Reticulo-Endotheliosis of Children: Treatment with Roentgen Rays

Childs, Donald S.; Kennedy, Roger L. J.

doi:10.1148/57.5.653

Cited by 30 publications

(6 citation statements)

References 3 publications

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“…Radiation therapy, which is beneficial with the osseous lesions of HSCD (as it actually was in our patient) was reported as effective also in some cases of cerebral HX [4,25]. Metho trexate treatment was successful in Newton and Anderson's [21] case, while cortisone and y-globulin therapy were useful in the cases of Letterer-Siwe's disease reported by Duperral et al [9] and by LeCat and Crupper [15].…”

Section: Discussionsupporting

confidence: 61%

Histiocytosis ‘X’ of the Central Nervous System

Iraci¹,

Chieco‐Bianchi²,

Giordano³

et al. 1979

Pediatr Neurosurg

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The case is presented of a child with early manifestations of Hand-Schüller-Christian disease limited to exophthalmos, and rapid final progression towards a clinical picture dominated by intracranial hypertension and cerebeliar involvement, caused by massive histiocytic infiltration of the cerebellum, combined with discrete subdural deposits of xanthomatous tissue and minor deposits in other parts of the central nervous system and other organs.

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Section: Discussionsupporting

confidence: 61%

Histiocytosis ‘X’ of the Central Nervous System

Iraci¹,

Chieco‐Bianchi²,

Giordano³

et al. 1979

Pediatr Neurosurg

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“…It is used as a single treatment option for either bony lesions or other organ involvement but also in a multimodal approach in combination with chemotherapy (CTX), surgery or steroids [6,13-16]. The mechanism of actions induced by ionizing radiation target cells remains unclear [7,17-21].…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy in langerhans cell histiocytosis - a rare indication in a rare disease

et al. 2013

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IntroductionLangerhans Cell Histiocytosis (LCH) represents a rare benign disorder, previously designated as “Histiocytosis X”, “Type II Histiocytosis” or “Langerhans Cell Granulomatosis”. Clinical presentation includes osteolysis, ulcerations of skin and soft tissues but also involvement of the CNS is described.Because treatment concepts are not well defined the German Cooperative Group on Radiotherapy for Benign Diseases performed a retrospective analysis.Methods and materialEight closely cooperating centres collected patients’ data of the past 45 years. As study endpoints disease free survival, recurrent disease, death and therapy related side effects were defined.ResultsA total of 80 patients with histologically proven LCH were irradiated within the past 45 years. According to the LCH classification of Greenberger et al. 37 patients had stage Ia, 21 patients stage Ib, 13 patients stage II and 9 patients stage IIIb and the median age was 29 years. The median Follow up was 54 months (range 9–134 months). A total of 39 patients had a surgical intervention and 23 patients a chemotherapy regimen.Radiation treatment was carried out with a median total dose of 15 Gy (range 3–50.4 Gy). The median single fraction was 2 Gy (range 1.8-3 Gy).Overall, 77% patients achieved a complete remission and 12.5% achieved a partial remission. The long-term control rate reached 80%. Within an actuarial overall 5-year survival of 90% no radiogenic side and late effects ≥EORTC/RTOG II° were observed.ConclusionIn the present study a large collective of irradiated patients was analysed. Radiotherapy (RT) is a very effective and safe treatment option and even low RT doses show sufficient local control.

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“…For several decades, radiotherapy (RT) has been reported to be effective even at very low doses for osseous manifestations of LCH, either as a single treatment, or in combination with other modalities like chemotherapy (CT), surgery or steroids [10,22,27]. The target cells and mechanisms of ionizing radiation actions remain unclear [26,33,36,37,45]; a high sensitivity of Langerhans cells to RT and an RT-induced suppression of inflammatory processes have been discussed [21].…”

Section: Introductionmentioning

confidence: 99%