglobin content on the diagnosis of iron deficiency anemia: A meta-analysis study

Kılıç¹,

Özpınar²,

Serteser³

et al. 2022

J Med Biochemistry

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Background: Iron deficiency anemia (IDA) is the most common type of anemia worldwide and has many adverse effects on life quality. This meta-analysis study aims to show that reticulocyte hemoglobin content (CHr) is more effective than routinely used parameters in the diagnosis of IDA. Methods: Comprehensive and systematic research was done using international databases including PubMed, Web of Science, Cochrane Library, Science Direct, and Google Scholar, which contain all articles published on IDA until December 29, 2020. Seventeen articles were included in the meta-analysis. Results: The analyses found the Cohen's deffect size (Standardized Mean Difference) values of the parameters. Accordingly, CHr is 2.84 (95% CI 2.36 to 3.31), mean corpus volume (MCV) is 2.46 (95% CI 1.97 to 2.95), ferritin is 2.37 (95% CI 1.63 to 3.11), and transferrin saturation (TSAT) is 3.76 (95% CI 2.14 to 5.38). To diagnose IDA, the sensitivity value of the CHr concentration was found as 83.5% (95% CI 76.1 to 89.8), specificity value to be 91.8% (95% CI 85.5 to 96.4), and mean cut-off value as 28.2 pg. Conclusions: The results of our study reveal the findings that CHr is a better biomarker than MCV and ferritin used in determining IDA, and its efficacy is lower than TSAT. It is very important to use it routinely for the pre-diagnosis of IDA, which is very important for public health. The groups in the study are heterogeneous but contain bias. Therefore, meta-analyses of studies with less heterogeneity of CHr are needed.

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Reticulocyte hemoglobin content

Cited by 34 publications

References 56 publications

Correlation between Hemoglobin Reticulocytes and Ferritin in Chronic Kidney Disease Patients Undergoing Hemodialysis at PKU Bantul

Correlation between Hemoglobin Reticulocytes and Ferritin in Chronic Kidney Disease Patients Undergoing Hemodialysis at PKU Bantul

Prospects of nutritional interventions in the care of COVID-19 patients

The effect of reticulocyte hemoglobin content on the diagnosis of iron deficiency anemia: A meta-analysis study

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